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Sergei Izrailev

Publications and source records attributed to Sergei Izrailev.

2 recordsLinked to original sources

Machine Learning at Scale

It takes skill to build a meaningful predictive model even with the abundance of implementations of modern machine learning algorithms and readily available computing resources. Building a model becomes challenging if hundreds of terabytes of data need to be processed to produce the training data set. In a digital advertising technology setting, we are faced with the need to build thousands of such models that predict user behavior and power advertising campaigns in a 24/7 chaotic real-time production environment. As data scientists, we also have to convince other internal departments critical to implementation success, our management, and our customers that our machine learning system works. In this paper, we present the details of the design and implementation of an automated, robust machine learning platform that impacts billions of advertising impressions monthly. This platform enables us to continuously optimize thousands of campaigns over hundreds of millions of users, on multiple continents, against varying performance objectives.

cs.LG↗

Unbinding of Retinoic Acid from its Receptor Studied by Steered Molecular Dynamics

Retinoic acid receptor (RAR) is a ligand-dependent transcription factor that regulates the expression of genes involved in cell growth, differentiation, and development. Binding of the retinoic acid hormone to RAR is accompanied by conformational changes in the protein which induce transactivation or transrepression of the target genes. In this paper we present a study of the hormone binding/unbinding process in order to clarify the role of some of the amino acid contacts and identify possible pathways of the all-trans retinoic acid binding/unbinding to/from human retinoic acid receptor (hRAR)-g. Three possible pathways were explored using steered molecular dynamics simulations. Unbinding was induced on a time scale of 1 ns by applying external forces to the hormone. The simulations suggest that the hormone may employ one pathway for binding and an alternative "back door" pathway for unbinding.

physics.bio-ph↗