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Sara M Clifton

Publications and source records attributed to Sara M Clifton.

2 recordsLinked to original sources

Bystander effect emerges from individual psychological prospects

The bystander effect is a social psychological phenomenon in which individuals are less likely to help a person potentially in need if there are others present. Sociologists and psychologists have proposed multiple plausible reasons for the bystander effect, from situational ambiguity and social contagion to diffusion of responsibility and mutual denial. We build a new model of an individual's decision to intervene in a bystander situation based on these social psychological hypotheses, along with ideas borrowed from prospect theory. This model shows, for the first time, that the bystander effect emerges from social risk perception among non-coordinating individuals in ambiguous bystander situations. Expanding upon this static model, we explore the effect of social learning, where individuals update their perceived risk of intervening after experiencing or witnessing the social repercussions of previous interventions. A novel result of this model is that social learning exacerbates the bystander effect. We validate these models using a new database of 42 experimental and observational studies across a wide range of bystander situations, demonstrating a straightforward and generalizable explanation for the observed phenomenon, which may suggest effective interventions tailored to specific bystander situations.

physics.soc-ph↗

Phage-antibiotic synergy inhibited by temperate and chronic virus competition

As antibiotic resistance grows more frequent for common bacterial infections, alternative treatment strategies such as phage therapy have become more widely studied in the medical field. While many studies have explored the efficacy of antibiotics, phage therapy, or synergistic combinations of phages and antibiotics, the impact of virus competition on the efficacy of antibiotic treatment has not yet been considered. Here, we model the synergy between antibiotics and two viral types, temperate and chronic, in controlling bacterial infections. We demonstrate that while combinations of antibiotic and temperate viruses exhibit synergy, competition between temperate and chronic viruses inhibits bacterial control with antibiotics. In fact, our model reveals that antibiotic treatment may counterintuitively increase the bacterial load when a large fraction of the bacteria develop antibiotic-resistance.

q-bio.PE↗