Fabrication Of Bilayer Nanofibers From Poly Xylitol Dodecanedioic Acid, Poly Caprolactone, Gelatin Biological Macromolecules And Surface Modification Via Spin Coating Of Capsules For Skin Wound Treatment
In this study, poly xylitol dodecanedioic acid was synthesized from xylitol and dodecanedioic acid monomers in a 1:1 molar ratio with Mw = 4038 g/mol using the polycondensation method. bilayer nanofibers with optimal morphology and average diameter of 271 70 nm were fabricated using electrospinning in voltage of 15 kV and flow rate of 0.5 ml/h, incorporating 15% PXDDA, 15% gelatin, and 20% poly caprolactone polymer solutions. this diameter of nanofibers was perfectly aligned with genetic algorithm in ANN model with a cost value of 0.0054 and R = 0.99 rather than RSM model. to enhance the stability of the electrospun nanofibers, glutaraldehyde was employed as a crosslinking agent. additionally, nitrogen doped activated carbon nanoparticles served as carriers for clindamycin, intended for spin coating between the layers of PXDDA/Gel/PCL nanofibers. Results indicated that an increase in capsule concentration enhanced bilayer nanofiber contact angle while swelling percentage progressively increased in optimal point of CD concentration over 12 hours. furthermore, drug release followed higuchi kinetics, exhibiting high correlation values for the best-fit model. biodegradability, antibacterial efficacy, cell culture assessments, and MTT assay demonstrated optimizing drug concentration improved cell attachment and viability compared to the control sample.