arXiv subjects

Roger S. Zoh

Publications and source records attributed to Roger S. Zoh.

12 recordsLinked to original sources

arXiv2026

Inferential Validity of Digital Health Measures

Digital health measures increasingly inform treatment evaluation, risk classification, clinical monitoring, and regulatory decisions. Existing validity concepts concern a measure's technical soundness, clinical meaningfulness, usability, and scalability. Inferential validity concerns how well a measure supports a scientific, clinical, or regulatory conclusion. We propose assessing inferential validity as a downstream evaluation layer that links measurement system evidence to trustworthy conclusions.

stat.OT↗

arXiv2026

Correcting Measurement Error and Zero Inflation in Functional Covariates for Scalar-on-Function Quantile Regression

Wearable devices collect time-varying biobehavioral data, offering opportunities to investigate how behaviors influence health outcomes. However, these data often contain measurement error and excess zeros (due to nonwear, sedentary behavior, or connectivity issues), each characterized by subject-specific distributions. Current statistical methods fail to address these issues simultaneously. We introduce a novel modeling framework for zero-inflated and error-prone functional data by incorporating a subject-specific time-varying validity indicator that explicitly distinguishes structural zeros from intrinsic values. We iteratively estimate the latent functional covariates and zero-inflation probabilities via maximum likelihood, using basis expansions and linear mixed models to adjust for measurement error. To assess the effects of the recovered latent covariates, we apply joint quantile regression across multiple quantile levels. Through extensive simulations, we demonstrate that our approach significantly improves estimation accuracy over methods that only address measurement error, and joint estimation yields substantial improvements compared with fitting separate quantile regressions. Applied to a childhood obesity study, our approach effectively corrects for zero inflation and measurement error in step counts, yielding results that closely align with energy expenditure and supporting their use as a proxy for physical activity.

stat.ME↗

arXiv2026

Estimating the effect of lymphovascular invasion on 2-year survival probability under endogeneity: a recursive copula-based approach

Lymphovascular invasion (LVI) is an important prognostic marker for head and neck squamous cell carcinoma (HNSC), but the true effect of LVI on survival may be distorted by endogeneity arising from unmeasured confounding. Conventional one-stage conditional models and instrument-based two-stage estimators are prone to bias under endogeneity, and sufficiently strong instruments are often unavailable in practice. To address these challenges, we propose a semiparametric recursive copula framework that jointly specifies marginal models for both LVI, treated as an endogenous exposure, and a binary 2-year survival outcome, and links them through a flexible copula to account for latent confounding and accommodate censoring without requiring strong instruments. In two simulation studies, we systematically varied sample sizes, censoring rates from 0% to 60%, and endogeneity strengths, and assessed robustness under moderate model misspecification. The proposed copula framework exhibited reduced bias and improved interval coverage compared with both one-stage and two-stage approaches while maintaining robustness to moderate misspecification. We applied the method to HNSC cases with associated clinical and microRNA data from The Cancer Genome Atlas (n = 215), and found that LVI significantly reduced 2-year survival probability by approximately 47%, with a 95% confidence interval of -0.61 to -0.29 on the probability scale. The estimated positive dependence parameter indicates that the attenuation is driven by residual dependence between unobserved components of LVI and survival. Overall, the proposed copula framework yields more credible effect estimates for survival outcomes in the absence of strong instruments, mitigating biases due to endogeneity and censoring and strengthening quantitative evidence for HNSC research.

stat.ME↗

arXiv2025

Addressing zero-inflated and mis-measured functional predictors in scalar-on-function regression model

Wearable devices are often used in clinical and epidemiological studies to monitor physical activity behavior and its influence on health outcomes. These devices are worn over multiple days to record activity patterns, such as step counts recorded at the minute level, resulting in multi-level, longitudinal, high-dimensional, or functional data. When monitoring patterns of step counts over multiple days, devices may record excess zeros during periods of sedentary behavior or non-wear times. Additionally, it has been demonstrated that the accuracy of wearable devices in monitoring true physical activity patterns depends on the intensity of the activities and wear times. While work on adjusting for biases due to measurement errors in functional data is a growing field, relatively less work has been done to study the occurrence of excess zeros along with measurement errors and their combined influence on estimation and inference in multi-level scalar-on-function regression models. We propose semi-continuous modeling approaches to adjust for biases due to zero inflation and measurement errors in scalar-on-function regression models. We provide theoretical justifications for our proposed methods and, through extensive simulations, we demonstrated their finite sample properties. Finally, the developed methods are applied to a school-based intervention study examining the association between school day physical activity with age- and sex-adjusted body mass index among elementary school-aged children.

stat.ME↗

arXiv2025

Least squares-based methods to bias adjustment in scalar-on-function regression model using a functional instrumental variable

Instrumental variables are widely used to adjust for measurement error bias when assessing associations of health outcomes with ME prone independent variables. IV approaches addressing ME in longitudinal models are well established, but few methods exist for functional regression. We develop two methods to adjust for ME bias in scalar on function linear models. We regress a scalar outcome on an ME prone functional variable using a functional IV for model identification and propose two least squares based methods to adjust for ME bias. Our methods alleviate potential computational challenges encountered when applying classical regression calibration methods for bias adjustment in high dimensional settings and adjust for potential serial correlations across time. Simulations demonstrate faster run times, lower bias, and lower AIMSE for the proposed methods when compared to existing approaches. The proposed methods were applied to investigate the association between body mass index and wearable device-based physical activity intensity among community dwelling adults living in the United States.

stat.ME↗

arXiv2025

Functional Linear Cox Regression Model with Frailty

This paper presents a functional linear Cox regression model with frailty to tackle unobserved heterogeneity in survival data with functional covariates. While traditional Cox models are common, they struggle to incorporate frailty effects that represent individual differences not captured by observed covariates. Our model combines scalar and functional covariates with a frailty term to address these unmeasured influences, creating a robust framework for high-dimensional survival analysis. We estimate parameters using functional principal component analysis and apply penalized partial likelihood for the frailty structure. A simulation study shows that our model outperforms traditional approaches in estimation accuracy and predictive capacity, especially with high frailty. We also analyze data from the National Health and Nutrition Examination Survey, highlighting significant links between physical activity and mortality in frail subpopulations. Our findings demonstrate the model's effectiveness in managing complex survival data, with potential applications in biomedical research related to unobserved heterogeneity. The method is available as an R package.

stat.ME↗

arXiv2024

Spatial function-on-function regression

We introduce a spatial function-on-function regression model to capture spatial dependencies in functional data by integrating spatial autoregressive techniques with functional principal component analysis. The proposed model addresses a critical gap in functional regression by enabling the analysis of functional responses influenced by spatially correlated functional predictors, a common scenario in fields such as environmental sciences, epidemiology, and socio-economic studies. The model employs a spatial functional principal component decomposition on the response and a classical functional principal component decomposition on the predictor, transforming the functional data into a finite-dimensional multivariate spatial autoregressive framework. This transformation allows efficient estimation and robust handling of spatial dependencies through least squares methods. In a series of extensive simulations, the proposed model consistently demonstrated superior performance in estimating both spatial autocorrelation and regression coefficient functions compared to some favorably existing traditional approaches, particularly under moderate to strong spatial effects. Application of the proposed model to Brazilian COVID-19 data further underscored its practical utility, revealing critical spatial patterns in confirmed cases and death rates that align with known geographic and social interactions. An R package provides a comprehensive implementation of the proposed estimation method, offering a user-friendly and efficient tool for researchers and practitioners to apply the methodology in real-world scenarios.

stat.ME↗

arXiv2024

Scalable regression calibration approaches to correcting measurement error in multi-level generalized functional linear regression models with heteroscedastic measurement errors

Wearable devices permit the continuous monitoring of biological processes, such as blood glucose metabolism, and behavior, such as sleep quality and physical activity. The continuous monitoring often occurs in epochs of 60 seconds over multiple days, resulting in high dimensional longitudinal curves that are best described and analyzed as functional data. From this perspective, the functional data are smooth, latent functions obtained at discrete time intervals and prone to homoscedastic white noise. However, the assumption of homoscedastic errors might not be appropriate in this setting because the devices collect the data serially. While researchers have previously addressed measurement error in scalar covariates prone to errors, less work has been done on correcting measurement error in high dimensional longitudinal curves prone to heteroscedastic errors. We present two new methods for correcting measurement error in longitudinal functional curves prone to complex measurement error structures in multi-level generalized functional linear regression models. These methods are based on two-stage scalable regression calibration. We assume that the distribution of the scalar responses and the surrogate measures prone to heteroscedastic errors both belong in the exponential family and that the measurement errors follow Gaussian processes. In simulations and sensitivity analyses, we established some finite sample properties of these methods. In our simulations, both regression calibration methods for correcting measurement error performed better than estimators based on averaging the longitudinal functional data and using observations from a single day. We also applied the methods to assess the relationship between physical activity and type 2 diabetes in community dwelling adults in the United States who participated in the National Health and Nutrition Examination Survey.

stat.ME↗

arXiv2024

Adjusting for bias due to measurement error in functional quantile regression models with error-prone functional and scalar covariates

Wearable devices enable the continuous monitoring of physical activity (PA) but generate complex functional data with poorly characterized errors. Most work on functional data views the data as smooth, latent curves obtained at discrete time intervals with some random noise with mean zero and constant variance. Viewing this noise as homoscedastic and independent ignores potential serial correlations. Our preliminary studies indicate that failing to account for these serial correlations can bias estimations. In dietary assessments, epidemiologists often use self-reported measures based on food frequency questionnaires that are prone to recall bias. With the increased availability of complex, high-dimensional functional, and scalar biomedical data potentially prone to measurement errors, it is necessary to adjust for biases induced by these errors to permit accurate analyses in various regression settings. However, there has been limited work to address measurement errors in functional and scalar covariates in the context of quantile regression. Therefore, we developed new statistical methods based on simulation extrapolation (SIMEX) and mixed effects regression with repeated measures to correct for measurement error biases in this context. We conducted simulation studies to establish the finite sample properties of our new methods. The methods are illustrated through application to a real data set.

stat.ME↗

arXiv2023

Generalized functional linear regression models with a mixture of complex function-valued and scalar-valued covariates prone to measurement error

While extensive work has been done to correct for biases due to measurement error in scalar-valued covariates prone to errors in generalized linear regression models, limited work has been done to address biases associated with functional covariates prone to errors or the combination of scalar and functional covariates prone to errors in these models. We propose Simulation Extrapolation (SIMEX) and Regression Calibration approaches to correct measurement errors associated with a mixture of functional and scalar covariates prone to classical measurement errors in generalized functional linear regression. The simulation extrapolation method is developed to handle the functional and scalar covariates prone to errors. We also develop methods based on regression calibration extended to our current measurement error settings. Extensive simulation studies are conducted to assess the finite sample performance of our developed methods. The methods are applied to the 2011-2014 cycles of the National Health and Examination Survey data to assess the relationship between physical activity and total caloric intake with type 2 diabetes among community-dwelling adults living in the United States. We treat the device-based measures of physical activity as error-prone functional covariates prone to complex arbitrary heteroscedastic errors, while the total caloric intake is considered a scalar-valued covariate prone to error. We also examine the characteristics of observed measurement errors in device-based physical activity by important demographic subgroups including age, sex, and race.

stat.ME↗

arXiv2023

A Bayesian Semi-Parametric Scalar-On-Function Quantile Regression with Measurement Error using the GAL

Quantile regression provides a consistent approach to investigating the association between covariates and various aspects of the distribution of the response beyond the mean. When the regression covariates are measured with errors, measurement error (ME) adjustment steps are needed for valid inference. This is true for both scalar and functional covariates. Here, we propose extending the Bayesian measurement error and Bayesian quantile regression literature to allow for available covariates prone to potential complex measurement errors. Our approach uses the Generalized Asymmetric Laplace (GAL) distribution as a working likelihood. The family of GAL distribution has recently emerged as a more flexible distribution family in the Bayesian quantile regression modeling compared to their Asymmetric Laplace (AL) counterpart. We then compared and contrasted two approaches in our ME-adjusted steps through a battery of simulation scenarios. Finally, we apply our approach to the analysis of an NHANES dataset 2013-2014 to model quantiles of Body mass index (BMI) as a function of minute-level device-based physical activity in a cohort of an adult 50 years and above.

stat.ME↗

arXiv2022

A fully Bayesian semi-parametric scalar-on-function regression (SoFR) with measurement error using instrumental variables

Wearable devices such as the ActiGraph are now commonly used in health studies to monitor or track physical activity. This trend aligns well with the growing need to accurately assess the effects of physical activity on health outcomes such as obesity. When accessing the association between these device-based physical activity measures with health outcomes such as body mass index, the device-based data is considered functions, while the outcome is a scalar-valued. The regression model applied in these settings is the scalar-on-function regression (SoFR). Most estimation approaches in SoFR assume that the functional covariates are precisely observed, or the measurement errors are considered random errors. Violation of this assumption can lead to both under-estimation of the model parameters and sub-optimal analysis. The literature on a measurement corrected approach in SoFR is sparse in the non-Bayesian literature and virtually non-existent in the Bayesian literature. This paper considers a fully nonparametric Bayesian measurement error corrected SoFR model that relaxes all the constraining assumptions often made in these models. Our estimation relies on an instrumental variable (IV) to identify the measurement error model. Finally, we introduce an IV quality scalar parameter that is jointly estimated along with all model parameters. Our method is easy to implement, and we demonstrate its finite sample properties through an extensive simulation. Finally, the developed methods are applied to the National Health and Examination Survey to assess the relationship between wearable-device-based measures of physical activity and body mass index among adults living in the United States.

stat.ME↗