arXiv subjects

S. Muraro

Publications and source records attributed to S. Muraro.

10 recordsLinked to original sources

arXiv2026

Toward High-Resolution Detection of Target Fragmentation: TEA-Sensitized NIT for Proton Therapy Applications

Nano Imaging Trackers (NIT) are fine-grained nuclear emulsions capable of tracking charged particles with sub-micrometric spatial resolution. The DAMON (Direct Measurement of Target Fragmentation) experiment recently employed NIT to detect target-fragmentation events relevant to proton therapy in direct kinematics. These measurements showed that the small crystal size, while providing high spatial resolution, limits the reconstruction efficiency for primary proton tracks and high-energy secondary protons. This work reports an enhancement of NIT sensitivity achieved through alternative chemical sensitization methods, namely gold-plus-sulfur (Au-S) and triethanolamine (TEA), together with the use of the GR-1 developer. The detector response was evaluated with gamma-ray, carbon-ion and proton exposures, including clinically relevant proton energies.

physics.ins-det↗

arXiv2025

Cross Section Measurements of Large Angle Fragments Production in the Interaction of Carbon Ion Beams with Thin Targets

The fragmentation cross sections of carbon ion beams with kinetic energies of $115 - 353~\text{MeV/u}$ impinging on thin targets of graphite (C), polyvinyl-toluene (C$_9$H$_{10}$) and PMMA (C$_2$O$_5$H$_8$) have been measured at 90$^{\text{o}}$ and 60$^{\text{o}}$ at the CNAO particle therapy center (Pavia, Italy). The presented measurements are a complete reanalysis by the FOOT collaboration of already published elemental cross section on composite targets, in order to refine the analysis, improve the systematic uncertainties and show the comparison with the FLUKA Monte Carlo code calculations. In this work, the kinetic energy at production of measured fragments has been completely redefined, together with the efficiencies computation. The new analysis strategy has been successfully validated against the Monte Carlo cross sections. Two detection arms were positioned at two different angles to perform the measurement at 90$^{\text{o}}$ and 60$^{\text{o}}$. The fragment species have been identified in charge (Z$_{id}$ = H) and mass (M$_{id}$ = $^1$H, $^2$H, $^3$H) combining the information of the deposited energy in thin plastic scintillators, of the deposited energy in a thick LYSO crystal and of the fragments Time of Flight (ToF) measurement. The ToF was also used to compute the fragments measured kinetic energy. The cross sections are presented as a function of the fragments kinetic energy at production thanks to an unfolding technique applied to the data.

nucl-ex↗

arXiv2024

Angular differential and elemental fragmentation cross sections of a $400\,\text{MeV/nucleon}$ $^{16}\text{O}$ beam on a graphite target with the FOOT experiment

This paper presents the measurements of the angular differential cross sections for the forward production of He, Li, Be, B, C and N nuclei in the fragmentation process of a 400$\text{MeV/nucleon}$ $^{16}\text{O}$ beam interacting with a graphite target. Due to the limited data available in this energy regime, these measurements of nuclear fragmentation cross sections are relevant to improve nuclear interaction models for Particle Therapy and space radioprotection applications. The data analyzed in this paper were collected during a measurement campaign carried out at the GSI Helmholtz Center for Heavy Ion Research facility in Darmstadt (Germany) by the FOOT collaboration. The results are compared with similar results found in the literature and with a previous FOOT measurement of the same process, using the same setup, from a previous pilot run performed at GSI. The pilot run data, however, had limited statistics and only allowed for the measurement of elemental fragmentation cross sections integrated in the setup acceptance. This data set, with statistics more than 100 times larger compared to the data collected in the previous run, enabled the measurement of angular differential cross sections, fully exploiting the granularity of the FOOT $\Delta \text{E}$-TOF system. Furthermore, a better comprehension of the FOOT apparatus allowed to improve the analysis techniques, leading to a reduction in the final systematic uncertainties.

nucl-ex↗

arXiv2018

Analysis of time-profiles with in-beam PET monitoring in charged particle therapy

Background: Treatment verification with PET imaging in charged particle therapy is conventionally done by comparing measurements of spatial distributions with Monte Carlo (MC) predictions. However, decay curves can provide additional independent information about the treatment and the irradiated tissue. Most studies performed so far focus on long time intervals. Here we investigate the reliability of MC predictions of space and time (decay rate) profiles shortly after irradiation, and we show how the decay rates can give an indication about the elements of which the phantom is made up. Methods and Materials: Various phantoms were irradiated in clinical and near-clinical conditions at the Cyclotron Centre of the Bronowice proton therapy centre. PET data were acquired with a planar 16x16 cm$^2$ PET system. MC simulations of particle interactions and photon propagation in the phantoms were performed using the FLUKA code. The analysis included a comparison between experimental data and MC simulations of space and time profiles, as well as a fitting procedure to obtain the various isotope contributions in the phantoms. Results and conclusions: There was a good agreement between data and MC predictions in 1-dimensional space and decay rate distributions. The fractions of $^{11}$C, $^{15}$O and $^{10}$C that were obtained by fitting the decay rates with multiple simple exponentials generally agreed well with the MC expectations. We found a small excess of $^{10}$C in data compared to what was predicted in MC, which was clear especially in the PE phantom.

physics.med-ph↗

arXiv2016

Secondary radiation measurements for particle therapy applications: nuclear fragmentation produced by $^4$He ion beams in a PMMA target

Nowadays there is a growing interest in Particle Therapy treatments exploiting light ion beams against tumors due to their enhanced Relative Biological Effectiveness and high space selectivity. In particular promising results are obtained by the use of $^4$He projectiles. Unlike the treatments performed using protons, the beam ions can undergo a fragmentation process when interacting with the atomic nuclei in the patient body. In this paper the results of measurements performed at the Heidelberg Ion-Beam Therapy center are reported. For the first time the absolute fluxes and the energy spectra of the fragments - protons, deuterons, and tritons - produced by $^4$He ion beams of 102, 125 and 145 MeV/u energies on a poly-methyl methacrylate target were evaluated at different angles. The obtained results are particularly relevant in view of the necessary optimization and review of the Treatment Planning Software being developed for clinical use of $^4$He beams in clinical routine and the relative benchmarking of Monte Carlo algorithm predictions.

physics.med-ph↗

arXiv2016

Secondary radiation measurements for particle therapy applications: Charged secondaries produced by 4He and 12C ion beams in a PMMA target at large angle

Measurements performed with the purpose of characterizing the charged secondary radiation for dose release monitoring in particle therapy are reported. Charged secondary yields, energy spectra and emission profiles produced in poly-methyl methacrylate (PMMA) target by 4He and 12C beams of different therapeutic energies were measured at 60 and 90 degree with respect to the primary beam direction. The secondary yields of protons produced along the primary beam path in PMMA target were obtained. The energy spectra of charged secondaries were obtained from time-of-flight information, whereas the emission profiles were reconstructed exploiting tracking detector information. The measured charged secondary yields and emission profiles are in agreement with the results reported in literature and confirm the feasibility of ion beam therapy range monitoring using 12C ion beam. The feasibility of range monitoring using charged secondary particles is also suggested for 4He ion beam.

physics.med-ph↗

arXiv2012

Charged particle's flux measurement from PMMA irradiated by 80 MeV/u carbon ion beam

Hadrontherapy is an emerging technique in cancer therapy that uses beams of charged particles. To meet the improved capability of hadrontherapy in matching the dose release with the cancer position, new dose monitoring techniques need to be developed and introduced into clinical use. The measurement of the fluxes of the secondary particles produced by the hadron beam is of fundamental importance in the design of any dose monitoring device and is eagerly needed to tune Monte Carlo simulations. We report the measurements done with charged secondary particles produced from the interaction of a 80 MeV/u fully stripped carbon ion beam at the INFN Laboratori Nazionali del Sud, Catania, with a Poly-methyl methacrylate target. Charged secondary particles, produced at 90$\degree$ with respect to the beam axis, have been tracked with a drift chamber, while their energy and time of flight has been measured by means of a LYSO scintillator. Secondary protons have been identified exploiting the energy and time of flight information, and their emission region has been reconstructed backtracking from the drift chamber to the target. Moreover a position scan of the target indicates that the reconstructed emission region follows the movement of the expected Bragg peak position. Exploting the reconstruction of the emission region, an accuracy on the Bragg peak determination in the submillimeter range has been obtained. The measured differential production rate for protons produced with $E^{\rm Prod}_{\rm kin} >$ 83 MeV and emitted at 90$\degree$ with respect to the beam line is: $dN_{\rm P}/(dN_{\rm C}dΩ)(E^{\rm Prod}_{\rm kin} > 83 {\rm ~MeV}, θ=90\degree)= (2.69\pm 0.08_{\rm stat} \pm 0.12_{\rm sys})\times 10^{-4} sr^{-1}$.

physics.med-ph↗

arXiv2011

Underground operation of the ICARUS T600 LAr-TPC: first results

Open questions are still present in fundamental Physics and Cosmology, like the nature of Dark Matter, the matter-antimatter asymmetry and the validity of the particle interaction Standard Model. Addressing these questions requires a new generation of massive particle detectors exploring the subatomic and astrophysical worlds. ICARUS T600 is the first large mass (760 ton) example of a novel detector generation able to combine the imaging capabilities of the old famous "bubble chamber" with an excellent energy measurement in huge electronic detectors. ICARUS T600 now operates at the Gran Sasso underground laboratory, studying cosmic rays, neutrino oscillation and proton decay. Physical potentialities of this novel telescope are presented through few examples of neutrino interactions reconstructed with unprecedented details. Detector design and early operation are also reported.

hep-ex↗

arXiv2007

Secondary Cosmic Ray particles due to GCR interactions in the Earth's atmosphere

Primary GCR interact with the Earth's atmosphere originating atmospheric showers, thus giving rise to fluxes of secondary particles in the atmosphere. Electromagnetic and hadronic interactions interplay in the production of these particles, whose detection is performed by means of complementary techniques in different energy ranges and at different depths in the atmosphere, down to the Earth's surface. Monte Carlo codes are essential calculation tools which can describe the complexity of the physics of these phenomena, thus allowing the analysis of experimental data. However, these codes are affected by important uncertainties, concerning, in particular, hadronic physics at high energy. In this paper we shall report some results concerning inclusive particle fluxes and atmospheric shower properties as obtained using the FLUKA transport and interaction code. Some emphasis will also be given to the validation of the physics models of FLUKA involved in these calculations.

astro-ph↗

arXiv2006

The hadronic models for cosmic ray physics: the FLUKA code solutions

FLUKA is a general purpose Monte Carlo transport and interaction code used for fundamental physics and for a wide range of applications. These include Cosmic Ray Physics (muons, neutrinos, EAS, underground physics), both for basic research and applied studies in space and atmospheric flight dosimetry and radiation damage. A review of the hadronic models available in FLUKA and relevant for the description of cosmic ray air showers is presented in this paper. Recent updates concerning these models are discussed. The FLUKA capabilities in the simulation of the formation and propagation of EM and hadronic showers in the Earth's atmosphere are shown.

hep-ph↗