arXiv subjects

Russ Altman

Publications and source records attributed to Russ Altman.

7 recordsLinked to original sources

arXiv2026

Artificial Intelligence Index Report 2026

Welcome to the ninth edition of the AI Index report. As AI continues to advance rapidly, the question becomes whether the systems built around it can keep up. Governance frameworks, evaluation methods, education systems, and the data infrastructure needed to track AI's impact are struggling to match the pace of the technology itself. That gap between what AI can do and how prepared we are to manage it runs through every chapter of this year's report. New in this edition, the report tracks how AI is being tested more ambitiously across reasoning, safety, and real-world task execution, and why those measurements are increasingly difficult to rely on. It also features new estimates of generative AI's economic value alongside emerging evidence of its labor market effects, an analytical framework on AI sovereignty, and a science chapter developed in collaboration with Schmidt Sciences. For the first time, the report features standalone chapters on AI in science and AI in medicine, reflecting AI's growing impact across these two domains.

cs.AI↗

arXiv2025

Generative AI for Biosciences: Emerging Threats and Roadmap to Biosecurity

The rapid adoption of generative artificial intelligence (GenAI) in the biosciences is transforming biotechnology, medicine, and synthetic biology. Yet this advancement is intrinsically linked to new vulnerabilities, as GenAI lowers the barrier to misuse and introduces novel biosecurity threats, such as generating synthetic viral proteins or toxins. These dual-use risks are often overlooked, as existing safety guardrails remain fragile and can be circumvented through deceptive prompts or jailbreak techniques. In this Perspective, we first outline the current state of GenAI in the biosciences and emerging threat vectors ranging from jailbreak attacks and privacy risks to the dual-use challenges posed by autonomous AI agents. We then examine urgent gaps in regulation and oversight, drawing on insights from 130 expert interviews across academia, government, industry, and policy. A large majority ($\approx 76$\%) expressed concern over AI misuse in biology, and 74\% called for the development of new governance frameworks. Finally, we explore technical pathways to mitigation, advocating a multi-layered approach to GenAI safety. These defenses include rigorous data filtering, alignment with ethical principles during development, and real-time monitoring to block harmful requests. Together, these strategies provide a blueprint for embedding security throughout the GenAI lifecycle. As GenAI becomes integrated into the biosciences, safeguarding this frontier requires an immediate commitment to both adaptive governance and secure-by-design technologies.

cs.CR↗

arXiv2025

Detecting clinician implicit biases in diagnoses using proximal causal inference

Clinical decisions to treat and diagnose patients are affected by implicit biases formed by racism, ableism, sexism, and other stereotypes. These biases reflect broader systemic discrimination in healthcare and risk marginalizing already disadvantaged groups. Existing methods for measuring implicit biases require controlled randomized testing and only capture individual attitudes rather than outcomes. However, the "big-data" revolution has led to the availability of large observational medical datasets, like EHRs and biobanks, that provide the opportunity to investigate discrepancies in patient health outcomes. In this work, we propose a causal inference approach to detect the effect of clinician implicit biases on patient outcomes in large-scale medical data. Specifically, our method uses proximal mediation to disentangle pathway-specific effects of a patient's sociodemographic attribute on a clinician's diagnosis decision. We test our method on real-world data from the UK Biobank. Our work can serve as a tool that initiates conversation and brings awareness to unequal health outcomes caused by implicit biases.

cs.LG↗

arXiv2024

Individual Fairness Through Reweighting and Tuning

Inherent bias within society can be amplified and perpetuated by artificial intelligence (AI) systems. To address this issue, a wide range of solutions have been proposed to identify and mitigate bias and enforce fairness for individuals and groups. Recently, Graph Laplacian Regularizer (GLR), a regularization technique from the semi-supervised learning literature has been used as a substitute for the common Lipschitz condition to enhance individual fairness. Notable prior work has shown that enforcing individual fairness through a GLR can improve the transfer learning accuracy of AI models under covariate shifts. However, the prior work defines a GLR on the source and target data combined, implicitly assuming that the target data are available at train time, which might not hold in practice. In this work, we investigated whether defining a GLR independently on the train and target data could maintain similar accuracy. Furthermore, we introduced the Normalized Fairness Gain score (NFG) to measure individual fairness by measuring the amount of gained fairness when a GLR is used versus not. We evaluated the new and original methods under NFG, the Prediction Consistency (PC), and traditional classification metrics on the German Credit Approval dataset. The results showed that the two models achieved similar statistical mean performances over five-fold cross-validation. Furthermore, the proposed metric showed that PC scores can be misleading as the scores can be high and statistically similar to fairness-enhanced models while NFG scores are small. This work therefore provides new insights into when a GLR effectively enhances individual fairness and the pitfalls of PC.

cs.LG↗

arXiv2024

Prospector Heads: Generalized Feature Attribution for Large Models & Data

Feature attribution, the ability to localize regions of the input data that are relevant for classification, is an important capability for ML models in scientific and biomedical domains. Current methods for feature attribution, which rely on "explaining" the predictions of end-to-end classifiers, suffer from imprecise feature localization and are inadequate for use with small sample sizes and high-dimensional datasets due to computational challenges. We introduce prospector heads, an efficient and interpretable alternative to explanation-based attribution methods that can be applied to any encoder and any data modality. Prospector heads generalize across modalities through experiments on sequences (text), images (pathology), and graphs (protein structures), outperforming baseline attribution methods by up to 26.3 points in mean localization AUPRC. We also demonstrate how prospector heads enable improved interpretation and discovery of class-specific patterns in input data. Through their high performance, flexibility, and generalizability, prospectors provide a framework for improving trust and transparency for ML models in complex domains.

cs.LG↗

arXiv2022

Gene set proximity analysis: expanding gene set enrichment analysis through learned geometric embeddings

Gene set analysis methods rely on knowledge-based representations of genetic interactions in the form of both gene set collections and protein-protein interaction (PPI) networks. Explicit representations of genetic interactions often fail to capture complex interdependencies among genes, limiting the analytic power of such methods. Here we propose an extension of gene set enrichment analysis to a latent feature space reflecting PPI network topology, called gene set proximity analysis (GSPA). Compared with existing methods, GSPA provides improved ability to identify disease-associated pathways in disease-matched gene expression datasets, while improving reproducibility of enrichment statistics for similar gene sets. GSPA is statistically straightforward, reducing to classical gene set enrichment through a single user-defined parameter. We apply our method to identify novel drug associations with SARS-CoV-2 viral entry. Finally, we validate our drug association predictions through retrospective clinical analysis of claims data from 8 million patients, supporting a role for gabapentin as a risk factor and metformin as a protective factor for COVID-19 hospitalization.

q-bio.QM↗

arXiv2021

On the Opportunities and Risks of Foundation Models

AI is undergoing a paradigm shift with the rise of models (e.g., BERT, DALL-E, GPT-3) that are trained on broad data at scale and are adaptable to a wide range of downstream tasks. We call these models foundation models to underscore their critically central yet incomplete character. This report provides a thorough account of the opportunities and risks of foundation models, ranging from their capabilities (e.g., language, vision, robotics, reasoning, human interaction) and technical principles(e.g., model architectures, training procedures, data, systems, security, evaluation, theory) to their applications (e.g., law, healthcare, education) and societal impact (e.g., inequity, misuse, economic and environmental impact, legal and ethical considerations). Though foundation models are based on standard deep learning and transfer learning, their scale results in new emergent capabilities,and their effectiveness across so many tasks incentivizes homogenization. Homogenization provides powerful leverage but demands caution, as the defects of the foundation model are inherited by all the adapted models downstream. Despite the impending widespread deployment of foundation models, we currently lack a clear understanding of how they work, when they fail, and what they are even capable of due to their emergent properties. To tackle these questions, we believe much of the critical research on foundation models will require deep interdisciplinary collaboration commensurate with their fundamentally sociotechnical nature.

cs.LG↗