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Rossana Droghetti

Publications and source records attributed to Rossana Droghetti.

2 recordsLinked to original sources

Component systems: do null models explain everything?

Component systems - ensembles of realizations built from a shared repertoire of modular parts - are ubiquitous in biological, ecological, technological, and socio-cultural domains. From genomes to texts, cities, and software, these systems exhibit statistical regularities that often meet the "bona fide" requirements of laws in the physical sciences. Here, we argue that the generality and simplicity of those laws are often due to basic combinatorial or sampling constraints, raising the question of whether such patterns are actually revealing system-specific mechanisms and how we might move beyond them. To this end, we first present a unifying mathematical framework, which allows us to compare modular systems in different fields and highlights the common "null" trends as well as the system-specific uniqueness, which, arguably, are signatures of the underlying generative dynamics. Next, we can exploit the framework with statistical mechanics and modern machine-learning tools for a twofold objective. (i) Explaining why the general regularities emerge, highlighting the constraints between them and the general principles at their origins, and (ii) "subtracting" them from data, which will isolate the informative features for inferring hidden system-specific generative processes, mechanistic and causal aspects.

cond-mat.stat-mech

The Hands-On Growth Laws Theory Cookbook

This tutorial covers the emerging field of coarse-grained cellular growth modeling, and aims to bridge the gap between theoretical foundations and practical application. By adopting an original "cookbook" approach, it is designed to offer a hands-on guide for constructing and analyzing different key aspects of cellular growth, focusing on available results for bacteria and beyond. The tutorial is structured as a series of step-by-step "recipes", and covers essential concepts, recent literature, and key challenges. It aims to empower a broad audience, from students to seasoned researchers, to replicate, extend, and innovate in this scientific area. Specifically, each section provides detailed, bare-bone models to start working in each area, from basic steady-state growth to variable environments and focusing on different key layers relevant to biosynthesis, transcription, translation, nutrient sensing and protein degradation, links between cell cycle and growth, ending with ecological insights.

q-bio.OT