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Roberto Herrero

Publications and source records attributed to Roberto Herrero.

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Face morphometric profiles of groups as early markers for certain diseases?

Background: Face morphometry has been shown to work as a diagnosis tool in a set of syndromes. Face similarities are usually indications of more complete genetic similarities. Purpose: To show preliminary results on the face morphometry profile of the Cuban population and to argue that it could be used to define early markers for diseases, like Alzheimer. Methods: A dataset composed of photos of 200000 men is processed. Facial landmarks are extracted by means of the DLIB library and distances between them are computed. By clustering samples with similar facial traits, groups are formed and their densities inside the population are computed. Results: The face morphometry profiles for two age cohorts are obtained, showing the population dynamics. Genes involved in facial development are shown to be related to Alzheimer's disease. Conclusions: Late multifactorial diseases develop against the genetic background of each individual, which is expressed by its face morphometry. The latter can be thus considered a risk marker.

q-bio.PE

Levy model of cancer

A small portion of a tissue defines a microstate in gene expression space. Mutations, epigenetic events or external factors cause microstate displacements which are modeled by combining small independent gene expression variations and large Levy jumps, resulting from the collective variations of a set of genes. The risk of cancer in a tissue is estimated as the microstate probability to transit from the normal to the tumor region in gene expression space. The formula coming from the contribution of large Levy jumps seems to provide a qualitatively correct description of the lifetime risk of cancer, and reveals an interesting connection between the risk and the way the tissue is protected against infections.

q-bio.PE