arXiv subjects

Riyang Bao

Publications and source records attributed to Riyang Bao.

11 recordsLinked to original sources

arXiv2026

From Bench-to-Bedside: A Review of Clinical Trials in Drug Discovery and Development

Clinical trials bridge basic research and clinical application, serving as essential steps in drug development. This review examines clinical trial phases (Phase I [safety assessment], Phase II [efficacy evaluation], Phase III [large-scale validation], and Phase IV [post-marketing surveillance]), highlighting the distinct characteristics and interconnections. Major challenges are identified, including ethical compliance, participant recruitment, and ensuring diversity and representativeness in trial populations, while proposing evidence-based mitigation strategies. To address these challenges, innovative technologies, such as artificial intelligence, big data analytics, and digital health tools, are transforming trial design and implementation, enhancing efficiency and data quality. Looking forward, the review explores how emerging therapies, including gene therapy and immunotherapy, are reshaping trial design requirements and emphasizes the growing importance of regulatory harmonization and global collaboration. Clinical trials remain central to advancing innovative drug development and improving patient outcomes.

cs.CY↗

arXiv2026

Staypoint Detection from Noisy Trajectory Data [Experiment Paper]

Detecting staypoints from raw trajectory data is fundamental to numerous spatial computing applications. This process transforms raw numeric sequences of geolocations into semantically meaningful locations, such as homes, workplaces, or restaurants. Despite its importance for semantic trajectory analysis, staypoint detection lacks standard benchmarks, and existing algorithms have never been systematically evaluated. This gap persists because no publicly available datasets provide both raw individual trajectories and ground-truth staypoint annotations. This benchmark paper addresses this limitation with two key contributions: (1) we introduce 16 large-scale simulated datasets capturing thousands of agents with annotated staypoints across varying trajectory noise levels, and (2) we evaluate nine staypoint detection algorithms-including both state-of-the-art and novel methods-to analyze their robustness to noise. Our evaluation reveals that existing state-of-the-art algorithms perform poorly under realistic noise conditions. Conversely, our proposed unsupervised methods yield substantial improvements, while supervised approaches drastically outperform existing baselines. While these results are very promising, these datasets and methods are only meant as starting points for future research in staypoint detection.

cs.LG↗

arXiv2026

Learning-Based Automated Adversarial Red-Teaming for Robustness Evaluation of Large Language Models

Red-teaming is becoming a central part of large language model (LLM) safety evaluation, yet current practice still relies heavily on expert-written prompts or fixed benchmark suites. This creates a gap between what is easy to test and what deployed models can actually do: failures may be rare, context-sensitive, and distributed across many threat categories. We study automated red-teaming as a constrained adversarial search problem and introduce a learning-driven framework that couples category-aware attack generation with hierarchical vulnerability detection. The method starts from curated safety seeds, expands them through meta-prompt-guided and evolutionary search, and scores the resulting prompt--response pairs with lexical, semantic, and behavioral detectors. Across six threat categories on GPT-OSS-20B, the framework discovers 47 validated vulnerabilities, including 21 high-severity cases and 12 novel attack patterns. Under matched query budgets, it achieves a 3.9$\times$ higher discovery rate than manual expert red-teaming while maintaining 89\% detection accuracy and full category coverage. Ablations show that the gains do not come from more prompts alone: diversity constraints prevent template collapse, coverage constraints prevent category blind spots, and semantic detection recovers failures missed by lexical rules. These results suggest that red-teaming can be made more scalable and reproducible when treated as adaptive search rather than as a static checklist.

cs.CR↗

arXiv2026

AOI: Context-Aware Multi-Agent Operations via Dynamic Scheduling and Hierarchical Memory Compression

Cloud-native systems have made operational work both more powerful and harder to automate: incidents unfold across microservices, logs and metrics arrive faster than operators can inspect them, and recovery actions must be coordinated without losing the causal context that makes them safe. We present AOI (AI-Oriented Operations), a context-aware multi-agent framework for autonomous IT operations. AOI separates operational responsibility across an Observer, a read-only Probe, and a guarded Executor, and connects them through dynamic scheduling and a hierarchical memory system with LLM-based context compression. This design turns long-running incident response into an iterative loop of observation, evidence gathering, safe intervention, and memory update. Across AIOpsLab simulations and real-world Loghub-derived scenarios, AOI improves task success to 94.2\%, reduces mean time to resolution by 34.4\% relative to the strongest baseline, and compresses operational context by 72.4\% while preserving 92.8\% of diagnostic information. Ablations show that these gains come from the combination of agent specialization, adaptive scheduling, and memory-aware compression rather than from any single module alone. The results suggest that autonomous operations systems can move beyond alert classification toward reliable, context-preserving recovery in complex infrastructure.

cs.MA↗

arXiv2026

Jailbreaking and Mitigation of Vulnerabilities in Large Language Models

Large Language Models (LLMs) have transformed artificial intelligence by advancing natural language understanding and generation, enabling applications across fields beyond healthcare, software engineering, and conversational systems. Despite these advancements in the past few years, LLMs have shown considerable vulnerabilities, particularly to prompt injection and jailbreaking attacks. This review analyzes the state of research on these vulnerabilities and presents available defense strategies. We roughly categorize attack approaches into prompt-based, model-based, multimodal, and multilingual, covering techniques such as adversarial prompting, backdoor injections, and cross-modality exploits. We also review various defense mechanisms, including prompt filtering, transformation, alignment techniques, multi-agent defenses, and self-regulation, evaluating their strengths and shortcomings. We also discuss key metrics and benchmarks used to assess LLM safety and robustness, noting challenges like the quantification of attack success in interactive contexts and biases in existing datasets. Identifying current research gaps, we suggest future directions for resilient alignment strategies, advanced defenses against evolving attacks, automation of jailbreak detection, and consideration of ethical and societal impacts. This review emphasizes the need for continued research and cooperation within the AI community to enhance LLM security and ensure their safe deployment.

cs.CR↗

arXiv2026

Spatial-Agent: Agentic Geo-spatial Reasoning with Scientific Core Concepts

Geospatial reasoning is essential for real-world applications such as urban analytics, transportation planning, and disaster response. However, existing LLM-based agents often fail at genuine geospatial computation, relying instead on web search or pattern matching while hallucinating spatial relationships. We present Spatial-Agent, an AI agent grounded in foundational theories of spatial information science. Our approach formalizes geo-analytical question answering as a concept transformation problem, where natural-language questions are parsed into executable workflows represented as GeoFlow Graphs -- directed acyclic graphs with nodes corresponding to spatial concepts and edges representing transformations. Drawing on spatial information theory, Spatial-Agent extracts spatial concepts, assigns functional roles with principled ordering constraints, and composes transformation sequences through template-based generation. Extensive experiments on MapEval-API and MapQA benchmarks demonstrate that Spatial-Agent significantly outperforms existing baselines including ReAct and Reflexion, while producing interpretable and executable geospatial workflows.

cs.AI↗

arXiv2026

From In Silico to In Vitro: A Comprehensive Guide to Validating Bioinformatics Findings

The integration of bioinformatics predictions and experimental validation plays a pivotal role in advancing biological research, from understanding molecular mechanisms to developing therapeutic strategies. Bioinformatics tools and methods offer powerful means for predicting gene functions, protein interactions, and regulatory networks, but these predictions must be validated through experimental approaches to ensure their biological relevance. This review explores the various methods and technologies used for experimental validation, including gene expression analysis, protein-protein interaction verification, and pathway validation. We also discuss the challenges involved in translating computational predictions to experimental settings and highlight the importance of collaboration between bioinformatics and experimental research. Finally, emerging technologies, such as CRISPR gene editing, next-generation sequencing, and artificial intelligence, are shaping the future of bioinformatics validation and driving more accurate and efficient biological discoveries.

q-bio.GN↗

arXiv2025

Large Language Models and Cognitive Science: A Comprehensive Review of Similarities, Differences, and Challenges

This comprehensive review explores the intersection of Large Language Models (LLMs) and cognitive science, examining similarities and differences between LLMs and human cognitive processes. We analyze methods for evaluating LLMs cognitive abilities and discuss their potential as cognitive models. The review covers applications of LLMs in various cognitive fields, highlighting insights gained for cognitive science research. We assess cognitive biases and limitations of LLMs, along with proposed methods for improving their performance. The integration of LLMs with cognitive architectures is examined, revealing promising avenues for enhancing artificial intelligence (AI) capabilities. Key challenges and future research directions are identified, emphasizing the need for continued refinement of LLMs to better align with human cognition. This review provides a balanced perspective on the current state and future potential of LLMs in advancing our understanding of both artificial and human intelligence.

cs.AI↗

arXiv2025

From Text to Multimodality: Exploring the Evolution and Impact of Large Language Models in Medical Practice

Large Language Models (LLMs) have rapidly evolved from text-based systems to multimodal platforms, significantly impacting various sectors including healthcare. This comprehensive review explores the progression of LLMs to Multimodal Large Language Models (MLLMs) and their growing influence in medical practice. We examine the current landscape of MLLMs in healthcare, analyzing their applications across clinical decision support, medical imaging, patient engagement, and research. The review highlights the unique capabilities of MLLMs in integrating diverse data types, such as text, images, and audio, to provide more comprehensive insights into patient health. We also address the challenges facing MLLM implementation, including data limitations, technical hurdles, and ethical considerations. By identifying key research gaps, this paper aims to guide future investigations in areas such as dataset development, modality alignment methods, and the establishment of ethical guidelines. As MLLMs continue to shape the future of healthcare, understanding their potential and limitations is crucial for their responsible and effective integration into medical practice.

cs.CY↗

arXiv2025

Large Language Model Benchmarks in Medical Tasks

With the increasing application of large language models (LLMs) in the medical domain, evaluating these models' performance using benchmark datasets has become crucial. This paper presents a comprehensive survey of various benchmark datasets employed in medical LLM tasks. These datasets span multiple modalities including text, image, and multimodal benchmarks, focusing on different aspects of medical knowledge such as electronic health records (EHRs), doctor-patient dialogues, medical question-answering, and medical image captioning. The survey categorizes the datasets by modality, discussing their significance, data structure, and impact on the development of LLMs for clinical tasks such as diagnosis, report generation, and predictive decision support. Key benchmarks include MIMIC-III, MIMIC-IV, BioASQ, PubMedQA, and CheXpert, which have facilitated advancements in tasks like medical report generation, clinical summarization, and synthetic data generation. The paper summarizes the challenges and opportunities in leveraging these benchmarks for advancing multimodal medical intelligence, emphasizing the need for datasets with a greater degree of language diversity, structured omics data, and innovative approaches to synthesis. This work also provides a foundation for future research in the application of LLMs in medicine, contributing to the evolving field of medical artificial intelligence.

cs.CL↗

arXiv2025

Spatial-RAG: Spatial Retrieval Augmented Generation for Real-World Geospatial Reasoning Questions

Answering real-world geospatial questions--such as finding restaurants along a travel route or amenities near a landmark--requires reasoning over both geographic relationships and semantic user intent. However, existing large language models (LLMs) lack spatial computing capabilities and access to up-to-date, ubiquitous real-world geospatial data, while traditional geospatial systems fall short in interpreting natural language. To bridge this gap, we introduce Spatial-RAG, a Retrieval-Augmented Generation (RAG) framework designed for geospatial question answering. Spatial-RAG integrates structured spatial databases with LLMs via a hybrid spatial retriever that combines sparse spatial filtering and dense semantic matching. It formulates the answering process as a multi-objective optimization over spatial and semantic relevance, identifying Pareto-optimal candidates and dynamically selecting the best response based on user intent. Experiments across multiple tourism and map-based QA datasets show that Spatial-RAG significantly improves accuracy, precision, and ranking performance over strong baselines.

cs.IR↗