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Shihong Chen

Publications and source records attributed to Shihong Chen.

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EFT-CoT: A Multi-Agent Chain-of-Thought Framework for Emotion-Focused Therapy

The use of large language models (LLMs) for Mental Health Question Answering (MHQA) offers a promising way to alleviate shortages in mental health resources. However, prior work has mainly relied on Cognitive Behavioral Therapy (CBT) and predominantly follows a top-down strategy centered on rational cognitive restructuring, providing limited support for embodied experience and primary emotion processing. To address this gap, we propose EFT-CoT, a multi-agent chain-of-thought framework grounded in Emotion-Focused Therapy (EFT). EFT-CoT operationalizes intervention as a three-stage workflow: Embodied Perception, Cognitive Exploration, and Narrative Intervention. The framework employs eight specialized agents to model key processes including somatic awareness mapping, adaptive evaluation, core belief extraction, and narrative restructuring. Based on this framework, we construct EFT-Instruct, a high-quality instruction-tuning dataset built from process-level augmentation of about 67,000 real help-seeking texts, and further fine-tune a dedicated model, EFT-LLM. Experiments show that EFT-LLM consistently outperforms strong baselines and human responses in empathic depth and structural professionalism. Ablation studies further verify the contribution of key mechanisms, while white-box auditing demonstrates the consistency and traceability of critical intermediate states. Overall, this work provides a reproducible framework-data-model pipeline for embedding EFT mechanisms into LLM-based mental health support.

cs.CL

Monitoring Nitric Oxide in Trigeminal Neuralgia Rats with a Cerium Single-Atom Nanozyme Electrochemical Biosensor

Trigeminal neuralgia (TN) is the most common neuropathic disorder; however, its pathogenesis remains unclear. A prevailing theory suggests that nitric oxide (NO) may induce nerve compression and irritation via vascular dilation, thereby being responsible for the condition, making real-time detection of generated NO critical. However, traditional evaluations of NO rely on indirect colorimetric or chemiluminescence techniques, which offer limited sensitivity and spatial resolution for its real-time assessment in biological environments. Herein, we reported the development of a highly sensitive NO electrochemical biosensor based cerium single-atom nanozyme (Ce1-CN) with ultrawide linear range from 1.08 nM to 143.9 {\mu}M, and ultralow detection limit of 0.36 nM, which enables efficient and real-time evaluation of NO in TN rats. In-situ attenuated total reflection surface-enhanced infrared spectroscopy combined with density functional theory calculations revealed the high-performance biosensing mechanism, whereby the Ce centers in Ce1-CN nanoenzymes adsorb NO and subsequently react with OH- to form *HNO2. Results demonstrated that NO concentration was associated with TN onset. Following carbamazepine treatment, NO production from nerves decreased, accompanied by an alleviation of pain. These findings indicate that the biosensor serves as a valuable tool for investigating the pathogenesis of TN and guiding subsequent therapeutic strategies.

q-bio.BM