arXiv subjects

Riasat Azim

Publications and source records attributed to Riasat Azim.

3 recordsLinked to original sources

arXiv2026

SpatialMAGIC: A Hybrid Framework Integrating Graph Diffusion and Spatial Attention for Spatial Transcriptomics Imputation

Spatial transcriptomics (ST) enables mapping gene expression with spatial context but is severely affected by high sparsity and technical noise, which conceals true biological signals and hinders downstream analyses. To address these challenges, SpatialMagic was proposed, which is a hybrid imputation model combining MAGIC-based graph diffusion with transformer-based spatial self-attention. The long-range dependencies in the gene expression are captured by graph diffusion, and local neighborhood structure is captured by spatial attention models, which allow for recovering the missing expression values, retaining spatial consistency. Across multiple platforms, SpatialMagic consistently outperforms existing baselines, including MAGIC and attention-based models, achieving peak Adjusted Rand Index (ARI) scores in clustering accuracy of 0.3301 on high-resolution Stereo-Seq data, 0.3074 on Slide-Seq, and 0.4216 on the Sci-Space dataset. Beyond quantitative improvements, SpatialMagic substantially enhances downstream biological analyses by improving the detection of both up- and down-regulated genes while maintaining regulatory consistency across datasets. The pathway enrichment analysis of the recovered genes indicates that they are involved in consistent processes across key metabolic, transport, and neural signaling pathways, suggesting that the framework improves data quality while preserving biological interpretability. Overall, SpatialMagic's hybrid diffusion attention strategy and refinement module outperform state-of-the-art baselines on quantitative metrics and provide a better understanding of the imputed data by preserving tissue architecture and uncovering biologically relevant genes. The source code and datasets are provided in the following link: https://github.com/sayeemzzaman/SpatialMAGIC

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arXiv2026

An Energy-Efficient Smart Bus Transport Management System with Blind-Spot Collision Detection Ability

Public bus transport systems in developing countries often suffer from a lack of real-time location updates and for users, making commuting inconvenient and unreliable for passengers. Furthermore, stopping at undesired locations rather than designated bus stops creates safety risks and contributes to roadblocks, often causing traffic congestion. Additionally, issues such as blind spots, along with a lack of following traffic laws, increase the chances of accidents. In this work, we address these challenges by proposing a smart public bus system along with intelligent bus stops that enhance safety, efficiency, and sustainability. Our approach includes a deep learning-based blind-spot warning system to help drivers avoid accidents with automated bus-stop detection to accurately identify bus stops, improving transit efficiency. We also introduce IoT-based solar-powered smart bus stops that show real-time passenger counts, along with an RFID-based card system to track where passengers board and exit. A smart door system ensures safer and more organised boarding, while real-time bus tracking keeps passengers informed. To connect all these features, we use an HTTP-based server for seamless communication between the interconnected network systems. Our proposed system demonstrated approximately 99% efficiency in real-time blind spot detection while stopping precisely at the bus stops. Furthermore, the server showed real-time location updates both to the users and at the bus stops, enhancing commuting efficiency. The proposed energy-efficient bus stop demonstrated 12.71kWh energy saving, promoting sustainable architecture. Full implementation and source code are available at: https://github.com/sadman-adib/MoveMe-IoT

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arXiv2025

GBDTSVM: Combined Support Vector Machine and Gradient Boosting Decision Tree Framework for efficient snoRNA-disease association prediction

Small nucleolar RNAs (snoRNAs) are increasingly recognized for their critical role in the pathogenesis and characterization of various human diseases. Consequently, the precise identification of snoRNA-disease associations (SDAs) is essential for the progression of diseases and the advancement of treatment strategies. However, conventional biological experimental approaches are costly, time-consuming, and resource-intensive; therefore, machine learning-based computational methods offer a promising solution to mitigate these limitations. This paper proposes a model called 'GBDTSVM', representing a novel and efficient machine learning approach for predicting snoRNA-disease associations by leveraging a Gradient Boosting Decision Tree (GBDT) and Support Vector Machine (SVM). 'GBDTSVM' effectively extracts integrated snoRNA-disease feature representations utilizing GBDT and SVM is subsequently utilized to classify and identify potential associations. Furthermore, the method enhances the accuracy of these predictions by incorporating Gaussian kernel profile similarity for both snoRNAs and diseases. Experimental evaluation of the GBDTSVM model demonstrated superior performance compared to state-of-the-art methods in the field, achieving an area under the receiver operating characteristic (AUROC) of 0.96 and an area under the precision-recall curve (AUPRC) of 0.95 on MDRF dataset. Moreover, our model shows superior performance on two more datasets named LSGT and PsnoD. Additionally, a case study on the predicted snoRNA-disease associations verified the top 10 predicted snoRNAs across nine prevalent diseases, further validating the efficacy of the GBDTSVM approach. These results underscore the model's potential as a robust tool for advancing snoRNA-related disease research. Source codes and datasets our proposed framework can be obtained from: https://github.com/mariamuna04/gbdtsvm

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