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Sameer K. Deshpande

Publications and source records attributed to Sameer K. Deshpande.

At least 19 recordsLinked to original sources

Heterogeneous Treatment Effect Estimation under Noncompliance in the Illinois Workplace Wellness Study with Bayesian Tree Ensembles

Estimating varying treatment effects in randomized trials with noncompliance is inherently challenging since variation comes from two separate sources: variation in the impact itself and variation in the compliance rate. In this setting, existing flexible machine learning methods are sensitive to the weak instruments problem and can yield unstable estimates of heterogeneity when run repeatedly with different initialization or random seeds. Our main methodological contribution is to present a Bayesian Causal Forest model for binary response variables in scenarios with noncompliance. By repeatedly imputing individuals' compliance types, we can flexibly estimate heterogeneous treatment effects among compliers. Simulation studies demonstrate the usefulness of our approach when compliance and treatment effects are heterogeneous. We use this method to detect and analyze heterogeneity in the treatment effects in the Illinois Workplace Wellness Study, which not only features heterogeneous and one-sided compliance but also several binary outcomes of interest. We focus on three outcomes one year after intervention. We confirm a null effect on the presence of a chronic condition, discover meaningful heterogeneity in the impact of the intervention on metabolic parameters though the average effect is null in classical partial effect estimates, and find heterogeneity in the intervention's effect on individuals' perception of management prioritization of health and safety.

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Multivariate Varying-Coefficient BART with Graphical Horseshoe Priors

Modern multivariate regression problems involve several related outcomes whose regression effects are not only nonlinear, heterogeneous, and outcome-specific, but also where the residual dependence among outcomes is scientifically meaningful. Existing multivariate Bayesian tree-based methods typically address only part of this problem: some impose substantial sharing of tree architecture across outcomes, which is overly restrictive when responses depend on distinct predictors or effect modifiers, while others accommodate residual dependence but retain simpler mean structures. This paper develops multiVCBART, a multivariate varying-coefficient Bayesian additive regression tree framework that jointly models flexible outcome-specific coefficient surfaces and a sparse residual precision matrix. Each entry of the coefficient matrix $B(x)$ is represented by an independent BART ensemble, allowing predictor effects to vary nonlinearly with modifiers $x$ across outcomes, while a Graphical Horseshoe prior on the precision matrix $Ω$ captures parsimonious residual conditional dependence. To permit efficient computation, we introduce a sampler that reduces the multivariate Gaussian likelihood to a sequence of scalar pseudo-response updates, decoupling the tree backfitting from the Graphical Horseshoe step. Theoretically, we establish the first posterior contraction rates for a multivariate BART model with jointly estimated residual dependence, proving near-minimax adaptation to underlying smoothness and structural sparsity. Empirically, multiVCBART outperforms existing multivariate tree models and Bayesian SUR competitors on sparse, high-dimensional datasets. Finally, in a re-analysis of the Genomics of Drug Sensitivity in Cancer dataset, our method identifies distinct biomarker signals and recovers a coherent residual pharmacologic network.

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Quantifying the limits of human athletic performance: A Bayesian analysis of elite decathletes

Because the decathlon tests many facets of athleticism, including sprinting, throwing, jumping, and endurance, many consider it to be the ultimate test of athletic ability. On this view, estimating the maximal decathlon score and understanding what it would take to achieve that score provides insight into the upper limits of human athletic potential. To this end, we develop a Bayesian composition model for forecasting how individual decathletes perform in each of the 10 decathlon events of time. Besides capturing potential non-linear temporal trends in performance, our model carefully captures the dependence between performance in an event and all preceding events. Using our model, we can simulate and evaluate the distribution of the maximal possible scores and identify profiles of decathletes who could realistically attain scores approaching this limit.

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High-dimensional regression with outcomes of mixed-type using the multivariate spike-and-slab LASSO

We consider a high-dimensional multi-outcome regression in which $q,$ possibly dependent, binary and continuous outcomes are regressed onto $p$ covariates. We model the observed outcome vector as a partially observed latent realization from a multivariate linear regression model. Our goal is to estimate simultaneously a sparse matrix ($B$) of latent regression coefficients (i.e., partial covariate effects) and a sparse latent residual precision matrix ($Ω$), which induces partial correlations between the observed outcomes. To this end, we specify continuous spike-and-slab priors on all entries of $B$ and off-diagonal elements of $Ω$ and introduce a Monte Carlo Expectation-Conditional Maximization algorithm to compute the maximum a posterior estimate of the model parameters. Under a set of mild assumptions, we derive the posterior contraction rate for our model in the high-dimensional regimes where both $p$ and $q$ diverge with the sample size $n$ and establish a sure screening property, which implies that, as $n$ increases, we can recover all truly non-zero elements of $B$ with probability tending to one. We demonstrate the excellent finite-sample properties of our proposed method, which we call mixed-mSSL, using extensive simulation studies and three applications spanning medicine to ecology.

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Fitting sparse high-dimensional varying-coefficient models with Bayesian regression tree ensembles

By allowing the effects of $p$ covariates in a linear regression model to vary as functions of $R$ additional effect modifiers, varying-coefficient models (VCMs) strike a compelling balance between interpretable-but-rigid parametric models popular in classical statistics and flexible-but-opaque methods popular in machine learning. But in high-dimensional settings where $p$ and/or $R$ exceed the number of observations, existing approaches to fitting VCMs fail to identify which covariates have a non-zero effect and which effect modifiers drive these effects. We propose sparseVCBART, a fully Bayesian model that approximates each coefficient function in a VCM with a regression tree ensemble and encourages sparsity with a global--local shrinkage prior on the regression tree leaf outputs and a hierarchical prior on the splitting probabilities of each tree. We show that the sparseVCBART posterior contracts at a near-minimax optimal rate, automatically adapting to the unknown sparsity structure and smoothness of the true coefficient functions. Compared to existing state-of-the-art methods, sparseVCBART achieved competitive predictive accuracy and substantially narrower and better-calibrated uncertainty intervals, especially for null covariate effects. We use sparseVCBART to investigate how the effects of interpersonal conversations on prejudice could vary according to the political and demographic characteristics of the respondents.

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Scalable piecewise smoothing with BART

Although it is an extremely effective, easy-to-use, and increasingly popular tool for nonparametric regression, the Bayesian Additive Regression Trees (BART) model is limited by the fact that it can only produce discontinuous output. Initial attempts to overcome this limitation were based on regression trees that output Gaussian Processes instead of constants. Unfortunately, implementations of these extensions cannot scale to large datasets. We propose ridgeBART, an extension of BART built with trees that output linear combinations of ridge functions (i.e., a composition of an affine transformation of the inputs and non-linearity); that is, we build a Bayesian ensemble of localized neural networks with a single hidden layer. We develop a new MCMC sampler that updates trees in linear time and establish posterior contraction rates for estimating piecewise anisotropic Hölder functions and nearly minimax-optimal rates for estimating isotropic Hölder functions. We demonstrate ridgeBART's effectiveness on synthetic data and use it to estimate the probability that a professional basketball player makes a shot from any location on the court in a spatially smooth fashion.

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Oblique Bayesian additive regression trees

Current implementations of Bayesian Additive Regression Trees (BART) are based on axis-aligned decision rules that recursively partition the feature space using a single feature at a time. Several authors have demonstrated that oblique trees, whose decision rules are based on linear combinations of features, can sometimes yield better predictions than axis-aligned trees and exhibit excellent theoretical properties. We develop an oblique version of BART that leverages a data-adaptive decision rule prior that recursively partitions the feature space along random hyperplanes. Using several synthetic and real-world benchmark datasets, we systematically compared our oblique BART implementation to axis-aligned BART and other tree ensemble methods, finding that oblique BART was competitive with -- and sometimes much better than -- those methods.

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VCBART: Bayesian trees for varying coefficients

The linear varying coefficient models posits a linear relationship between an outcome and covariates in which the covariate effects are modeled as functions of additional effect modifiers. Despite a long history of study and use in statistics and econometrics, state-of-the-art varying coefficient modeling methods cannot accommodate multivariate effect modifiers without imposing restrictive functional form assumptions or involving computationally intensive hyperparameter tuning. In response, we introduce VCBART, which flexibly estimates the covariate effect in a varying coefficient model using Bayesian Additive Regression Trees. With simple default settings, VCBART outperforms existing varying coefficient methods in terms of covariate effect estimation, uncertainty quantification, and outcome prediction. We illustrate the utility of VCBART with two case studies: one examining how the association between later-life cognition and measures of socioeconomic position vary with respect to age and socio-demographics and another estimating how temporal trends in urban crime vary at the neighborhood level. An R package implementing VCBART is available at https://github.com/skdeshpande91/VCBART

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Moving from Machine Learning to Statistics: the case of Expected Points in American football

Expected points is a value function fundamental to player evaluation and strategic in-game decision-making across sports analytics, particularly in American football. To estimate expected points, football analysts use machine learning tools, which are not equipped to handle certain challenges. They suffer from selection bias, display counter-intuitive artifacts of overfitting, do not quantify uncertainty in point estimates, and do not account for the strong dependence structure of observational football data. These issues are not unique to American football or even sports analytics; they are general problems analysts encounter across various statistical applications, particularly when using machine learning in lieu of traditional statistical models. We explore these issues in detail and devise expected points models that account for them. We also introduce a widely applicable novel methodological approach to mitigate overfitting, using a catalytic prior to smooth our machine learning models.

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flexBART: Flexible Bayesian regression trees with categorical predictors

Most implementations of Bayesian additive regression trees (BART) one-hot encode categorical predictors, replacing each one with several binary indicators, one for every level or category. Regression trees built with these indicators partition the discrete set of categorical levels by repeatedly removing one level at a time. Unfortunately, the vast majority of partitions cannot be built with this strategy, severely limiting BART's ability to partially pool data across groups of levels. Motivated by analyses of baseball data and neighborhood-level crime dynamics, we overcame this limitation by re-implementing BART with regression trees that can assign multiple levels to both branches of a decision tree node. To model spatial data aggregated into small regions, we further proposed a new decision rule prior that creates spatially contiguous regions by deleting a random edge from a random spanning tree of a suitably defined network. Our re-implementation, which is available in the flexBART package, often yields improved out-of-sample predictive performance and scales better to larger datasets than existing implementations of BART.

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Posterior contraction and uncertainty quantification for the multivariate spike-and-slab LASSO

We study the asymptotic properties of Deshpande et al.\ (2019)'s multivariate spike-and-slab LASSO (mSSL) procedure for simultaneous variable and covariance selection in the sparse multivariate linear regression problem. In that problem, $q$ correlated responses are regressed onto $p$ covariates and the mSSL works by placing separate spike-and-slab priors on the entries in the matrix of marginal covariate effects and off-diagonal elements in the upper triangle of the residual precision matrix. Under mild assumptions about these matrices, we establish the posterior contraction rate for the mSSL posterior in the asymptotic regime where both $p$ and $q$ diverge with $n.$ By ``de-biasing'' the corresponding MAP estimates, we obtain confidence intervals for each covariate effect and residual partial correlation. In extensive simulation studies, these intervals displayed close-to-nominal frequentist coverage in finite sample settings but tended to be substantially longer than those obtained using a version of the Bayesian bootstrap that randomly re-weights the prior. We further show that the de-biased intervals for individual covariate effects are asymptotically valid.

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Adolescent sports participation and health in early adulthood: An observational study

We study the impact of teenage sports participation on early-adulthood health using longitudinal data from the National Study of Youth and Religion. We focus on two primary outcomes measured at ages 23--28 -- self-rated health and total score on the PHQ9 Patient Depression Questionnaire -- and control for several potential confounders related to demographics and family socioeconomic status. To probe the possibility that certain types of sports participation may have larger effects on health than others, we conduct a matched observational study at each level within a hierarchy of exposures. Our hierarchy ranges from broadly defined exposures (e.g., participation in any organized after-school activity) to narrow (e.g., participation in collision sports). We deployed an ordered testing approach that exploits the hierarchical relationships between our exposure definitions to perform our analyses while maintaining a fixed family-wise error rate. Compared to teenagers who did not participate in any after-school activities, those who participated in sports had statistically significantly better self-rated and mental health outcomes in early adulthood.

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Estimating sparse direct effects in multivariate regression with the spike-and-slab LASSO

The multivariate regression interpretation of the Gaussian chain graph model simultaneously parametrizes (i) the direct effects of $p$ predictors on $q$ outcomes and (ii) the residual partial covariances between pairs of outcomes. We introduce a new method for fitting sparse Gaussian chain graph models with spike-and-slab LASSO (SSL) priors. We develop an Expectation Conditional Maximization algorithm to obtain sparse estimates of the $p \times q$ matrix of direct effects and the $q \times q$ residual precision matrix. Our algorithm iteratively solves a sequence of penalized maximum likelihood problems with self-adaptive penalties that gradually filter out negligible regression coefficients and partial covariances. Because it adaptively penalizes individual model parameters, our method is seen to outperform fixed-penalty competitors on simulated data. We establish the posterior contraction rate for our model, buttressing our method's excellent empirical performance with strong theoretical guarantees. Using our method, we estimated the direct effects of diet and residence type on the composition of the gut microbiome of elderly adults.

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New directions in algebraic statistics: Three challenges from 2023

In the last quarter of a century, algebraic statistics has established itself as an expanding field which uses multilinear algebra, commutative algebra, computational algebra, geometry, and combinatorics to tackle problems in mathematical statistics. These developments have found applications in a growing number of areas, including biology, neuroscience, economics, and social sciences. Naturally, new connections continue to be made with other areas of mathematics and statistics. This paper outlines three such connections: to statistical models used in educational testing, to a classification problem for a family of nonparametric regression models, and to phase transition phenomena under uniform sampling of contingency tables. We illustrate the motivating problems, each of which is for algebraic statistics a new direction, and demonstrate an enhancement of related methodologies.

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Are you using test log-likelihood correctly?

Test log-likelihood is commonly used to compare different models of the same data or different approximate inference algorithms for fitting the same probabilistic model. We present simple examples demonstrating how comparisons based on test log-likelihood can contradict comparisons according to other objectives. Specifically, our examples show that (i) approximate Bayesian inference algorithms that attain higher test log-likelihoods need not also yield more accurate posterior approximations and (ii) conclusions about forecast accuracy based on test log-likelihood comparisons may not agree with conclusions based on root mean squared error.

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Evaluating plate discipline in Major League Baseball with Bayesian Additive Regression Trees

We introduce a three-step framework to determine at which pitches Major League batters should swing. Unlike traditional plate discipline metrics, which implicitly assume that all batters should always swing at (resp. take) pitches inside (resp. outside) the strike zone, our approach explicitly accounts not only for the players and umpires involved in the pitch but also in-game contextual information like the number of outs, the count, baserunners, and score. We first fit flexible Bayesian nonparametric models to estimate (i) the probability that the pitch is called a strike if the batter takes the pitch; (ii) the probability that the batter makes contact if he swings; and (iii) the number of runs the batting team is expected to score following each pitch outcome (e.g. swing and miss, take a called strike, etc.). We then combine these intermediate estimates to determine whether swinging increases the batting team's run expectancy. Our approach enables natural uncertainty propagation so that we can not only determine the optimal swing/take decision but also quantify our confidence in that decision. We illustrate our framework using a case study of pitches faced by Mike Trout in 2019.

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A Bayesian analysis of the time through the order penalty in baseball

As a baseball game progresses, batters appear to perform better the more times they face a particular pitcher. The apparent drop-off in pitcher performance from one time through the order to the next, known as the Time Through the Order Penalty (TTOP), is often attributed to within-game batter learning. Although the TTOP has largely been accepted within baseball and influences many managers' in-game decision making, we argue that existing approaches of estimating the size of the TTOP cannot disentangle continuous evolution in pitcher performance over the course of the game from discontinuities between successive times through the order. Using a Bayesian multinomial regression model, we find that, after adjusting for confounders like batter and pitcher quality, handedness, and home field advantage, there is little evidence of strong discontinuity in pitcher performance between times through the order. Our analysis suggests that the start of the third time through the order should not be viewed as a special cutoff point in deciding whether to pull a starting pitcher.

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Bayesian Causal Forests & the 2022 ACIC Data Challenge: Scalability and Sensitivity

We demonstrate how Hahn et al.'s Bayesian Causal Forests model (BCF) can be used to estimate conditional average treatment effects for the longitudinal dataset in the 2022 American Causal Inference Conference Data Challenge. Unfortunately, existing implementations of BCF do not scale to the size of the challenge data. Therefore, we developed flexBCF -- a more scalable and flexible implementation of BCF -- and used it in our challenge submission. We investigate the sensitivity of our results to the choice of propensity score estimation method and the use of sparsity-inducing regression tree priors. While we found that our overall point predictions were not especially sensitive to these modeling choices, we did observe that running BCF with flexibly estimated propensity scores often yielded better-calibrated uncertainty intervals.

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