arXiv subjects

Richard Middleton

Publications and source records attributed to Richard Middleton.

4 recordsLinked to original sources

arXiv2020

Scalability in nonlinear network systems affected by delays and disturbances

This paper is concerned with the study of scalability in nonlinear heterogeneous networks affected by communication delays and disturbances. After formalizing the notion of scalability, we give two sufficient conditions to assess this property. Our results can be used to study leader-follower and leaderless networks and also allow to consider the case when the desired configuration of the system changes over time. We show how our conditions can be turned into design guidelines to guarantee scalability and illustrate their effectiveness via numerical examples.

eess.SY↗

arXiv2020

An analytical bound on the fleet size in vehicle routing problems: a dynamic programming approach

We present an analytical upper bound on the number of required vehicles for vehicle routing problems with split deliveries and any number of capacitated depots. We show that a fleet size greater than the proposed bound is not achievable based on a set of common assumptions. This property of the upper bound is proved through a dynamic programming approach. We also discuss the validity of the bound for a wide variety of routing problems with or without split deliveries.

math.OC↗

arXiv2014

Uncertainty quantification for CO2 sequestration and enhanced oil recovery

This study develops a statistical method to perform uncertainty quantification for understanding CO2 storage potential within an enhanced oil recovery (EOR) environment at the Farnsworth Unit of the Anadarko Basin in northern Texas. A set of geostatistical-based Monte Carlo simulations of CO2-oil-water flow and reactive transport in the Morrow formation are conducted for global sensitivity and statistical analysis of the major uncertainty metrics: net CO2 injection, cumulative oil production, cumulative gas (CH4) production, and net water injection. A global sensitivity and response surface analysis indicates that reservoir permeability, porosity, and thickness are the major intrinsic reservoir parameters that control net CO2 injection/storage and oil/gas recovery rates. The well spacing and the initial water saturation also have large impact on the oil/gas recovery rates. Further, this study has revealed key insights into the potential behavior and the operational parameters of CO2 sequestration at CO2-EOR sites, including the impact of reservoir characterization uncertainty; understanding this uncertainty is critical in terms of economic decision making and the cost-effectiveness of CO2 storage through EOR.

physics.geo-ph↗

arXiv2008

Optimal metabolic pathway activation

This paper deals with temporal enzyme distribution in the activation of biochemical pathways. Pathway activation arises when production of a certain biomolecule is required due to changing environmental conditions. Under the premise that biological systems have been optimized through evolutionary processes, a biologically meaningful optimal control problem is posed. In this setup, the enzyme concentrations are assumed to be time dependent and constrained by a limited overall enzyme production capacity, while the optimization criterion accounts for both time and resource usage. Using geometric arguments we establish the bang-bang nature of the solution and reveal that each reaction must be sequentially activated in the same order as they appear in the pathway. The results hold for a broad range of enzyme dynamics which includes, but is not limited to, Mass Action, Michaelis-Menten and Hill Equation kinetics.

q-bio.QM↗