arXiv subjects

S. K. Basu

Publications and source records attributed to S. K. Basu.

16 recordsLinked to original sources

arXiv2019

Modeling Tumor Angiogenesis with Cellular Automata

Angiogenesis is the formation of new blood vessels from the existing vessels. During tumour angiogenesis, tumour cells secret a number of chemical substrates called tumour angiogenic factors (TAFs). These factors diffuse through the extracellular matrix (ECM) and degrade the basement membrane of nearby vasculature. The TAFs also disrupt the corresponding endothelial cell receptors and form finger like capillary sprouts. These factors also create a chemical gradient (chemotaxis) between the tumour and the surrounding blood vessels. Due to the chemotactic force, the capillary sprouts migrate towards the tumour. On the other hand, a haptotactic force generated due to fibronectin which is secreted by the endothelial cell, also acts on these sprouts. These sprouts grow through the proliferation of recruited endothelial cells from the parent vessels. Tumour angiogenesis is not fully understood yet. In this paper, we use 2-D cellular automata (CA) model to study the behavior of tumour angiogenesis using both Moore and von-Neumann neighborhood. The CA model also mimics capillary sprout branching and the fusion of two adjacent sprout tips (anastomoses). In this simulation, a couple of important points are noted: a) no two capillary sprouts are generated from adjacent locations; b) as the sprouts approach closer to the tumour, its branching tendency increases; c) chemotaxis is the most effective driving force for angiogenesis.

q-bio.TO↗

arXiv2019

Lattice-Based Fuzzy Medical Expert System for Low Back Pain Management

Low Back Pain (LBP) is a common medical condition that deprives many individuals worldwide of their normal routine activities. In the absence of external biomarkers, diagnosis of LBP is quite challenging. It requires dealing with several clinical variables, which have no precisely quantified values. Aiming at the development of a fuzzy medical expert system for LBP management, this research proposes an attractive lattice-based knowledge representation scheme for handling imprecision in knowledge, offering a suitable design methodology for a fuzzy knowledge base and a fuzzy inference system. The fuzzy knowledge base is constructed in modular fashion, with each module capturing interrelated medical knowledge about the relevant clinical history, clinical examinations and laboratory investigation results. This approach in design ensures optimality, consistency and preciseness in the knowledge base and scalability. The fuzzy inference system, which uses the Mamdani method, adopts the triangular membership function for fuzzification and the Centroid of Area technique for defuzzification. A prototype of this system has been built using the knowledge extracted from the domain expert physicians. The inference of the system against a few available patient records at the ESI Hospital, Sealdah has been checked. It was found to be acceptable by the verifying medical experts.

cs.AI↗

arXiv2019

Tumour Induced Angiogenesis and Its Simulation

Due to over-metabolism, the tumour cells become hypoxic. To overcome this situation tumour cells secret several chemical substrates to attract nearby blood vessels towards it (angiogenesis). Transition from avascular to vascular tumour is possible with the initiation of angiogenesis. Angiogenesis also plays a crucial role to spread the cancer cells and its colonization at the distant locations of the body (metastasis). In this paper, we briefly review the processes and factors which directly affect tumour angiogenesis or may get affected by it. A model based on cellular automata is developed to demonstrate this complex process through MATLAB based simulation.

physics.bio-ph↗

arXiv2019

Anomalous Advection-Diffusion Models for Avascular Tumour Growth

In this study, we model avascular tumour growth in epithelial tissue. This can help us to get a macroscopic view of the interaction between the tumour with its surrounding microenvironment and the physical changes within the tumour spheroid. This understanding is likely to assist in the development of better diagnostics, improved therapies and prognostics. In biological systems, most of the diffusive and convective processes are through cellular membranes which are porous in nature. Due to its porous nature, diffusive processes in biological systems are heterogeneous. Fractional advection-diffusion equations are well suited to model heterogeneous biological systems; though most of the early studies did not use this fact. They modelled tumour growth with simple advection-diffusion equation or diffusion equation. We have developed two spherical models based on fractional advection-diffusion equations: one of fixed order and the other of variable order for avascular tumour. These two models are investigated from phenomenological view by measuring some parameters for characterizing avascular tumour growth over time. It is found that both the models offer realistic and insightful information for tumour growth at the macroscopic level, and approximate well the physical phenomena. The fixed-order model always overestimates clinical data like tumour radius, and tumour volume. The cell counts in both the models lie in the clinically established range. As the simulation parameters get modified due to different biochemical and biophysical processes, the robustness of the model is determined. It is found that, the sensitivity of the fixed-order model is low while the variable-order model is moderately sensitive to the parameters.

q-bio.TO↗

arXiv2016

Shape coexistence in 153Ho

The high-spin states in 153Ho, have been studied by 139 57 La(20Ne, 6n) reaction at a projectile energy of 139 MeV at Variable Energy Cyclotron Centre (VECC), Kolkata, India, utilizing an earlier campaign of Indian National Gamma Array (INGA) setup. Data from gamma-gamma coincidence, directional correlation and polarization measurements have been analyzed to assign and confirm the spins and parities of the levels. We have suggested a few additions and revisions of the reported level scheme of 153Ho. The RF-gamma time difference spectra have been useful to confirm the half-life of an isomer in this nucleus. From the comparison of experimental and theoretical results, it is found that there are definite indications of shape coexistence in this nucleus. The experimental and calculated lifetimes of several isomers have been compared to follow the coexistence and evolution of shape with increasing spin.

nucl-ex↗

arXiv2014

Crossing of large multiquasiparticle magnetic-rotation bands in $^{198}$Bi

High-spin states in the doubly-odd $^{198}$Bi nucleus have been studied by using the $^{185,187}$Re($^{16}$O, xn) reactions at the beam energy of 112.5 MeV. $γ-γ$ coincidence were measured by using the INGA array with 15 Compton suppressed clover HPGe detectors. The observed levels have been assigned definite spin-parity. The high spin structure is grouped into three bands (B1, B2 and B3), of which two (B1 and B2) exhibit the properties of magnetic rotation (MR). Tilted axis cranking calculations were carried out to explain the MR bands having large multi-quasiparticle configurations. The calculated results explain the bands B1 and B2 very nicely, confirming the shears mechanism and suggest a crossing of two MR bands in both the cases. The crossing is from 6-qp to 8-qp in band B1 and from 4-qp to 6-qp in band B2, a very rare finding. A semiclassical model has also been used to obtain the particle-hole interaction strengths for the bands B1 and B2, below the band crossing.

nucl-ex↗

arXiv2013

Linear Polarization Measurements for High-Spin States in 146Gd

A γ-ray linear polarization measurement has been performed to directly determine the parities for the levels in 146Gd nucleus. High-spin states in this nucleus were populated in a reaction 115In + 34S at 140 MeV incident energy. Linearly polarized γ - rays emitted from oriented states were measured using a Compton polarimeter consisting of an array of 8 Compton-suppressed Clover detectors. Unambiguous assignments of the spin and parity have been made for most of the observed levels and changes made in the previously reported spin-parity assignments for a few levels. Shell model calculations performed with judicious truncation over the π(gdsh) valence space interpret the structure of only the low-lying levels up to Jπ = 19+ and 9-. N = 82 neutron-core breaking is found to be essential for high spin states with excitation energies Ex > 7 MeV.

nucl-ex↗

arXiv2012

Onset of deformation at $N = 112$ in Bi nuclei

The high spin states in $^{195}$Bi has been studied by $γ$-ray spectroscopic method using the $^{181}$Ta($^{20}$Ne, 6n) fusion evaporation reaction at 130 MeV. The $γγ$ coincidence data were taken using an array of 8 clover HPGe detectors. The spin and parity assignments of the excited states have been made from the measured directional correlation from oriented states (DCO) ratios and integrated polarization asymmetry (IPDCO) ratios. The results show, for the first time, the evidence of a rotational like band based on a 13/2$^+$ band head in this nucleus, indicating the onset of deformation at neutron number $N = 112$ for the Bismuth isotopes. The results obtained were found to be consistent with the prediction of the total Routhian surface calculations using Woods Saxon potential. The same calculations also predict a change in shape from oblate to triaxial in $^{195}$Bi at high rotational frequency.

nucl-ex↗

arXiv2007

Characterization of fragment emission in ^{20}Ne (7 - 10 MeV/nucleon) + ^{12}C reactions

The inclusive energy distributions of the complex fragments (3 $\leq$ Z $\leq$ 7) emitted from the bombardment of ^{12}C by ^{20}Ne beams with incident energies between 145 and 200 MeV have been measured in the angular range 10$^{o} \leq θ_{lab} \leq$ 50^{o}. Damped fragment yields in all the cases have been found to be the characteristic of emission from fully energy equilibrated composites. The binary fragment yields are compared with the standard statistical model predictions. Enhanced yields of entrance channel fragments (5 $\leq$ Z $\leq$ 7) indicate the survival of orbiting-like process in ^{20}Ne + ^{12}C system at these energies.

nucl-ex↗

arXiv2006

Influence of projectile - breakup threshold on complete fusion

Complete fusion excitations for 11,10B+159Tb have been measured at energies around the respective Coulomb barriers, and the existing complete fusion measurements for 7Li+159Tb have been extended to higher energies. The measurements show significant reduction of complete fusion cross sections at above-barrier energies for both the reactions, 10B+159Tb and 7Li+159Tb, when compared to those for 11B+159Tb. The comparison shows that the extent of suppression of complete fusion cross sections is correlated with the -separation energies of the projectiles. Also, the two reactions, 10B+159Tb and 7Li+159Tb were found to produce incomplete fusion products at energies near the respective Coulomb barriers, with the - particle emitting channel being the favoured incomplete fusion process in both the cases.

nucl-ex↗

arXiv2005

Survival of orbiting in $^{20}$Ne (7 - 10 MeV/nucleon) + $^{12}$C reactions

The inclusive energy distributions of fragments with Z $\geq$ 3 emitted from the bombardment of $^{12}$C by $^{20}$Ne beams with incident energies between 145 and 200 MeV have been measured in the angular range $θ_{lab} \sim$ 10$^\circ$ - 50$^\circ$. Damped fragment yields in all cases have been found to be characteristic of emission from fully energy equilibrated composites; for B, C fragments, average Q-values, $ $, were independent of the centre of mass emission angle ($θ_{c.m}$), and the angular distributions followed $\sim$1/sin$θ_{c.m}$ like variation, signifying long life times of the emitting di-nuclear systems. Total yields of these fragments have been found to be much larger compared to the standard statistical model predictions of the same. This may be indicative of the survival of orbiting like process in $^{12}$C + $^{20}$Ne system at these energies.

nucl-ex↗

arXiv2004

Dissipation of angular momentum in light heavy ion collision

The inclusive energy distributions of fragments (4$\leq$Z$\leq$7) emitted in the reactions $^{16}$O (116 MeV) + $^{27}$Al, $^{28}$Si, $^{20}$Ne (145 MeV) + $^{27}$Al, $^{59}$Co have been measured in the angular range $θ_{lab} $= 10$^\circ$ - 65$^\circ$. Fusion-fission and deep inelastic components of the fragment emission have been extracted from the experimental data. The angular mometum dissipations in fully damped deep inelastic collisions have been estimated assming exit channel configuration similar to those for fusion-fission process. It has been found that, the angular momentum dissipations are more than those predicted by the empirical sticking limit in all cases. The deviation is found to increase with increasing charge transfer (lighter fragments). Qualitatively, this may be due to stronger friction in the exit channel. Moreover, for the heavier system $^{20}$Ne + $^{59}$Co, the overall magnitude of deviation is less as compared to those for the lighter systems, {\it i.e.}, $^{16}$O + $^{27}$Al, $^{28}$Si, $^{20}$Ne + $^{27}$Al. This may be due to lesser overlap in time scales of fusion and deep inelastic time scales for heavier systems.

nucl-ex↗

arXiv2002

Dissipative collisions in $^{16}$O + $^{27}$Al at E$_{lab}$=116 MeV

The inclusive energy distributions of fragments (3$\leq$Z$\leq$7) emitted in the reaction $^{16}$O + $^{27}$Al at $E_{lab} = $116 MeV have been measured in the angular range $θ_{lab} $= 15$^\circ$ - 115$^\circ$. A non-linear optimisation procedure using multiple Gaussian distribution functions has been proposed to extract the fusion-fission and deep inelastic components of the fragment emission from the experimental data. The angular distributions of the fragments, thus obtained, from the deep inelastic component are found to fall off faster than those from the fusion-fission component, indicating shorter life times of the emitting di-nuclear systems. The life times of the intermediate di-nuclear configurations have been estimated using a diffractive Regge-pole model. The life times thus extracted ($\sim 1 - 5\times 10^{-22}$ Sec.) are found to decrease with the increase in the fragment charge. Optimum Q-values are also found to increase with increasing charge transfer i.e. with the decrease in fragment charge.

nucl-ex↗

arXiv2002

Light charged particle evaporation from hot ${31}^$P nucleus at E$^*$ ~ 60 MeV

The energy spectra of evaporated light charged particles (LCP) $α$, p, d and t have been measured in $7^$Li(47 MeV) + ${24}^$Mg and ${19}^$F(96 MeV)+ ${12}^$C reactions. Both the systems populate the same compound nucleus ${31}^$F at excitation energy E$^*$ ~ 60 MeV. It has been observed that the light particle spectra obtained in Li + Mg reaction follow standard statistical model prediction, whereas a deformed configuration of the compound nucleus is needed to explain the LCP spectra for F + C reaction, which has been attributed to the effect of larger input angular momentum in the case of ${19}^$F(96 MeV)+ ${12}^$C system.

nucl-ex↗

arXiv2001

Exclusive light particle measurements for the system $^{19}$F + $^{12}$C at 96 MeV

Decay sequence of hot ${31}^$P nucleus has been investigated through exclusive light charged particle measurements in coincidence with individual evaporation residues using the reaction ${19}^$F (96 MeV) + ${12}^$C. Information on the sequential decay chain have been extracted by confronting the data with the predictions of the statistical model. It is observed from the present analysis that such exclusive light charged particle data may be used as a powerful tool to probe the decay sequence of the hot light compound systems.

nucl-ex↗

arXiv1998

Evaporation of alpha particles from $^31$P nucleus

The energy spectra of alpha particles have been measured in coincidence with the evaporation residues for the decay of the compound nucleus $^31$P produced in the reaction $^19$F (96 MeV) + $^12$C. The data have been compared with the predictions of the statistical model code CASCADE. It has been observed that significant deformation effect in the compound nucleus need to be considered in order to explain the shape of the evaporated alpha particle energy spectra.

nucl-ex↗