Dose-Aware Cold Diffusion with Physics Consistency for Generalizable Low-Dose CT Reconstruction
Reducing radiation dose in computed tomography significantly degrades image quality and poses challenges for accurate and clinically reliable reconstruction. While recent approaches have shown promise for low-dose CT, they often struggle to generalize across continuous and previously unseen dose levels, leading to artifacts and loss of anatomical detail. To address these limitations, we propose Dose-Aware Cold Diffusion (DACD), a physics-consistent reconstruction framework that explicitly models radiation dose as a continuous latent factor within a cold diffusion process. The proposed DACD framework integrates image-based dose-aware perception, multi-scale structural prior extraction, and dose-calibrated step allocation to adaptively guide the denoising trajectory. In addition, an iterative forward-backprojection correction is incorporated into the reverse refinement process to enforce projection-domain data consistency. Extensive experiments on three public benchmarks, including Mayo-2020, Mayo-2016, and LoDoPaB-CT, demonstrate that DACD consistently outperforms state-of-the-art diffusion-based and physics-guided methods in both quantitative accuracy and visual fidelity, particularly under ultra-low-dose conditions. The results show that DACD achieves robust generalization across a continuous range of dose levels, including those unseen during training.