A systematic evaluation of machine learning classifiers for event-by-event background rejection in LAFOV PET scanners
The introduction of LAFOV PET scanners brings significant sensitivity gains but also a substantial increase in the background rate from accidental coincidences, phantom-scattered and detector-scattered photons. While machine learning methods have been applied to background reduction in PET imaging, they target specific background components in post-processing rather than event-by-event classification on the raw data. In this work, we formulate coincidence classification as a supervised multi-class problem and evaluate XGBoost, AdaBoost and Neural Network classifiers as pre-reconstruction filters, using Monte Carlo simulations of the Siemens Biograph Vision Quadra scanner with NEMA IEC and anthropomorphic XCAT phantoms. We investigate two feature sets: a 4-feature representation based on the Attenuation Factor, photon time difference, energy sum, and energy difference, and an extended 6-feature set that incorporates topology-based variables. A systematic robustness study via cross-phantom inference reveals that the 4-feature models generalise significantly better across different phantom geometries, with XGBoost suffering an accuracy loss of only 0.04 compared to 0.13 for the 6-feature variant. Our best models achieve accuracies of up to 0.74 and 0.69 for the NEMA IEC and XCAT phantoms, respectively, outperforming traditional geometry-based cuts. However, we show that this compact feature set not only provides limited suppression of in-phantom scattered coincidences, but it also can lead to non-trivial spatial patterns. With scattered coincidences being the dominant background component in clinical conditions, this suggests that while the method serves as an effective and geometry-agnostic replacement for traditional cut-based selection, meaningful further gains in image quality will require either larger input representations or dedicated treatment of the phantom-scattered component.