Searcharxiv⌕ Search

arXiv subjects

Sander C. Kammeraat

Publications and source records attributed to Sander C. Kammeraat.

2 recordsLinked to original sources

Active elastic theory of self-aligning solids

Active disordered solids including dense human crowds and epithelial cells under confinement exhibit striking system-scale oscillatory spatiotemporal patterns. These are linked to a local feedback mechanism, self-alignment, that aligns the direction of a particle's motility vector to the total force. Simulations and experiments of solids made of such agents show these spontaneous oscillation patterns. Theoretically, they have been linked to both a nonlinear bifurcation and to selection of long-wavelength normal modes. Here we derive a closed nonlinear equation for the displacement field of active self-aligning 2d solids subject to angular noise. Along the normal modes of the solid, the dynamics of the mode amplitudes correspond to nonlinearly damped and stochastically driven harmonic oscillators. To linear order, we show that the system transitions from Active Brownian type correlated motion to oscillatory motion that increasingly condenses onto the lowest modes of the solid. We compare the analytical predictions for the mode spectra with simulations, finding excellent agreement approaching the transition from the disordered side. Strong nonlinearities manifest deep in the oscillating phase at strong alignment and small noise, consistent with the previous observations. At the continuum level, we derive a closed-form nonlinear wave equation for self-aligning solids. The transition to undamped oscillations is a second order dynamical phase transition driven by the competition between noise and alignment. At the linear level, we predict travelling acto-elastic waves, together with the emergence of system-scale oscillations for confined systems, consistent with observations in tissues and crowds. Our framework extends the understanding of self-aligning solids, which are pervasive among artificial and biological systems across multiple scales.

cond-mat.soft↗

Correlated cell movements drive epithelial finger formation

Epithelia form protective barriers in multicellular organisms. To maintain homeostasis, they must be able to regenerate and heal damaged areas. This occurs through collective cell migration, during which finger-like protrusions commonly appear. Whether these protrusions are driven by specialised leader cells, biochemical cues, or generic physical interactions remains unclear. Integrating in vitro imaging, agent-based simulations, and continuum modelling, we show that correlated active cell motion alone suffices to produce fingers. Leader cells, signalling, and proliferation modulate, but do not trigger, this pattern. Our results show that the key mechanism underlying a complex biological process can be understood using a general framework of the physics of dense active matter.

cond-mat.soft↗