Shijie Yan | Searcharxiv

arXiv2025

Accelerating mesh-based Monte Carlo simulations using contemporary graphics ray-tracing hardware

Significance: Monte Carlo (MC) methods are the gold-standard for modeling light-tissue interactions due to their accuracy. Mesh-based MC (MMC) offers enhanced precision for complex tissue structures using tetrahedral mesh models. Despite significant speedups achieved on graphics processing units (GPUs), MMC performance remains hindered by the computational cost of frequent ray-boundary intersection tests. Aim: We propose a highly accelerated MMC algorithm, RT-MMC, that leverages the hardware-accelerated ray traversal and intersection capabilities of ray-tracing cores (RT-cores) on modern GPUs. Approach: Implemented using NVIDIA's OptiX platform, RT-MMC extends graphics ray-tracing pipelines towards volumetric ray-tracing in turbid media, eliminating the need for challenging tetrahedral mesh generation while delivering significant speed improvements through hardware acceleration. It also intrinsically supports wide-field sources without complex mesh retesselation. Results: RT-MMC demonstrates excellent agreement with traditional software-ray-tracing MMC algorithms while achieving 1.5x to 4.5x speedups across multiple GPU architectures. These performance gains significantly enhance the practicality of MMC for routine simulations. Conclusion: Migration from software- to hardware-based ray-tracing not only greatly simplifies MMC simulation workflows, but also results in significant speedups that are expected to increase further as ray-tracing hardware rapidly gains adoption. Adoption of graphics ray-tracing pipelines in quantitative MMC simulations enables leveraging of emerging hardware resources and benefits a wide range of biophotonics applications.

cs.DC↗

arXiv2025

Inferring Optical Tissue Properties from Photoplethysmography using Hybrid Amortized Inference

Smart wearables enable continuous tracking of established biomarkers such as heart rate, heart rate variability, and blood oxygen saturation via photoplethysmography (PPG). Beyond these metrics, PPG waveforms contain richer physiological information, as recent deep learning (DL) studies demonstrate. However, DL models often rely on features with unclear physiological meaning, creating a tension between predictive power, clinical interpretability, and sensor design. We address this gap by introducing PPGen, a biophysical model that relates PPG signals to interpretable physiological and optical parameters. Building on PPGen, we propose hybrid amortized inference (HAI), enabling fast, robust, and scalable estimation of relevant physiological parameters from PPG signals while correcting for model misspecification. In extensive in-silico experiments, we show that HAI can accurately infer physiological parameters under diverse noise and sensor conditions. Our results illustrate a path toward PPG models that retain the fidelity needed for DL-based features while supporting clinical interpretation and informed hardware design.

cs.LG↗