arXiv subjects

S. Heinrich

Publications and source records attributed to S. Heinrich.

3 recordsLinked to original sources

arXiv2024

Laser-FLASH: radiobiology at high dose, ultra-high dose-rate, single pulse laser-driven proton source

Laser-driven proton sources have long been developed with an eye on their potential for medical application to radiation therapy. These sources are compact, versatile, and show peculiar characteristics such as extreme instantaneous dose rates, short duration and broad energy spectrum. Typical temporal modality of laser-driven irradiation, the so-called fast-fractionation, results from the composition of multiple, temporally separated, ultra-short dose fractions. In this paper we present the use of a high-energy laser system for delivering the target dose in a single nanosecond pulse, for ultra-fast irradiation of biological samples. A transport line composed by two permanent magnet quadrupoles and a scattering system is used to improve the dose profile and to control the delivered dose-per-pulse. A single-shot dosimetry protocol for the broad-spectrum proton source using Monte Carlo simulations was developed. Doses as high as 20Gy could be delivered in a single shot, lasting less than 10ns over a 1.0cm diameter sample holder, at a dose-rate exceeding 10^9 Gy/s. Exploratory application of extreme laser-driven irradiation conditions, falling within the FLASH irradiation protocol, are presented for in vitro and in vivo irradiation. A reduction of radiation-induced oxidative stress in-vitro and radiation-induced developmental damage in vivo were observed, whereas anti-tumoral efficacy was confirmed by cell survival assay.

physics.med-ph↗

arXiv2005

An Agent-based Manufacturing Management System for Production and Logistics within Cross-Company Regional and National Production Networks

The goal is the development of a simultaneous, dynamic, technological as well as logistical real-time planning and an organizational control of the production by the production units themselves, working in the production network under the use of Multi-Agent-Technology. The design of the multi-agent-based manufacturing management system, the models of the single agents, algorithms for the agent-based, decentralized dispatching of orders, strategies and data management concepts as well as their integration into the SCM, basing on the solution described, will be explained in the following. Keywords: production engineering and management, dynamic manufacturing planning and control, multi-agentsystems (MAS), supply-chain-management (SCM), e-manufacturing

cs.RO↗

arXiv2001

Optimal Summation and Integration by Deterministic, Randomized, and Quantum Algorithms

We survey old and new results about optimal algorithms for summation of finite sequences and for integration of functions from Hoelder or Sobolev spaces. First we discuss optimal deterministic and randomized algorithms. Then we add a new aspect, which has not been covered before on conferences about (quasi-) Monte Carlo methods: quantum computation. We give a short introduction into this setting and present recent results of the authors on optimal quantum algorithms for summation and integration. We discuss comparisons between the three settings. The most interesting case for Monte Carlo and quantum integration is that of moderate smoothness k and large dimension d which, in fact, occurs in a number of important applied problems. In that case the deterministic exponent is negligible, so the n^{-1/2} Monte Carlo and the n^{-1} quantum speedup essentially constitute the entire convergence rate. We observe that -- there is an exponential speed-up of quantum algorithms over deterministic (classical) algorithms, if k/d tends to zero; -- there is a (roughly) quadratic speed-up of quantum algorithms over randomized classical algorithms, if k/d is small.

quant-ph↗