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Robert Smits

Publications and source records attributed to Robert Smits.

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Behavior of Absorbing and Generating $p$-Robin Eigenvalues in Bounded and Exterior Domains

We establish rigorous quantitative inequalities for the first eigenvalue of the generalized $p$-Robin problem, for both the classical diffusion absorption case, where the Robin boundary parameter $\alpha$ is positive, and the superconducting generation regime ($\alpha<0$), where the boundary acts as a source. In bounded domains, we use a unified approach to derive a precise asymptotic behavior for all $p$ and all small real $\alpha$, improving existing results in various directions, including requiring weaker boundary regularity for the case of the classical 2-Robin problem, studied in the fundamental work by Ren\'e Sperb. In exterior domains, we characterize the existence of eigenvalues, establish general inequalities and asymptotics as $\alpha\to 0$ for the first eigenvalue of the exterior of a ball, and obtain some sharp geometric inequalities for convex domains in two dimensions.

math.AP

A discrete in continuous mathematical model of cardiac progenitor cells formation and growth as spheroid clusters (Cardiospheres)

We propose a discrete in continuous mathematical model describing the in vitro growth process of biophsy-derived mammalian cardiac progenitor cells growing as clusters in the form of spheres (Cardiospheres). The approach is hybrid: discrete at cellular scale and continuous at molecular level. In the present model cells are subject to the self-organizing collective dynamics mechanism and, additionally, they can proliferate and differentiate, also depending on stochastic processes. The two latter processes are triggered and regulated by chemical signals present in the environment. Numerical simulations show the structure and the development of the clustered progenitors and are in a good agreement with the results obtained from in vitro experiments.

q-bio.CB