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Ronald Jansen

Publications and source records attributed to Ronald Jansen.

2 recordsLinked to original sources

UN Handbook on Privacy-Preserving Computation Techniques

This paper describes privacy-preserving approaches for the statistical analysis. It describes motivations for privacy-preserving approaches for the statistical analysis of sensitive data, presents examples of use cases where such methods may apply and describes relevant technical capabilities to assure privacy preservation while still allowing analysis of sensitive data. Our focus is on methods that enable protecting privacy of data while it is being processed, not only while it is at rest on a system or in transit between systems. The information in this document is intended for use by statisticians and data scientists, data curators and architects, IT specialists, and security and information assurance specialists, so we explicitly avoid cryptographic technical details of the technologies we describe.

cs.CY

Signal processing in the TGF-beta superfamily ligand-receptor network

The TGF-beta pathway plays a central role in tissue homeostasis and morphogenesis. It transduces a variety of extracellular signals into intracellular transcriptional responses that control a plethora of cellular processes, including cell growth, apoptosis, and differentiation. We use computational modeling to show that coupling of signaling with receptor trafficking results in a highly versatile signal-processing unit, able to sense by itself absolute levels of ligand, temporal changes in ligand concentration, and ratios of multiple ligands. This coupling controls whether the response of the receptor module is transient or permanent and whether or not different signaling channels behave independently of each other. Our computational approach unifies seemingly disparate experimental observations and suggests specific changes in receptor trafficking patterns that can lead to phenotypes that favor tumor progression.

q-bio.MN