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Reza Ramezan

Publications and source records attributed to Reza Ramezan.

3 recordsLinked to original sources

Fast and Scalable Inference for Spatial Extreme Value Models

The generalized extreme value (GEV) distribution is a popular model for analyzing and forecasting extreme weather data. To increase prediction accuracy, spatial information is often pooled via a latent Gaussian process (GP) on the GEV parameters. Inference for GEV-GP models is typically carried out using Markov chain Monte Carlo (MCMC) methods, or using approximate inference methods such as the integrated nested Laplace approximation (INLA). However, MCMC becomes prohibitively slow as the number of spatial locations increases, whereas INLA is only applicable in practice to a limited subset of GEV-GP models. In this paper, we revisit the original Laplace approximation for fitting spatial GEV models. In combination with a popular sparsity-inducing spatial covariance approximation technique, we show through simulations that our approach accurately estimates the Bayesian predictive distribution of extreme weather events, is scalable to several thousand spatial locations, and is several orders of magnitude faster than MCMC. A case study in forecasting extreme snowfall across Canada is presented.

stat.ME

Functional Connectivity: Continuous-Time Latent Factor Models for Neural Spike Trains

Modelling the dynamics of interactions in a neuronal ensemble is an important problem in functional connectivity research. One popular framework is latent factor models (LFMs), which have achieved notable success in decoding neuronal population dynamics. However, most LFMs are specified in discrete time, where the choice of bin size significantly impacts inference results. In this work, we present what is, to the best of our knowledge, the first continuous-time multivariate spike train LFM for studying neuronal interactions and functional connectivity. We present an efficient parameter inference algorithm for our biologically justifiable model which (1) scales linearly in the number of simultaneously recorded neurons and (2) bypasses time binning and related issues. Simulation studies show that parameter estimation using the proposed model is highly accurate. Applying our LFM to experimental data from a classical conditioning study on the prefrontal cortex in rats, we found that coordinated neuronal activities are affected by (1) the onset of the cue for reward delivery, and (2) the sub-region within the frontal cortex (OFC/mPFC). These findings shed new light on our understanding of cue and outcome value encoding.

stat.ME

A Multivariate Point Process Model for Simultaneously Recorded Neural Spike Trains

The current state-of-the-art in neurophysiological data collection allows for simultaneous recording of tens to hundreds of neurons, for which point processes are an appropriate statistical modelling framework. However, existing point process models lack multivariate generalizations which are both flexible and computationally tractable. This paper introduces a multivariate generalization of the Skellam process with resetting (SPR), a point process tailored to model individual neural spike trains. The multivariate SPR (MSPR) is biologically justified as it mimics the process of neural integration. Its flexible dependence structure and a fast parameter estimation method make it well-suited for the analysis of simultaneously recorded spike trains from multiple neurons. The strengths and weaknesses of the MSPR are demonstrated through simulation and analysis of experimental data.

stat.ME