arXiv subjects

Sagar Kamarthi

Publications and source records attributed to Sagar Kamarthi.

12 recordsLinked to original sources

arXiv2026

REFINEPPO: Learning Continuous Control Policies by Iterative Action Refinement

Deep reinforcement learning (DRL) has achieved strong performance across a wide range of continuous-control problems. These continuous-control policies, however, are often defined as direct mappings from an observed state to an action or action distribution, requiring a single feed-forward network to construct an optimal control decision in one pass. While effective, this formulation leaves little opportunity for the policy to reconsider or progressively improve an action once an initial prediction has been formed. In this work, we explore an alternative approach: rather than learning only to directly predict an action, can a policy learn to iteratively improve one, and can this iterative process provide advantages during policy learning? We introduce Iterative Action Refinement (IAR), an iterative action-construction method that constructs control actions through a sequence of learned residual corrections. Starting from an initial proposal, a shared refinement network repeatedly conditions on the observed state and the current action proposal, allowing each refinement step to revise the action constructed by preceding steps. The final refined proposal is then used to determine the action executed by the agent. We integrate this iterative action-construction mechanism with Proximal Policy Optimization (PPO), yielding REFINEPPO. We evaluate REFINEPPO across 14 benchmark control tasks, complemented by controlled ablations of refinement depth and update schedules and analyses aimed at understanding why iterative refinement is effective. Across these environments, REFINEPPO matches or exceeds the performance of standard PPO while demonstrating faster convergence on several tasks.

cs.LG↗

arXiv2026

Conditional Cognitive Biases in LLMs: How Biased User Turns Modulate In-Context Reasoning

We present an evaluation of cognitive bias expression in state-of-the-art instruction-tuned LLMs under realistic multi-turn interaction settings. Our work introduces a novel three-condition experimental framework that disentangles the effect of exposure to a biased user turn from the effect of the turn's semantic content, alongside a benchmark of 24,300 jury-validated user prompts spanning all 81 cells of a 9x9 target-human bias interaction matrix. Across eight frontier LLMs, we find that biased conversational context systematically increases bias expression relative to zero-shot baselines in 6 of 8 models. We identify two competing behavioral dynamics underlying this effect: conversational exposure to biased reasoning generally amplifies downstream bias tendencies, while explicitly stated bias cues often trigger alignment-related suppression behaviors that reduce overt bias expression. We release our framework, codebase, and dataset to support future research on context-conditioned cognitive biases and behavioral adaptation in LLMs.

cs.CL↗

arXiv2026

Prototype Guided Post-pretraining for Single-Cell Representation Learning

Single-cell representation learning (SCRL) from gene expression data offers a way to uncover the complex regulatory logic underlying cellular function. Inspired by large language models in natural language modeling, several single-cell pretrained models have recently been proposed that treat genes as tokens and cells as sentences. However, these models are fundamentally limited by the long-tailed nature of cell-type distributions and struggle to generalize under covariate shifts in gene expression data. While fine-tuning is often used to mitigate these issues, we observe that performance remains bounded. To address this challenge, we introduce CellRefine, a post-pretraining method that operates between the pretraining and fine-tuning stages of a single-cell foundation model. CellRefine uses a multi-faceted objective that incorporates marker-gene sets as structural priors to guide post-pretraining and refine the latent embedding manifold of cells. Across multiple computational biology tasks, empirical results show that CellRefine consistently improves downstream performance, yielding gains up to 15%.

cs.LG↗

arXiv2026

Temporal Data Requirement for Predicting Unplanned Hospital Readmissions

With the proliferation of Electronic Health Records (EHRs), a critical challenge in building predictive models is determining the optimal historical data time window to maximize accuracy. This study investigates the impact of various observation windows ranging from the day of surgery to three years prior on predicting 30-day readmission following hip and knee arthroplasties. The dataset encompasses both structured encounter records (over 4 million) and unstructured clinical notes (80,000) from 7,174 patients. To extract meaning from the clinical notes, we employed a suite of non neural (BOW, count BOW, TF IDF, LDA) and neural encoders (BERT, 1D CNN, BiLSTM, Average). We subsequently evaluated models utilizing clinical notes alone, structured data alone, and a combination of both modalities. Our results demonstrate that the optimal time window for unstructured clinical notes is significantly shorter than for structured data, maximum predictive performance was achieved using notes from just three to six months prior to surgery. In contrast, performance using structured data improved as the time window lengthened, but strictly plateaued after twelve months. These modality-specific temporal patterns remained consistent regardless of model complexity or encoder type. Ultimately, these findings challenge the general assumption that more historical data inherently yields better machine learning predictions, establishing targeted time-window guidelines for optimizing readmission prediction models.

cs.LG↗

arXiv2025

Prediction of Clinical Complication Onset using Neural Point Processes

Predicting medical events in advance within critical care settings is paramount for patient outcomes and resource management. Utilizing predictive models, healthcare providers can anticipate issues such as cardiac arrest, sepsis, or respiratory failure before they manifest. Recently, there has been a surge in research focusing on forecasting adverse medical event onsets prior to clinical manifestation using machine learning. However, while these models provide temporal prognostic predictions for the occurrence of a specific adverse event of interest within defined time intervals, their interpretability often remains a challenge. In this work, we explore the applicability of neural temporal point processes in the context of adverse event onset prediction, with the aim of explaining clinical pathways and providing interpretable insights. Our experiments span six state-of-the-art neural point processes and six critical care datasets, each focusing on the onset of distinct adverse events. This work represents a novel application class of neural temporal point processes in event prediction.

cs.LG↗

arXiv2024

A Novel Nonlinear Nonparametric Correlation Measurement With A Case Study on Surface Roughness in Finish Turning

Estimating the correlation coefficient has been a daunting work with the increasing complexity of dataset's pattern. One of the problems in manufacturing applications consists of the estimation of a critical process variable during a machining operation from directly measurable process variables. For example, the prediction of surface roughness of a workpiece during finish turning processes. In this paper, we did exhaustive study on the existing popular correlation coefficients: Pearson correlation coefficient, Spearman's rank correlation coefficient, Kendall's Tau correlation coefficient, Fechner correlation coefficient, and Nonlinear correlation coefficient. However, no one of them can capture all the nonlinear and linear correlations. So, we represent a universal non-linear non-parametric correlation measurement, g-correlation coefficient. Unlike other correlation measurements, g-correlation doesn't require assumptions and pick the dominating patterns of the dataset after examining all the major patterns no matter it is linear or nonlinear. Results of testing on both linearly correlated and non-linearly correlated dataset and comparison with the introduced correlation coefficients in literature show that g-correlation is robust on all the linearly correlated dataset and outperforms for some non-linearly correlated dataset. Results of the application of different correlation concepts to surface roughness assessment show that g-correlation has a central role among all standard concepts of correlation.

stat.ME↗

arXiv2024

pyKCN: A Python Tool for Bridging Scientific Knowledge

The study of research trends is pivotal for understanding scientific development on specific topics. Traditionally, this involves keyword analysis within scholarly literature, yet comprehensive tools for such analysis are scarce, especially those capable of parsing large datasets with precision. pyKCN, a Python toolkit, addresses this gap by automating keyword cleaning, extraction and trend analysis from extensive academic corpora. It is equipped with modules for text processing, deduplication, extraction, and advanced keyword co-occurrence and analysis, providing a granular view of research trends. This toolkit stands out by enabling researchers to visualize keyword relationships, thereby identifying seminal works and emerging trends. Its application spans diverse domains, enhancing scholars' capacity to understand developments within their fields. The implications of using pyKCN are significant. It offers an empirical basis for predicting research trends, which can inform funding directions, policy-making, and academic curricula. The code source and details can be found on: https://github.com/zhenyuanlu/pyKCN

cs.DL↗

arXiv2023

Uncertainty Quantification in Neural-Network Based Pain Intensity Estimation

Improper pain management can lead to severe physical or mental consequences, including suffering, and an increased risk of opioid dependency. Assessing the presence and severity of pain is imperative to prevent such outcomes and determine the appropriate intervention. However, the evaluation of pain intensity is challenging because different individuals experience pain differently. To overcome this, researchers have employed machine learning models to evaluate pain intensity objectively. However, these efforts have primarily focused on point estimation of pain, disregarding the inherent uncertainty and variability present in the data and model. Consequently, the point estimates provide only partial information for clinical decision-making. This study presents a neural network-based method for objective pain interval estimation, incorporating uncertainty quantification. This work explores three algorithms: the bootstrap method, lower and upper bound estimation (LossL) optimized by genetic algorithm, and modified lower and upper bound estimation (LossS) optimized by gradient descent algorithm. Our empirical results reveal that LossS outperforms the other two by providing a narrower prediction interval. As LossS outperforms, we assessed its performance in three different scenarios for pain assessment: (1) a generalized approach (single model for the entire population), (2) a personalized approach (separate model for each individual), and (3) a hybrid approach (separate model for each cluster of individuals). Our findings demonstrate the hybrid approach's superior performance, with notable practicality in clinical contexts. It has the potential to be a valuable tool for clinicians, enabling objective pain intensity assessment while taking uncertainty into account. This capability is crucial in facilitating effective pain management and reducing the risks associated with improper treatment.

cs.LG↗

arXiv2023

Automatic pain recognition from Blood Volume Pulse (BVP) signal using machine learning techniques

Physiological responses to pain have received increasing attention among researchers for developing an automated pain recognition sensing system. Though less explored, Blood Volume Pulse (BVP) is one of the candidate physiological measures that could help objective pain assessment. In this study, we applied machine learning techniques on BVP signals to device a non-invasive modality for pain sensing. Thirty-two healthy subjects participated in this study. First, we investigated a novel set of time-domain, frequency-domain and nonlinear dynamics features that could potentially be sensitive to pain. These include 24 features from BVP signals and 20 additional features from Inter-beat Intervals (IBIs) derived from the same BVP signals. Utilizing these features, we built machine learning models for detecting the presence of pain and its intensity. We explored different machine learning models, including Logistic Regression, Random Forest, Support Vector Machines, Adaptive Boosting (AdaBoost) and Extreme Gradient Boosting (XGBoost). Among them, we found that the XGBoost offered the best model performance for both pain classification and pain intensity estimation tasks. The ROC-AUC of the XGBoost model to detect low pain, medium pain and high pain with no pain as the baseline were 80.06 %, 85.81 %, and 90.05 % respectively. Moreover, the XGboost classifier distinguished medium pain from high pain with ROC-AUC of 91%. For the multi-class classification among three pain levels, the XGBoost offered the best performance with an average F1-score of 80.03%. Our results suggest that BVP signal together with machine learning algorithms is a promising physiological measurement for automated pain assessment. This work will have a national impact on accurate pain assessment, effective pain management, reducing drug-seeking behavior among patients, and addressing national opioid crisis.

cs.LG↗

arXiv2023

Transformer Encoder with Multiscale Deep Learning for Pain Classification Using Physiological Signals

Pain is a serious worldwide health problem that affects a vast proportion of the population. For efficient pain management and treatment, accurate classification and evaluation of pain severity are necessary. However, this can be challenging as pain is a subjective sensation-driven experience. Traditional techniques for measuring pain intensity, e.g. self-report scales, are susceptible to bias and unreliable in some instances. Consequently, there is a need for more objective and automatic pain intensity assessment strategies. In this paper, we develop PainAttnNet (PAN), a novel transfomer-encoder deep-learning framework for classifying pain intensities with physiological signals as input. The proposed approach is comprised of three feature extraction architectures: multiscale convolutional networks (MSCN), a squeeze-and-excitation residual network (SEResNet), and a transformer encoder block. On the basis of pain stimuli, MSCN extracts short- and long-window information as well as sequential features. SEResNet highlights relevant extracted features by mapping the interdependencies among features. The third module employs a transformer encoder consisting of three temporal convolutional networks (TCN) with three multi-head attention (MHA) layers to extract temporal dependencies from the features. Using the publicly available BioVid pain dataset, we test the proposed PainAttnNet model and demonstrate that our outcomes outperform state-of-the-art models. These results confirm that our approach can be utilized for automated classification of pain intensity using physiological signals to improve pain management and treatment.

cs.LG↗

arXiv2022

Review and Analysis of Pain Research Literature through Keyword Co-occurrence Networks

Pain is a significant public health problem as the number of individuals with a history of pain globally keeps growing. In response, many synergistic research areas have been coming together to address pain-related issues. This work conducts a review and analysis of a vast body of pain-related literature using the keyword co-occurrence network (KCN) methodology. In this method, a set of KCNs is constructed by treating keywords as nodes and the co-occurrence of keywords as links between the nodes. Since keywords represent the knowledge components of research articles, analysis of KCNs will reveal the knowledge structure and research trends in the literature. This study extracted and analyzed keywords from 264,560 pain-related research articles indexed in IEEE, PubMed, Engineering Village, and Web of Science published between 2002 and 2021. We observed rapid growth in pain literature in the last two decades: the number of articles has grown nearly threefold, and the number of keywords has grown by a factor of 7. We identified emerging and declining research trends in sensors/methods, biomedical, and treatment tracks. We also extracted the most frequently co-occurring keyword pairs and clusters to help researchers recognize the synergies among different pain-related topics.

cs.IR↗

arXiv2019

Learning to Identify Patients at Risk of Uncontrolled Hypertension Using Electronic Health Records Data

Hypertension is a major risk factor for stroke, cardiovascular disease, and end-stage renal disease, and its prevalence is expected to rise dramatically. Effective hypertension management is thus critical. A particular priority is decreasing the incidence of uncontrolled hypertension. Early identification of patients at risk for uncontrolled hypertension would allow targeted use of personalized, proactive treatments. We develop machine learning models (logistic regression and recurrent neural networks) to stratify patients with respect to the risk of exhibiting uncontrolled hypertension within the coming three-month period. We trained and tested models using EHR data from 14,407 and 3,009 patients, respectively. The best model achieved an AUROC of 0.719, outperforming the simple, competitive baseline of relying prediction based on the last BP measure alone (0.634). Perhaps surprisingly, recurrent neural networks did not outperform a simple logistic regression for this task, suggesting that linear models should be included as strong baselines for predictive tasks using EHR

cs.CY↗