Energy Conversion, Fluctuation Suppression, and Information Transfer in the Thermodynamic Performance of Kinesin
Kinesin is a molecular motor that transports intracellular cargoes along microtubules. Recent studies have quantified kinesin performance using various efficiencies within the framework of stochastic thermodynamics; however, quantitative comparisons remain difficult because different models and assumptions have been employed. As a result, it remains unclear which aspect of kinesin performance, if any, is thermodynamically optimized. Here, we systematically compare multiple thermodynamic efficiencies within a single kinesin-cargo model. To this end, we construct a thermodynamically consistent two-state kinesin-cargo model that retains both the discrete stepping of kinesin and its coupling to the cargo. Assuming a separation of time scales between the motor and the cargo, we derive analytical expressions for the thermodynamic efficiency, the information-thermodynamic efficiency, the thermodynamic uncertainty relation (TUR) efficiency, and the bipartite TUR efficiency, and compare them with numerical simulation results. We find that these efficiencies generally remain low, suggesting that kinesin is not optimized for maximizing the thermodynamic efficiencies considered here. Our results suggest that thermodynamic efficiencies alone may not fully characterize kinesin performance and motivate further investigation of complementary kinetic perspectives for assessing molecular motor function.