arXiv subjects

Robert Azencott

Publications and source records attributed to Robert Azencott.

22 records · Page 2Linked to original sources

arXiv2014

Markov Random Fields and Mass Spectra Discrimination

For mass spectra acquired from cancer patients by MALDI or SELDI techniques, automated discrimination between cancer types or stages has often been implemented by machine learnings. These techniques typically generate "black-box" classifiers, which are difficult to interpret biologically. We develop new and efficient signature discovery algorithms leading to interpretable signatures combining the discriminating power of explicitly selected small groups of biomarkers, identified by their m/z ratios. Our approach is based on rigorous stochastic modeling of "homogeneous" datasets of mass spectra by a versatile class of parameterized Markov Random Fields. We present detailed algorithms validated by precise theoretical results. We also outline the successful tests of our approach to generate efficient explicit signatures for six benchmark discrimination tasks, based on mass spectra acquired from colorectal cancer patients, as well as from ovarian cancer patients.

stat.ML↗

arXiv2014

Accuracy of Maximum Likelihood Parameter Estimators for Heston volatility SDE

We study approximate maximum likelihood estimators (MLEs) for the parameters of the widely used Heston stock and volatility stochastic differential equations (SDEs). We compute explicit closed form estimators maximizing the discretized log-likelihood of $N$ observations recorded at times $T,2T, \ldots, NT$. We study the asymptotic bias of these parameter estimators first for $T$ fixed and $N \to \infty$, as well as when the global observation time $S= NT \to \infty$ and $T = S/N \to 0$. We identify two explicit key functions of the parameters which control the type of asymptotic distribution of these estimators, and we analyze the dichotomy between asymptotic normality and attraction by stable like distributions with heavy tails. \\ We present two examples of model fitting for Heston SDEs, one for daily data and one for intraday data, with moderate values of $N$.

math.PR↗

arXiv2014

Modeling delay in genetic networks: From delay birth-death processes to delay stochastic differential equations

Delay is an important and ubiquitous aspect of many biochemical processes. For example, delay plays a central role in the dynamics of genetic regulatory networks as it stems from the sequential assembly of first mRNA and then protein. Genetic regulatory networks are therefore frequently modeled as stochastic birth-death processes with delay. Here we examine the relationship between delay birth-death processes and their appropriate approximating delay chemical Langevin equations. We prove that the distance between these two descriptions, as measured by expectations of functionals of the processes, converges to zero with increasing system size. Further, we prove that the delay birth-death process converges to the thermodynamic limit as system size tends to infinity. Our results hold for both fixed delay and distributed delay. Simulations demonstrate that the delay chemical Langevin approximation is accurate even at moderate system sizes. It captures dynamical features such as the spatial and temporal distributions of transition pathways in metastable systems, oscillatory behavior in negative feedback circuits, and cross-correlations between nodes in a network. Overall, these results provide a foundation for using delay stochastic differential equations to approximate the dynamics of birth-death processes with delay.

q-bio.MN↗

arXiv2013

Realtime market microstructure analysis: online Transaction Cost Analysis

Motivated by the practical challenge in monitoring the performance of a large number of algorithmic trading orders, this paper provides a methodology that leads to automatic discovery of the causes that lie behind a poor trading performance. It also gives theoretical foundations to a generic framework for real-time trading analysis. Academic literature provides different ways to formalize these algorithms and show how optimal they can be from a mean-variance, a stochastic control, an impulse control or a statistical learning viewpoint. This paper is agnostic about the way the algorithm has been built and provides a theoretical formalism to identify in real-time the market conditions that influenced its efficiency or inefficiency. For a given set of characteristics describing the market context, selected by a practitioner, we first show how a set of additional derived explanatory factors, called anomaly detectors, can be created for each market order. We then will present an online methodology to quantify how this extended set of factors, at any given time, predicts which of the orders are underperforming while calculating the predictive power of this explanatory factor set. Armed with this information, which we call influence analysis, we intend to empower the order monitoring user to take appropriate action on any affected orders by re-calibrating the trading algorithms working the order through new parameters, pausing their execution or taking over more direct trading control. Also we intend that use of this method in the post trade analysis of algorithms can be taken advantage of to automatically adjust their trading action.

q-fin.TR↗