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Santosh Kumar Paidi

Publications and source records attributed to Santosh Kumar Paidi.

2 recordsLinked to original sources

Entity-Centric World Models: Interaction-Aware Masking for Causal Video Prediction

Learning predictive world models from unlabelled video is a foundational challenge in artificial intelligence. While Joint Embedding Predictive Architectures (JEPA) have set new benchmarks in semantic classification, they often remain physics-blind, failing to capture the causal dynamics necessary for downstream reasoning. We hypothesize that this stems from standard patch-based masking strategies, which prioritize visual texture over rare but informative kinematic events. We propose Interaction-Aware JEPA (IA-JEPA), which utilizes a self-supervised motion-centric masking strategy to prioritize physical interactions. By specifically targeting entities engaged in collisions or momentum transfers, we force the architecture to reconstruct latent trajectories rather than static background features. Evaluated on the CLEVRER benchmark, IA-JEPA achieves 14.26% accuracy on causal reasoning tasks, a significant lead over the 3.22% achieved by standard patch-masked baselines. Crucially, we demonstrate that IA-JEPA breaks the "static bias" of standard self-supervision by inducing a higher-entropy, more discriminative latent space (+10% entropy gain) that linearizes physical energy ($R^2=0.43$). We show that this interaction bias generalizes to real-world human actions (Something-Something V2) and zero-shot physical puzzles (PHYRE-Lite). Our results provide a scalable, fully self-supervised path toward building foundational world models that begin to internalize the causal structure of the physical world.

cs.CV

Label-free Raman spectroscopy and machine learning enables sensitive evaluation of differential response to immunotherapy

Cancer immunotherapy provides durable clinical benefit in only a small fraction of patients, particularly due to a lack of reliable biomarkers for accurate prediction of treatment outcomes and evaluation of response. Here, we demonstrate the first application of label-free Raman spectroscopy for elucidating biochemical changes induced by immunotherapy in the tumor microenvironment. We used CT26 murine colorectal cancer cells to grow tumor xenografts and subjected them to treatment with anti-CTLA-4 and anti-PD-L1 antibodies. Multivariate curve resolution - alternating least squares (MCR-ALS) decomposition of Raman spectral dataset obtained from the treated and control tumors revealed subtle differences in lipid, nucleic acid, and collagen content due to therapy. Our supervised classification analysis using support vector machines and random forests provided excellent prediction accuracies for both immune checkpoint inhibitors and delineated important spectral markers specific to each therapy, consistent with their differential mechanisms of action. Our findings pave the way for in vivo studies of response to immunotherapy in clinical patients using label-free Raman spectroscopy and machine learning.

q-bio.QM