SearcharxivSearch

arXiv subjects

Sarah Koller

Publications and source records attributed to Sarah Koller.

2 recordsLinked to original sources

The fundamental limit of jet tagging: Beyond top jets

Jet tagging, i.e. determining the origin of high-energy hadronic jets, is a key challenge in particle physics. Machine-learning-based taggers have achieved remarkable progress, raising the question of how close current methods are to the theoretical limit of performance. Previous work addressed this question for boosted top-quark jets using transformer-based generative models that provide realistic synthetic jet data with known probability density functions. This enables a direct comparison between modern taggers and the optimal likelihood-ratio classifier. In this note, we summarize the approach and extend the study to boosted W, Z, and H$\rightarrow gg$ jets. We find that the gap to the estimated optimal limit is strongly jet dependent and is substantially reduced for these seemingly more challenging tagging tasks. Ongoing work aimed at understanding the interpretation, robustness, and scaling of these limits is also briefly discussed.

hep-ph

Nuquantus: Machine learning software for the characterization and quantification of cell nuclei in complex immunofluorescent tissue images

Determination of fundamental mechanisms of disease often hinges on histopathology visualization and quantitative image analysis. Currently, the analysis of multi-channel fluorescence tissue images is primarily achieved by manual measurements of tissue cellular content and sub-cellular compartments. Since the current manual methodology for image analysis is a tedious and subjective approach, there is clearly a need for an automated analytical technique to process large-scale image datasets. Here, we introduce Nuquantus (Nuclei quantification utility software) - a novel machine learning-based analytical method, which identifies, quantifies and classifies nuclei based on cells of interest in composite fluorescent tissue images, in which cell borders are not visible. Nuquantus is an adaptive framework that learns the morphological attributes of intact tissue in the presence of anatomical variability and pathological processes. Nuquantus allowed us to robustly perform quantitative image analysis on remodeling cardiac tissue after myocardial infarction. Nuquantus reliably classifies cardiomyocyte versus non-cardiomyocyte nuclei and detects cell proliferation, as well as cell death in different cell classes. Broadly, Nuquantus provides innovative computerized methodology to analyze complex tissue images that significantly facilitates image analysis and minimizes human bias.

q-bio.QM