arXiv subjects

Rui Sheng

Publications and source records attributed to Rui Sheng.

27 records · Page 2Linked to original sources

arXiv2026

MedKGI: Iterative Differential Diagnosis with Medical Knowledge Graphs and Information-Guided Inquiring

Recent advancements in Large Language Models (LLMs) have demonstrated significant promise in clinical diagnosis. However, current models struggle to emulate the iterative, diagnostic hypothesis-driven reasoning of real clinical scenarios. Specifically, current LLMs suffer from three critical limitations: (1) generating hallucinated medical content due to weak grounding in verified knowledge, (2) asking redundant or inefficient questions rather than discriminative ones that hinder diagnostic progress, and (3) losing coherence over multi-turn dialogues, leading to contradictory or inconsistent conclusions. To address these challenges, we propose MedKGI, a diagnostic framework grounded in clinical practices. MedKGI integrates a medical knowledge graph (KG) to constrain reasoning to validated medical ontologies, selects questions based on information gain to maximize diagnostic efficiency, and adopts an OSCE-format structured state to maintain consistent evidence tracking across turns. Experiments on clinical benchmarks show that MedKGI outperforms strong LLM baselines in both diagnostic accuracy and inquiry efficiency, improving dialogue efficiency by 30% on average while maintaining state-of-the-art accuracy.

cs.CL↗

arXiv2025

EMINDS: Understanding User Behavior Progression for Mental Health Exploration on Social Media

Mental health is an urgent societal issue, and social scientists are increasingly turning to online mental health communities (OMHCs) to analyze user behavior data for early intervention. However, existing sequence mining techniques fall short of the urgent need to explore the behavior progression of different groups (e.g., recovery or deterioration groups) and track the potential long-term impact of behaviors on mental health status. To address this issue, we introduce EMINDS, a visual analytics system built on a novel automatic mining pipeline that extracts distinct behavior stages and assesses the potential impact of frequent stage patterns on mental health status over time. The system includes a set of interactive visualizations that summarize the meaning of each behavior stage and the evolution of different stage patterns. We feature a pattern-centric Sankey diagram to reveal contextual information about the impact of stage patterns on mental health, helping experts understand the specific changes in sequences before and after a stage pattern. We evaluated the effectiveness and usability of EMINDS through two case studies and expert interviews, which examined the potential stage patterns impacting long-term mental health by analyzing user behaviors on Reddit.

cs.HC↗

arXiv2025

CellScout: Visual Analytics for Mining Biomarkers in Cell State Discovery

Cell state discovery is crucial for understanding biological systems and enhancing medical outcomes. A key aspect of this process is identifying distinct biomarkers that define specific cell states. However, difficulties arise from the co-discovery process of cell states and biomarkers: biologists often use dimensionality reduction to visualize cells in a two-dimensional space. Then they usually interpret visually clustered cells as distinct states, from which they seek to identify unique biomarkers. However, this assumption is often invalid due to internal inconsistencies in a cluster, making the process trial-and-error and highly uncertain. Therefore, biologists urgently need effective tools to help uncover the hidden association relationships between different cell populations and their potential biomarkers. To address this problem, we first designed a machine-learning algorithm based on the Mixture-of-Experts (MoE) technique to identify meaningful associations between cell populations and biomarkers. We further developed a visual analytics system, CellScout, in collaboration with biologists, to help them explore and refine these association relationships to advance cell state discovery. We validated our system through expert interviews, from which we further selected a representative case to demonstrate its effectiveness in discovering new cell states.

cs.HC↗

arXiv2025

Unmasking Deceptive Visuals: Benchmarking Multimodal Large Language Models on Misleading Chart Question Answering

Misleading visualizations, which manipulate chart representations to support specific claims, can distort perception and lead to incorrect conclusions. Despite decades of research, they remain a widespread issue, posing risks to public understanding and raising safety concerns for AI systems involved in data-driven communication. While recent multimodal large language models (MLLMs) show strong chart comprehension abilities, their capacity to detect and interpret misleading charts remains unexplored. We introduce Misleading ChartQA benchmark, a large-scale multimodal dataset designed to evaluate MLLMs on misleading chart reasoning. It contains 3,026 curated examples spanning 21 misleader types and 10 chart types, each with standardized chart code, CSV data, multiple-choice questions, and labeled explanations, validated through iterative MLLM checks and expert human review. We benchmark 24 state-of-the-art MLLMs, analyze their performance across misleader types and chart formats, and propose a novel region-aware reasoning pipeline that enhances model accuracy. Our work lays the foundation for developing MLLMs that are robust, trustworthy, and aligned with the demands of responsible visual communication.

cs.CL↗

arXiv2025

SciDaSynth: Interactive Structured Data Extraction from Scientific Literature with Large Language Model

The explosion of scientific literature has made the efficient and accurate extraction of structured data a critical component for advancing scientific knowledge and supporting evidence-based decision-making. However, existing tools often struggle to extract and structure multimodal, varied, and inconsistent information across documents into standardized formats. We introduce SciDaSynth, a novel interactive system powered by large language models (LLMs) that automatically generates structured data tables according to users' queries by integrating information from diverse sources, including text, tables, and figures. Furthermore, SciDaSynth supports efficient table data validation and refinement, featuring multi-faceted visual summaries and semantic grouping capabilities to resolve cross-document data inconsistencies. A within-subjects study with nutrition and NLP researchers demonstrates SciDaSynth's effectiveness in producing high-quality structured data more efficiently than baseline methods. We discuss design implications for human-AI collaborative systems supporting data extraction tasks. The system code is available at https://github.com/xingbow/SciDaEx

cs.HC↗

arXiv2025

Qualitative Study for LLM-assisted Design Study Process: Strategies, Challenges, and Roles

Design studies aim to create visualization solutions for real-world problems of different application domains. Recently, the emergence of large language models (LLMs) has introduced new opportunities to enhance the design study process, providing capabilities such as creative problem-solving, data handling, and insightful analysis. However, despite their growing popularity, there remains a lack of systematic understanding of how LLMs can effectively assist researchers in visualization-specific design studies. In this paper, we conducted a multi-stage qualitative study to fill this gap, involving 30 design study researchers from diverse backgrounds and expertise levels. Through in-depth interviews and carefully-designed questionnaires, we investigated strategies for utilizing LLMs, the challenges encountered, and the practices used to overcome them. We further compiled and summarized the roles that LLMs can play across different stages of the design study process. Our findings highlight practical implications to inform visualization practitioners, and provide a framework for leveraging LLMs to enhance the design study process in visualization research.

cs.HC↗

arXiv2025

TrajLens: Visual Analysis for Constructing Cell Developmental Trajectories in Cross-Sample Exploration

Constructing cell developmental trajectories is a critical task in single-cell RNA sequencing (scRNA-seq) analysis, enabling the inference of potential cellular progression paths. However, current automated methods are limited to establishing cell developmental trajectories within individual samples, necessitating biologists to manually link cells across samples to construct complete cross-sample evolutionary trajectories that consider cellular spatial dynamics. This process demands substantial human effort due to the complex spatial correspondence between each pair of samples. To address this challenge, we first proposed a GNN-based model to predict cross-sample cell developmental trajectories. We then developed TrajLens, a visual analytics system that supports biologists in exploring and refining the cell developmental trajectories based on predicted links. Specifically, we designed the visualization that integrates features on cell distribution and developmental direction across multiple samples, providing an overview of the spatial evolutionary patterns of cell populations along trajectories. Additionally, we included contour maps superimposed on the original cell distribution data, enabling biologists to explore them intuitively. To demonstrate our system's performance, we conducted quantitative evaluations of our model with two case studies and expert interviews to validate its usefulness and effectiveness.

cs.CG↗

arXiv2025

SynthLens: Visual Analytics for Facilitating Multi-step Synthetic Route Design

Designing synthetic routes for novel molecules is pivotal in various fields like medicine and chemistry. In this process, researchers need to explore a set of synthetic reactions to transform starting molecules into intermediates step by step until the target novel molecule is obtained. However, designing synthetic routes presents challenges for researchers. First, researchers need to make decisions among numerous possible synthetic reactions at each step, considering various criteria (e.g., yield, experimental duration, and the count of experimental steps) to construct the synthetic route. Second, they must consider the potential impact of one choice at each step on the overall synthetic route. To address these challenges, we proposed SynthLens, a visual analytics system to facilitate the iterative construction of synthetic routes by exploring multiple possibilities for synthetic reactions at each step of construction. Specifically, we have introduced a tree-form visualization in SynthLens to compare and evaluate all the explored routes at various exploration steps, considering both the exploration step and multiple criteria. Our system empowers researchers to consider their construction process comprehensively, guiding them toward promising exploration directions to complete the synthetic route. We validated the usability and effectiveness of SynthLens through a quantitative evaluation and expert interviews, highlighting its role in facilitating the design process of synthetic routes. Finally, we discussed the insights of SynthLens to inspire other multi-criteria decision-making scenarios with visual analytics.

cs.HC↗

arXiv2024

Solving the inverse source problem of the fractional Poisson equation by MC-fPINNs

In this paper, we effectively solve the inverse source problem of the fractional Poisson equation using MC-fPINNs. We construct two neural networks $ u_{NN}(x;θ)$ and $f_{NN}(x;ψ)$ to approximate the solution $u^{*}(x)$ and the forcing term $f^{*}(x)$ of the fractional Poisson equation. To optimize these two neural networks, we use the Monte Carlo sampling method mentioned in MC-fPINNs and define a new loss function combining measurement data and the underlying physical model. Meanwhile, we present a comprehensive error analysis for this method, along with a prior rule to select the appropriate parameters of neural networks. Several numerical examples are given to demonstrate the great precision and robustness of this method in solving high-dimensional problems up to 10D, with various fractional order $α$ and different noise levels of the measurement data ranging from 1$\%$ to 10$\%$.

math.NA↗