arXiv subjects

Seungyong Hwang

Publications and source records attributed to Seungyong Hwang.

3 recordsLinked to original sources

arXiv2026

Estimating Spatially-Smoothed Fiber Orientation Distribution from Diffusion-MRI Experiments

Diffusion-weighted magnetic resonance imaging (D-MRI) is a noninvasive in vivo technique for probing the microstructural architecture of biological tissues. At each voxel, the fiber orientation distribution (FOD) characterizes local fiber configurations and orientations and is therefore a central object of estimation in D-MRI analysis. We propose the Nearest-Neighbor Adaptive Regression Model (NARM), a spatially adaptive framework for FOD estimation that performs weighted local likelihood estimation over nested spatial neighborhoods, where the weights jointly encode spatial proximity and similarity among neighboring FODs, measured by either the optimal transport or Hellinger distance. To prevent over-smoothing while preserving structural heterogeneity, we introduce a voxel-wise rescaling scheme and a data-driven stopping rule based on minimum nearest-neighbor dissimilarity. We further develop a configuration-aware strategy for selecting the similarity-smoothing parameter, allowing the smoothing strength to adapt to local fiber complexity. Simulation studies demonstrate that NARM improves FOD estimation accuracy relative to voxel-wise methods and the existing spatial smoothing approach PMARM. Application to test-retest data from the Human Connectome Project additionally shows that NARM yields more reproducible FOD estimates. Implementation details and scripts for the simulation and real data analyses are available at https://github.com/jie108/NARM

stat.AP↗

arXiv2021

Estimating Fiber Orientation Distribution through Blockwise Adaptive Thresholding with Application to HCP Young Adults Data

Due to recent technological advances, large brain imaging data sets can now be collected. Such data are highly complex so extraction of meaningful information from them remains challenging. Thus, there is an urgent need for statistical procedures that are computationally scalable and can provide accurate estimates that capture the neuronal structures and their functionalities. We propose a fast method for estimating the fiber orientation distribution(FOD) based on diffusion MRI data. This method models the observed dMRI signal at any voxel as a convolved and noisy version of the underlying FOD, and utilizes the spherical harmonics basis for representing the FOD, where the spherical harmonic coefficients are adaptively and nonlinearly shrunk by using a James-Stein type estimator. To further improve the estimation accuracy by enhancing the localized peaks of the FOD, as a second step a super-resolution sharpening process is then applied. The resulting estimated FODs can be fed to a fiber tracking algorithm to reconstruct the white matter fiber tracts. We illustrate the overall methodology using both synthetic data and data from the Human Connectome Project.

stat.AP↗

arXiv2020

Simultaneous Detection of Multiple Change Points and Community Structures in Time Series of Networks

In many complex systems, networks and graphs arise in a natural manner. Often, time evolving behavior can be easily found and modeled using time-series methodology. Amongst others, two common research problems in network analysis are community detection and change-point detection. Community detection aims at finding specific sub-structures within the networks, and change-point detection tries to find the time points at which sub-structures change. We propose a novel methodology to detect both community structures and change points simultaneously based on a model selection framework in which the Minimum Description Length Principle (MDL) is utilized as minimizing objective criterion. The promising practical performance of the proposed method is illustrated via a series of numerical experiments and real data analysis.

cs.SI↗