arXiv subjects
Publications and source records attributed to S. Endres.
We calculate dilepton spectra in heavy-ion collisions using a coarse-graining approach to the simulation of the created medium with the UrQMD transport model. This enables the use of dilepton-production rates evaluated in equilibrium quantum-field theory at finite temperatures and chemical potentials.
Multifunctional mesoporous silica nanoparticles (MSN) have attracted substantial attention with regard to their high potential for targeted drug delivery. For future clinical applications it is crucial to address safety concerns and understand the potential immunotoxicity of these nanoparticles. In this study, we assess the biocompatibility and functionality of multifunctional MSN in freshly isolated, primary murine immune cells. We show that the functionalized silica nanoparticles are rapidly and efficiently taken up into the endosomal compartment by specialized antigen-presenting cells such as dendritic cells. The silica nanoparticles showed a favorable toxicity profile and did not affect the viability of primary immune cells from the spleen in relevant concentrations. Cargo-free MSN induced only very low immune responses in primary cells as determined by surface expression of activation markers and release of pro-inflammatory cytokines such as Interleukin-6, -12 and -1β. In contrast, when surface-functionalized MSN with a pH-responsive polymer capping were loaded with an immune-activating drug, the synthetic Toll-like receptor 7 agonist R848, a strong immune response was provoked. We thus demonstrate that MSN represent an efficient drug delivery vehicle to primary immune cells that is both non-toxic and non-inflammagenic, which is a prerequisite for the use of these particles in biomedical applications.
Due to their penetrating nature, electromagnetic probes, i.e., lepton-antilepton pairs (dileptons) and photons are unique tools to gain insight into the nature of the hot and dense medium of strongly-interacting particles created in relativistic heavy-ion collisions, including hints to the nature of the restoration of chiral symmetry of QCD. Of particular interest are the spectral properties of the electromagnetic current-correlation function of these particles within the dense and/or hot medium. The related theoretical investigations of the in-medium properties of the involved particles in both the partonic and hadronic part of the QCD phase diagram underline the importance of a proper understanding of the properties of various hadron resonances in the medium.