Optimal designs for incomplete stepped wedge trials
Background: Stepped wedge trials are longitudinal randomised evaluations, usually cluster-randomised, in which the experimental intervention is introduced in a staggered fashion. Incomplete stepped wedge designs focus the effort of data collection on particular periods in particular sequences. Methods: We suppose there is a cost for every period in every cluster where we collect data, and that there are a fixed number of individuals, m, with data available in each period in each cluster. If we are willing to pay the cost of data collection in that cluster-period then we collect the data on all m individuals, and if we are not willing to pay the cost then we collect no data in that cluster-period. We consider the problem of designing a trial to minimise the total number of cluster-periods of data collection needed to achieve given precision for the treatment effect estimator, or equivalently, to maximise precision for a given number of cluster-periods of data collection. Results: We present the solution for two-period trials, which has two distinct forms, depending on the correlation between two cluster-period means from the same cluster in different periods. We also present a conjecture on the form of the solution for multi-period trials, informed by results from a greedy search of the design space. Conclusions: A real-life stepped wedge design problem will involve trading off the costs of various design elements subject also to constraints on the scale of data collection. Nevertheless, the solutions to the problem considered here add significantly to our understanding of the optimal design of incomplete stepped wedge trials.