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S. M. Goetz

Publications and source records attributed to S. M. Goetz.

2 recordsLinked to original sources

Coil-Integrated Alignment Sensor for Real-Time Feedback of Coil-Scalp Contact Point and Angle During Transcranial Magnetic Stimulation (TMS)

Whereas coil positioning in transcranial magnetic stimulation (TMS) to reach a specific cortical target with modern focal stimulation coils has been intensively studied, the alignment and contact of a coil with the head is often ignored. Focal figure-of-eight coils have a point on the surface, where they generate the largest induced electric field. This point should touch the head first, and the coil should be approximately tangential to the head in this point. Previous research has demonstrated the large impact if the coil does not touch the head with the right point and that many operators struggle with establishing or maintaining the correct coil-scalp alignment. This paper presents a technological support technology that can monitor the exact position of the contact point and also pressure to provide feedback to users. As the system uses exclusively components from consumer electronics, the sensor is low-cost and affordable. Through proper design, we achieved sufficient robustness so that the sensor does neither reset during TMS pulses and also not show any detectable degradation.

physics.med-ph

Modular Pulse Synthesizer for Transcranial Magnetic Stimulation with Flexible User-Defined Pulse Shaping and Rapidly Changing Pulses in Sequences

The temporal shape of a pulse in transcranial magnetic stimulation (TMS) influences which neuron populations are activated preferentially as well as the strength and even direction of neuromodulation effects. Furthermore, various pulse shapes differ in their efficiency, coil heating, sensory perception, and clicking sound. However, the available TMS pulse shape repertoire is still very limited to a few pulses with sinusoidal or near-rectangular shapes. Monophasic pulses, though found to be more selective and stronger in neuromodulation, are generated inefficiently and therefore only available in simple low-frequency repetitive protocols. Despite a strong interest to exploit the temporal effects of TMS pulse shapes and pulse sequences, waveform control is relatively inflexible and only possible parametrically within certain limits. Previously proposed approaches for flexible pulse shape control, such as through power electronic inverters, have significant limitations: Existing semiconductor switches can fail under the immense electrical stress associated with free pulse shaping, and most conventional power inverter topologies are incapable of generating smooth electric fields or existing pulse shapes. Leveraging intensive preliminary work on modular power electronics, we present a modular pulse synthesizer (MPS) technology that can, for the first time, flexibly generate high-power TMS pulses with user-defined electric field shape as well as rapid sequences of pulses with high output quality. The circuit topology breaks the problem of simultaneous high power and switching speed into smaller, manageable portions. MPS TMS can synthesize practically any pulse shape, including conventional ones, with fine quantization of the induced electric field.

physics.med-ph