Combination anti-coronavirus therapies based on nonlinear mathematical models
Using nonlinear mathematical models and experimental data from laboratory and clinical studies, we have designed new combination therapies against COVID-19.
arXiv subjects
Publications and source records attributed to S. Jimenez.
Using nonlinear mathematical models and experimental data from laboratory and clinical studies, we have designed new combination therapies against COVID-19.
A detailed understanding of wind turbine performance status classification can improve operations and maintenance in the wind energy industry. Due to different engineering properties of wind turbines, the standard supervised learning models used for classification do not generalize across data sets obtained from different wind sites. We propose two methods to deal with the transferability of the trained models: first, data normalization in the form of power curve alignment, and second, a robust method based on convolutional neural networks and feature-space extension. We demonstrate the success of our methods on real-world data sets with industrial applications.
A 10 kilo-tonne dual-phase liquid argon TPC is one of the detector options considered for the Deep Underground Neutrino Experiment (DUNE). The detector technology relies on amplification of the ionisation charge in ultra-pure argon vapour and oers several advantages compared to the traditional single-phase liquid argon TPCs. A 4.2 tonne dual-phase liquid argon TPC prototype, the largest of its kind, with an active volume of 3x1x1 $m^3$ has been constructed and operated at CERN. In this paper we describe in detail the experimental setup and detector components as well as report on the operation experience. We also present the first results on the achieved charge amplification, prompt scintillation and electroluminescence detection, and purity of the liquid argon from analyses of a collected sample of cosmic ray muons.
We introduce an effective scalar field theory to describe the He-IV phase diagram, which can be considered as a generalization of the XY model which gives the usual lambda-transition. This theory results from a Ginzburg-Landau Hamiltonian with higher order derivatives, which allow to produce transitions between the superfluid, normal liquid and solid phases of He-IV. Mean field and Monte Carlo analyses suggest that this model is able to reproduce the main qualitative features of He-IV phase transitions.
Dedicated machines designed for specific computational algorithms can outperform conventional computers by several orders of magnitude. In this note we describe {\it Ianus}, a new generation FPGA based machine and its basic features: hardware integration and wide reprogrammability. Our goal is to build a machine that can fully exploit the performance potential of new generation FPGA devices. We also plan a software platform which simplifies its programming, in order to extend its intended range of application to a wide class of interesting and computationally demanding problems. The decision to develop a dedicated processor is a complex one, involving careful assessment of its performance lead, during its expected lifetime, over traditional computers, taking into account their performance increase, as predicted by Moore's law. We discuss this point in detail.
We numerically study aging for the Edwards-Anderson Model in 3 and 4 dimensions using different temperature-change protocols. In D=3, time scales a thousand times larger than in previous work are reached with the SUE machine. Deviations from cumulative aging are observed in the non monotonic time behavior of the coherence length. Memory and rejuvenation effects are found in a temperature-cycle protocol, revealed by vanishing effective waiting times. Similar effects are reported for the D=3$site-diluted ferromagnetic Ising model (without chaos). However, rejuvenation is reduced if off-equilibrium corrections to the fluctuation-dissipation theorem are considered. Memory and rejuvenation are quantitatively describable in terms of the growth regime of the spin-glass coherence length.
The phase diagram of the simplest approximation to Double-Exchange systems, the bosonic Double-Exchange model with antiferromagnetic super-exchange coupling, is fully worked out by means of Monte Carlo simulations, large-N expansions and Variational Mean-Field calculations. We find a rich phase diagram, with no first-order phase transitions. The most surprising finding is the existence of a segment like ordered phase at low temperature for intermediate AFM coupling which cannot be detected in neutron-scattering experiments. This is signaled by a maximum (a cusp) in the specific heat. Below the phase-transition, only short-range ordering would be found in neutron-scattering. Researchers looking for a Quantum Critical Point in manganites should be wary of this possibility. Finite-Size Scaling estimates of critical exponents are presented, although large scaling corrections are present in the reachable lattice sizes.
The SUE machine is used to extend by a factor of 1000 the time-scale of previous studies of the aging, out-of-equilibrium dynamics of the Edwards-Anderson model with binary couplings, on large lattices (L=60). The correlation function, $C(t+t_w,t_w)$, $t_w$ being the time elapsed under a quench from high-temperature, follows nicely a slightly-modified power law for $t>t_w$. Very tiny (logarithmic), yet clearly detectable deviations from the full-aging $t/t_w$ scaling can be observed. Furthermore, the $t<t_w$ data shows clear indications of the presence of more than one time-sector in the aging dynamics. Similar results are found in four-dimensions, but a rather different behaviour is obtained in the infinite-dimensional $z=6$ Viana-Bray model. Most surprisingly, our results in infinite dimensions seem incompatible with dynamical ultrametricity. A detailed study of the link correlation function is presented, suggesting that its aging-properties are the same as for the spin correlation-function.
We study the fluctuation-dissipation relations for a three dimensional Ising spin glass in a magnetic field both in the high temperature phase as well as in the low temperature one. In the region of times simulated we have found that our results support a picture of the low temperature phase with broken replica symmetry, but a droplet behavior can not be completely excluded.
The physical origin of the backbendings in the equations of state of finite but not necessarily small systems is studied in the Ising model with fixed magnetization (IMFM) by means of the topological properties of the observable distributions and the analysis of the largest cluster with increasing lattice size. Looking at the convexity anomalies of the IMFM thermodynamic potential, it is shown that the order of the transition at the thermodynamic limit can be recognized in finite systems independently of the lattice size. General statistical mechanics arguments and analytical calculations suggest that the backbending in the caloric curve is a transient behaviour which should not converge to a plateau in the thermodynamic limit, while the first order transition is signalled by a discontinuity in other observables.
It is shown that a bosonic formulation of the double-exchange model, one of the classical models for magnetism, generates dynamically a gauge-invariant phase in a finite region of the phase diagram. We use analytical methods, Monte Carlo simulations and Finite-Size Scaling analysis. We study the transition line between that region and the paramagnetic phase. The numerical results show that this transition line belongs to the Universality Class of the Antiferromagnetic RP(2) model. The fact that one can define a Universality Class for the Antiferromagnetic RP(2) model, different from the one of the O(N) models, is puzzling and somehow contradicts naive expectations about Universality.