Shawn Ahn | Searcharxiv

arXiv2024

Assessment of Clonal Hematopoiesis of Indeterminate Potential and Future Cardiomyopathy from Cardiac Magnetic Resonance Imaging using Deep Learning in a Cardio-oncology Population

We propose a novel deep learning framework to identify clonal hematopoiesis of indeterminate potential (CHIP), a somatic mutation condition associated with adverse cardiovascular outcomes, using routine cardiac magnetic resonance (CMR) imaging. Utilizing 152 multi-view late gadolinium enhancement (LGE) scans from 136 cardio-oncology patients, we developed a convolutional neural network to (1) detect CHIP status and (2) stratify the risk of future cardiomyopathy specifically within the CHIP-positive cohort. To ensure robustness, we performed rigorous feature importance analysis to rule out reliance on demographic confounders such as age and immune checkpoint inhibitor usage. The model achieved an AUC of 0.71 for CHIP detection and, notably, an AUC of 0.87 for predicting future cardiomyopathy in CHIP-positive patients, significantly outperforming demographic-only baselines. These results demonstrate the feasibility of using LGE-CMR signatures as a non-invasive "radiogenomic" screening tool, potentially enabling accessible risk stratification and precision medicine for high-risk cardiovascular populations.

eess.IV↗

arXiv2022

Learning correspondences of cardiac motion from images using biomechanics-informed modeling

Learning spatial-temporal correspondences in cardiac motion from images is important for understanding the underlying dynamics of cardiac anatomical structures. Many methods explicitly impose smoothness constraints such as the $\mathcal{L}_2$ norm on the displacement vector field (DVF), while usually ignoring biomechanical feasibility in the transformation. Other geometric constraints either regularize specific regions of interest such as imposing incompressibility on the myocardium or introduce additional steps such as training a separate network-based regularizer on physically simulated datasets. In this work, we propose an explicit biomechanics-informed prior as regularization on the predicted DVF in modeling a more generic biomechanically plausible transformation within all cardiac structures without introducing additional training complexity. We validate our methods on two publicly available datasets in the context of 2D MRI data and perform extensive experiments to illustrate the effectiveness and robustness of our proposed methods compared to other competing regularization schemes. Our proposed methods better preserve biomechanical properties by visual assessment and show advantages in segmentation performance using quantitative evaluation metrics. The code is publicly available at \url{https://github.com/Voldemort108X/bioinformed_reg}.

eess.IV↗