arXiv subjects

Sebastian Schulz

Publications and source records attributed to Sebastian Schulz.

At least 19 recordsLinked to original sources

arXiv2026

PREFER: An Ontology for the PREcision FERmentation Community

Precision fermentation relies on microbial cell factories to produce sustainable food, pharmaceuticals, chemicals, and biofuels. Specialized laboratories such as biofoundries are advancing these processes using high-throughput bioreactor platforms, which generate vast datasets. However, the lack of community standards limits data accessibility and interoperability, preventing integration across platforms. In order to address this, we introduce PREFER, an open-source ontology designed to establish a unified standard for bioprocess data. Built in alignment with the widely adopted Basic Formal Ontology (BFO) and connecting with several other community ontologies, PREFER ensures consistency and cross-domain compatibility and covers the whole precision fermentation process. Integrating PREFER into high-throughput bioprocess development workflows enables structured metadata that supports automated cross-platform execution and high-fidelity data capture. Furthermore, PREFER's standardization has the potential to bridge disparate data silos, generating machine-actionable datasets critical for training predictive, robust machine learning models in synthetic biology. This work provides the foundation for scalable, interoperable bioprocess systems and supports the transition toward more data-driven bioproduction.

q-bio.OT↗

arXiv2025

Learning-Driven Annealing with Adaptive Hamiltonian Modification for Solving Large-Scale Problems on Quantum Devices

We present Learning-Driven Annealing (LDA), a framework that links individual quantum annealing evolutions into a global solution strategy to mitigate hardware constraints such as short annealing times and integrated control errors. Unlike other iterative methods, LDA does not tune the annealing procedure (e.g. annealing time or annealing schedule), but instead learns about the problem structure to adaptively modify the problem Hamiltonian. By deforming the instantaneous energy spectrum, LDA suppresses transitions into high-energy states and focuses the evolution into low-energy regions of the Hilbert space. We demonstrate the efficacy of LDA by developing a hybrid quantum-classical solver for large-scale spin glasses. The hybrid solver is based on a comprehensive study of the internal structure of spin glasses, outperforming other quantum and classical algorithms (e.g., reverse annealing, cyclic annealing, simulated annealing, Gurobi, Toshiba's SBM, VeloxQ and D-Wave hybrid) on 5580-qubit problem instances in both runtime and lowest energy. LDA is a step towards practical quantum computation that enables today's quantum devices to compete with classical solvers.

quant-ph↗

arXiv2025

Impact of Seismic Activities on the Optical Synchronization System of the European X-ray Free-Electron Laser

This study investigates the influence of seismic activities on the optical synchronization system of the European X-ray Free-Electron Laser. We analyze the controller I/O data of phase-locked-loops in length-stabilized links, focusing on the response to earthquakes, ocean-generated microseism and civilization noise. By comparing the controller data with external data, we were able to identify disturbances and their effects on the control signals. Our results show that seismic events influence the stability of the phase-locked loops. Even earthquakes that are approximately \qty{5000}{\km} away cause remarkable fluctuations in the in-loop control signals. Ocean-generated microseism in particular has an enormous influence on the in-loop control signals due to its constant presence. The optical synchronization system is so highly sensitive that it can even identify vibrations caused by civilization, such as road traffic or major events like concerts or sport events. The phase-locked loops manages to eliminate more than 99% of the existing interference.

hep-ex↗

arXiv2024

On a conjecture of Simpson

On a compact Riemann surface $\Sigma$ of genus $g\ge 2$, equipped with a complex vector bundle $E$ of rank $2$ and degree zero let $M_H$ be the moduli space of Higgs bundles. $M_H$ admits a $\mathbb C^{\star}$-action and to each stable $\mathbb C^{\star}$-fixed point $[(\bar\partial_0,\Phi_0)]$ is associated a holomorphic Lagrangian submanifold $W^1(\bar\partial_0,\Phi_0)$ inside the de Rham moduli space $M_{dR}$ of complex flat connections. In this note we prove a conjecture of Simpson stating that $W^1(\bar\partial_0,\Phi_0)$ is closed inside $M_{dR}$.

math.DG↗

arXiv2023

Broadband Continuous Spectral Control of a Single Wavelength Polymer-Based Solid-State Random Laser

We demonstrate temperature-controlled spectral tunability of a partially-pumped single-wavelength random laser in a solid-state random laser based on DCM (4-dicyanomethylene-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran) doped PMMA (polymethyl methacrylate) dye. By carefully shaping the spatial profile of the pump, we first achieve low-threshold, single-mode random lasing with excellent side lobes rejection. Notably, we show how temperature-induced changes in the refractive index of the PMMA-DCM layer result in a blue-shift of this single lasing mode. Continuous tunability of the lasing wavelength is demonstrated over an 8nm-wide bandwidth.

physics.optics↗

arXiv2023

Guided quantum walk

We utilize the theory of local amplitude transfers (LAT) to gain insights into quantum walks (QWs) and quantum annealing (QA) beyond the adiabatic theorem. By representing the eigenspace of the problem Hamiltonian as a hypercube graph, we demonstrate that probability amplitude traverses the search space through a series of local Rabi oscillations. We argue that the amplitude movement can be systematically guided towards the ground state using a time-dependent hopping rate based solely on the problem's energy spectrum. Building upon these insights, we extend the concept of multi-stage QW by introducing the guided quantum walk (GQW) as a bridge between QW-like and QA-like procedures. We assess the performance of the GQW on exact cover, traveling salesperson and garden optimization problems with 9 to 30 qubits. Our results provide evidence for the existence of optimal annealing schedules, beyond the requirement of adiabatic time evolutions. These schedules might be capable of solving large-scale combinatorial optimization problems within evolution times that scale linearly in the problem size.

quant-ph↗

arXiv2023

A case study for measuring the relativistic dipole of a galaxy cross-correlation with the Dark Energy Spectroscopic Instrument

The data on spectroscopic galaxy clustering collected by the Dark Energy Spectroscopic Instrument (DESI) will allow the significant detection of subtle features in the galaxy two-point correlation in redshift space, beyond the "standard" redshift-space distortions. Here we present an independent assessment of the detectability of the relativistic dipole in the cross-correlation of two populations of galaxies if they would be selected from the Bright Galaxy Survey (BGS) of DESI. We build synthetic galaxy catalogues with the characteristics of the BGS using the light cone of a relativistic $N$-body simulation. Exploring different ways of splitting the populations of galaxies we find that with an unequal split with more bright galaxies than faint galaxies the detectability is significantly boosted, reaching 19 $\sigma$ in the redshift bin $0.2 \lesssim z \lesssim 0.3$ and expected to be even higher at lower redshift. Moreover, we find that the measured dipole agrees very well with the prediction of relativistic effects from linear theory down to separations of $\sim$ 30 Mpc/$h$.

astro-ph.CO↗

arXiv2023

Glass-Like Random Catalogues for Two-Point Estimates on the Light Cone

We introduce grlic, a publicly available Python tool for generating glass-like point distributions with a radial density profile $n(r)$ as it is observed in large-scale surveys of galaxy distributions on the past light cone. Utilising these glass-like catalogues, we assess the bias and variance of the Landy-Szalay (LS) estimator of the first three two-point correlation function (2PCF) multipoles in halo and particle catalogues created with the cosmological N-body code gevolution. Our results demonstrate that the LS estimator calculated with the glass catalogues is biased by less than $10^{-4}$ with respect to the estimate derived from Poisson-sampled random catalogues, for all multipoles considered and on all but the smallest scales. Additionally, the estimates derived from glass-like catalogues exhibit significantly smaller standard deviation $\sigma$ than estimates based on commonly used Poisson-sampled random catalogues of comparable size. The standard deviation of the estimate depends on a power of the number of objects $N_R$ in the random catalogue; we find a power law $\sigma \propto N_R^{-0.9}$ for glass-like random catalogues as opposed to $\sigma \propto N_R^{-0.48}$ using Poisson-sampled random catalogues. Given a required precision, this allows for a much reduced number of objects in the glass-like random catalogues used for the LS estimate of the 2PCF multipoles, significantly reducing the computational costs of each estimate.

astro-ph.CO↗

arXiv2022

Hybrid Quantum Classical Simulations

We report on two major hybrid applications of quantum computing, namely, the quantum approximate optimisation algorithm (QAOA) and the variational quantum eigensolver (VQE). Both are hybrid quantum classical algorithms as they require incremental communication between a classical central processing unit and a quantum processing unit to solve a problem. We find that the QAOA scales much better to larger problems than random guessing, but requires significant computational resources. In contrast, a coarsely discretised version of quantum annealing called approximate quantum annealing (AQA) can reach the same promising scaling behaviour using much less computational resources. For the VQE, we find reasonable results in approximating the ground state energy of the Heisenberg model when suitable choices of initial states and parameters are used. Our design and implementation of a general quasi-dynamical evolution further improves these results.

quant-ph↗

arXiv2022

The halo bias for number counts on the light cone from relativistic N-body simulations

We present the halo number counts and its two-point statistics, the observable angular power spectrum, extracted for the first time from relativistic N-body simulations. The halo catalogues used in this work are built from the relativistic N-body code gevolution, and the observed redshift and angular positions of the sources are computed using a non-perturbative ray-tracing method, which includes all relativistic scalar contributions to the number counts. We investigate the validity and limitations of the linear bias prescription to describe our simulated power spectra. In particular, we assess the consistency of different bias measurements on large scales, and we estimate up to which scales a linear bias is accurate in modelling the data, within the statistical errors. We then test a second-order perturbative bias expansion for the angular statistics, on a range of redshifts and scales previously unexplored in this context, that is $0.4 \le \bar{z} \le 2$ up to scales $\ell_\mathrm{max} \sim 1000$. We find that the angular power spectra at equal redshift can be modelled with high accuracy with a minimal extension of the number of bias parameters, that is using a two-parameter model comprising linear bias and tidal bias. We show that this model performs significantly better than a model without tidal bias but with quadratic bias as extra degree of freedom, and that the latter is inaccurate at $\bar{z} \ge 0.7$. Finally, we extract from our simulations the cross-correlation of halo number counts and lensing convergence. We show that the estimate of the linear bias from this cross-correlation is consistent with the measurements based on the clustering statistics alone, and that it is crucial to take into account the effect of magnification in the halo number counts to avoid systematic shifts in the computed bias.

astro-ph.CO↗

arXiv2022

Nilpotent Higgs bundles and families of flat connections

We investigate $\mathbb{C}^\times$-families of flat connections whose leading term is a nilpotent Higgs field. Examples of such families include real twistor lines and families arising from the conformal limit. We show that these families have the same monodromy as families whose leading term is a regular Higgs bundle and use this to deduce that traces of holonomies are asymptotically exponential in rational powers of the parameter of the family.

math.DG↗

arXiv2021

Ultrafast MHz-rate burst-mode pump-probe laser for the FLASH FEL facility based on nonlinear compression of ps-level pulses from an Yb-amplifier chain

The Free-Electron Laser (FEL) FLASH offers the worldwide still unique capability to study ultrafast processes with high-flux, high-repetition rate XUV and soft X-ray pulses. The vast majority of experiments at FLASH are of pump-probe type. Many of them rely on optical ultrafast lasers. Here, a novel FEL facility laser is reported which combines high average power output from Yb:YAG amplifiers with spectral broadening in a Herriott-type multi-pass cell and subsequent pulse compression to sub-100 fs durations. Compared to other facility lasers employing optical parametric amplification, the new system comes with significantly improved noise figures, compactness, simplicity and power efficiency. Like FLASH, the optical laser operates with 10 Hz burst repetition rate. The bursts consist of 800 $\mu$s long trains of up to 800 ultrashort pulses being synchronized to the FEL with femtosecond precision. In the experimental chamber, pulses with up to 50 $\mu$J energy, 60 fs FWHM duration and 1 MHz rate at 1.03 $\mu$m wavelength are available and can be adjusted by computer-control. Moreover, nonlinear polarization rotation is implemented to improve laser pulse contrast. First cross-correlation measurements with the FEL at the plane-grating monochromator photon beamline are demonstrated, exhibiting the suitability of the laser for user experiments at FLASH.

physics.optics↗

arXiv2021

The dust-continuum size of TNG50 galaxies at $z=1-5$: a comparison with the distribution of stellar light, stars, dust and H$_2$

We present predictions for the extent of the dust-continuum emission of thousands of main-sequence galaxies drawn from the TNG50 simulation between $z=1-5$. To this aim, we couple the radiative transfer code SKIRT to the output of the TNG50 simulation and measure the dust-continuum half-light radius of the modeled galaxies, assuming a Milky Way dust type and a metallicity dependent dust-to-metal ratio. The dust-continuum half-light radius at observed-frame 850 $\mu$m is up to $\sim$75 per cent larger than the stellar half-mass radius, but significantly more compact than the observed-frame 1.6 $\mu$m (roughly corresponding to H-band) half-light radius, particularly towards high redshifts: the compactness compared to the 1.6 $\mu$m emission increases with redshift. This is driven by obscuration of stellar light from the galaxy centres, which increases the apparent extent of 1.6 $\mu$m disk sizes relative to that at 850 $\mu$m. The difference in relative extents increases with redshift because the observed-frame 1.6 $\mu$m emission stems from ever shorter wavelength stellar emission. These results suggest that the compact dust-continuum emission observed in $z>1$ galaxies is not (necessarily) evidence of the buildup of a dense central stellar component. We also find that the dust-continuum half-light radius very closely follows the radius containing half the star formation in galaxies, indicating that single band dust-continuum emission is a good tracer of the location of (obscured) star formation. The dust-continuum emission is more compact than the H2 mass (for galaxies at $z\geq 2$) and the underlying dust mass. The dust emission strongly correlates with locations with the highest dust temperatures, which do not need to be the locations where most H$_2$ and/or dust is located. The presented results are a common feature of main-sequence galaxies.

astro-ph.GA↗

arXiv2020

Thermo-Optically Induced Transparency on a photonic chip

Controlling the optical response of a medium through suitably tuned coherent electromagnetic fields is highly relevant in a number of potential applications, from all-optical modulators to optical storage devices. In particular, electromagnetically induced transparency (EIT) is an established phenomenon in which destructive quantum interference creates a transparency window over a narrow spectral range around an absorption line, which, in turn, allows to slow and ultimately stop light due to the anomalous refractive index dispersion. Here we report on the observation of a new form of either induced transparency or amplification of a weak probe beam in a strongly driven silicon photonic crystal resonator at room temperature. The effect is based on the oscillating temperature field induced in a nonlinear optical cavity, and it reproduces many of the key features of EIT while being independent of either atomic or mechanical resonances. Such thermo-optically induced transparency (TOIT) will allow a versatile implementation of EIT-analogues in an integrated photonic platform, at almost arbitrary wavelength of interest, room temperature and in a practical, low cost and scalable system.

physics.optics↗

arXiv2020

Triality for Homogeneous Polynomials

Through the triality of ${\rm SO}(8,\mathbb{C})$, we study three interrelated homogeneous basis of the ring of invariant polynomials of Lie algebras, which give the basis of three Hitchin fibrations, and identify the explicit automorphisms that relate them.

math.RA↗

arXiv2020

A self-referenced in-situ arrival time monitor for X-ray free-electron lasers

We present a novel, highly versatile, and self-referenced arrival time monitor for measuring the femtosecond time delay between a hard X-ray pulse from a free-electron laser and an optical laser pulse, measured directly on the same sample used for pump-probe experiments. Two chirped and picosecond long optical supercontinuum pulses traverse the sample with a mutually fixed time delay of 970 fs, while a femtosecond X-ray pulse arrives at an instant in between both pulses. Behind the sample the supercontinuum pulses are temporally overlapped to yield near-perfect destructive interference in the absence of the X-ray pulse. Stimulation of the sample with an X-ray pulse delivers non-zero contributions at certain optical wavelengths, which serve as a measure of the relative arrival time of the X-ray pulse with an accuracy of better than 25 fs. We find an excellent agreement of our monitor with the existing timing diagnostics at the SACLA XFEL with a Pearson correlation value of 0.98. We demonstrate a high sensitivity to measure X-ray pulses with pulse energies as low as 30 $\mu$J. Using a free-flowing liquid jet as interaction sample ensures the full replacement of the sample volume for each X-ray/optical event, thus enabling its utility even at MHz repetition rate XFEL sources.

physics.optics↗

arXiv2020

Femtosecond X-ray emission study of the spin cross-over dynamics in haem proteins

In haemoglobin (consisting of four globular myoglobin-like subunits), the change from the low-spin (LS) hexacoordinated haem to the high spin (HS) pentacoordinated domed form upon ligand detachment and the reverse process upon ligand binding, represent the transition states that ultimately drive the respiratory function. Visible-ultraviolet light has long been used to mimic the ligand release from the haem by photodissociation, while its recombination was monitored using time-resolved infrared to ultraviolet spectroscopic tools. However, these are neither element- nor spin-sensitive. Here we investigate the transition state in the case of Myoglobin-NO (MbNO) using femtosecond Fe Kalpha and Kbeta non-resonant X-ray emission spectroscopy (XES) at an X-ray free-electron laser upon photolysis of the Fe-NO bond. We find that the photoinduced change from the LS (S = 1/2) MbNO to the HS (S = 2) deoxy-myoglobin (deoxyMb) haem occurs in ca. 800 fs, and that it proceeds via an intermediate (S = 1) spin state. The XES observables also show that upon NO recombination to deoxyMb, the return to the planar MbNO ground state is an electronic relaxation from HS to LS taking place in ca. 30 ps. Thus, the entire ligand dissociation-recombination cycle in MbNO is a spin cross-over followed by a reverse spin cross-over process.

physics.chem-ph↗

arXiv2020

A redshift-dependent IRX-$\beta$ dust attenuation relation for TNG50 galaxies

We study the relation between the UV-slope, $\beta$, and the ratio between the infrared- and UV-luminosities (IRX) of galaxies from TNG50, the latest installment of the IllustrisTNG galaxy formation simulations. We select 7280 star-forming main-sequence (SFMS) galaxies with stellar mass $10^9M_\odot$ at redshifts $0 \leq z \leq 4$ and perform radiative transfer with SKIRT to model effects of interstellar medium dust on the emitted stellar light. Assuming a Milky Way (MW) dust type and a dust-to-metal ratio of 0.3, we find that TNG50 SFMS galaxies generally agree with observationally-derived IRX-$\beta$ relations at $z \lesssim 1$. However, we find a redshift-dependent systematic offset with respect to empirically-derived local relations, with the TNG50 IRX-$\beta$ relation shifting towards lower $\beta$ and steppening at higher redshifts. This is partially driven by variations in the dust-uncorrected UV-slope of galaxies, due to different star-formation histories of galaxies selected at different cosmic epochs; we suggest the remainder of the effect is caused by differences in the effective dust attenuation curves (EDACs) of galaxies as a function of redshift. We find a typical galaxy-to-galaxy variation of 0.3 dex in IRX at fixed $\beta$, correlated with intrinsic galaxy properties: galaxies with higher star-formation rates, star-formation efficiencies, gas metallicities and stellar masses exhibit larger IRX values. We demonstrate a degeneracy between stellar age, dust geometry and dust composition: $z=4$ galaxies with a Small Magellanic Cloud dust type follow the same IRX-$\beta$ relation as low-redshift galaxies with MW dust. We provide a redshift-dependent fitting function for the IRX-$\beta$ relation for MW dust based on our models.

astro-ph.GA↗