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Ruoyu Xue

Publications and source records attributed to Ruoyu Xue.

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Pathologist Attention-Aligned Report Generation for Prostate Histopathology

The allocation of visual attention by pathologists during cancer diagnosis is a highly selective process that critically shapes the information extracted from whole-slide images (WSIs). Human attention helps medical imaging tasks such as classification and segmentation, and becomes a strong semantic cue for identifying diagnostically informative regions for report generation. In this paper, we introduce human attention into the training of pathologist report generation models. To this end, we collected a multimodal human-attention dataset of 121 prostate WSIs annotated with pathologists' multi-scale viewport trajectories synchronized with the pathologists' verbal descriptions and cursor movements for five clinically relevant components (e.g., Gleason patterns). Using this dataset, we finetune two report generation models with an attention-alignment loss that regularizes the model attention over image patches to match the distribution of pathologist attention. We evaluate our approach on prostate cancer report generation and visual question answering using two models with different internal attention mechanisms (i.e., how image tokens are integrated into the language decoder). Experiments show average gains of 10.9% on NLP-based metrics and 19.3% in accuracy across five clinically relevant report components. Further, model attention maps extracted at inference time, with minimal computational overhead, align more closely with pathologist attention, providing stronger visual support for the generated reports by highlighting the regions that most influence the output.

cs.CV

Personalized Image Descriptions from Attention Sequences

People can view the same image differently: they focus on different regions, objects, and details in varying orders and describe them in distinct linguistic styles. This leads to substantial variability in image descriptions. However, existing models for personalized image description focus on linguistic style alone, with no prior work leveraging individual viewing patterns. We address this gap by explicitly modeling personalized viewing behavior as a core factor in description generation. Our method, DEPER (DEscription-PERception persona encoder), learns a subject embedding that captures both linguistic style and viewing behavior, guided by an auxiliary attention-prediction task. A lightweight adapter aligns these embeddings with a frozen vision-language model, enabling few-shot personalization without retraining. Across four datasets spanning diverse viewing tasks and both short and detailed descriptions, DEPER achieves a 24% average improvement, showing that modeling personalized attention produces more human-aligned and high-quality descriptions. We posit that understanding how people see helps predict what they say; modeling human diversity in perception can improve both performance and human alignment in multimodal systems.

cs.CV

Measuring and Predicting Where and When Pathologists Focus their Visual Attention while Grading Whole Slide Images of Cancer

The ability to predict the attention of expert pathologists could lead to decision support systems for better pathology training. We developed methods to predict the spatio-temporal (where and when) movements of pathologists' attention as they grade whole slide images (WSIs) of prostate cancer. We characterize a pathologist's attention trajectory by their x, y, and m (magnification) movements of a viewport as they navigate WSIs using a digital microscope. This information was obtained from 43 pathologists across 123 WSIs, and we consider the task of predicting the pathologist attention scanpaths constructed from the viewport centers. We introduce a fixation extraction algorithm that simplifies an attention trajectory by extracting fixations in the pathologist's viewing while preserving semantic information, and we use these pre-processed data to train and test a two-stage model to predict the dynamic (scanpath) allocation of attention during WSI reading via intermediate attention heatmap prediction. In the first stage, a transformer-based sub-network predicts the attention heatmaps (static attention) across different magnifications. In the second stage, we predict the attention scanpath by sequentially modeling the next fixation points in an autoregressive manner using a transformer-based approach, starting at the WSI center and leveraging multi-magnification feature representations from the first stage. Experimental results show that our scanpath prediction model outperforms chance and baseline models. Tools developed from this model could assist pathology trainees in learning to allocate their attention during WSI reading like an expert.

eess.IV

Few-shot Personalized Scanpath Prediction

A personalized model for scanpath prediction provides insights into the visual preferences and attention patterns of individual subjects. However, existing methods for training scanpath prediction models are data-intensive and cannot be effectively personalized to new individuals with only a few available examples. In this paper, we propose few-shot personalized scanpath prediction task (FS-PSP) and a novel method to address it, which aims to predict scanpaths for an unseen subject using minimal support data of that subject's scanpath behavior. The key to our method's adaptability is the Subject-Embedding Network (SE-Net), specifically designed to capture unique, individualized representations for each subject's scanpaths. SE-Net generates subject embeddings that effectively distinguish between subjects while minimizing variability among scanpaths from the same individual. The personalized scanpath prediction model is then conditioned on these subject embeddings to produce accurate, personalized results. Experiments on multiple eye-tracking datasets demonstrate that our method excels in FS-PSP settings and does not require any fine-tuning steps at test time. Code is available at: https://github.com/cvlab-stonybrook/few-shot-scanpath

cs.CV

Unifying Top-down and Bottom-up Scanpath Prediction Using Transformers

Most models of visual attention aim at predicting either top-down or bottom-up control, as studied using different visual search and free-viewing tasks. In this paper we propose the Human Attention Transformer (HAT), a single model that predicts both forms of attention control. HAT uses a novel transformer-based architecture and a simplified foveated retina that collectively create a spatio-temporal awareness akin to the dynamic visual working memory of humans. HAT not only establishes a new state-of-the-art in predicting the scanpath of fixations made during target-present and target-absent visual search and ``taskless'' free viewing, but also makes human gaze behavior interpretable. Unlike previous methods that rely on a coarse grid of fixation cells and experience information loss due to fixation discretization, HAT features a sequential dense prediction architecture and outputs a dense heatmap for each fixation, thus avoiding discretizing fixations. HAT sets a new standard in computational attention, which emphasizes effectiveness, generality, and interpretability. HAT's demonstrated scope and applicability will likely inspire the development of new attention models that can better predict human behavior in various attention-demanding scenarios. Code is available at https://github.com/cvlab-stonybrook/HAT.

cs.CV