arXiv subjects
Publications and source records attributed to Shinnosuke Seki.
Mateescu, Salomaa, and Yu asked: is it decidable whether a given subword history assumes only non-negative values for all words over a given alphabet. In this paper, we solve this open problem by proving that this problem is undecidable even under stronger conditions than supposed originally.
Hairpin completion is an abstract operation modeling a DNA bio-operation which receives as input a DNA strand $w = xαy \calpha$, and outputs $w' = x αy \barα \bar{x}$, where $\bar{x}$ denotes the Watson-Crick complement of $x$. In this paper, we focus on the problem of finding conditions under which the iterated hairpin completion of a given word is regular. According to the numbers of words $α$ and $\calpha$ that initiate hairpin completion and how they are scattered, we classify the set of all words $w$. For some basic classes of words $w$ containing small numbers of occurrences of $α$ and $\calpha$, we prove that the iterated hairpin completion of $w$ is regular. For other classes with higher numbers of occurrences of $α$ and $\calpha$, we prove a necessary and sufficient condition for the iterated hairpin completion of a word in these classes to be regular.
Winfree's abstract Tile Assembly Model (aTAM) is a model of molecular self-assembly of DNA complexes known as tiles, which float freely in solution and attach one at a time to a growing "seed" assembly based on specific binding sites on their four sides. We show that there is a polynomial-time algorithm that, given an n x n square, finds the minimal tile system (i.e., the system with the smallest number of distinct tile types) that uniquely self-assembles the square, answering an open question of Adleman, Cheng, Goel, Huang, Kempe, Moisset de Espanes, and Rothemund ("Combinatorial Optimization Problems in Self-Assembly", STOC 2002). Our investigation leading to this algorithm reveals other positive and negative results about the relationship between the size of a tile system and its "temperature" (the binding strength threshold required for a tile to attach).
We investigate the role of nondeterminism in Winfree's abstract Tile Assembly Model (aTAM), which was conceived to model artificial molecular self-assembling systems constructed from DNA. Of particular practical importance is to find tile systems that minimize resources such as the number of distinct tile types, each of which corresponds to a set of DNA strands that must be custom-synthesized in actual molecular implementations of the aTAM. We seek to identify to what extent the use of nondeterminism in tile systems affects the resources required by such molecular shape-building algorithms. We first show a "molecular computability theoretic" result: there is an infinite shape S that is uniquely assembled by a tile system but not by any deterministic tile system. We then show an analogous phenomenon in the finitary "molecular complexity theoretic" case: there is a finite shape S that is uniquely assembled by a tile system with c tile types, but every deterministic tile system that uniquely assembles S has more than c tile types. In fact we extend the technique to derive a stronger (classical complexity theoretic) result, showing that the problem of finding the minimum number of tile types that uniquely assemble a given finite shape is Sigma-P-2-complete. In contrast, the problem of finding the minimum number of deterministic tile types that uniquely assemble a shape was shown to be NP-complete by Adleman, Cheng, Goel, Huang, Kempe, Moisset de Espanés, and Rothemund (Combinatorial Optimization Problems in Self-Assembly, STOC 2002). The conclusion is that nondeterminism confers extra power to assemble a shape from a small tile system, but unless the polynomial hierarchy collapses, it is computationally more difficult to exploit this power by finding the size of the smallest tile system, compared to finding the size of the smallest deterministic tile system.
We propose a novel theoretical biomolecular design to implement any Boolean circuit using the mechanism of DNA strand displacement. The design is scalable: all species of DNA strands can in principle be mixed and prepared in a single test tube, rather than requiring separate purification of each species, which is a barrier to large-scale synthesis. The design is time-responsive: the concentration of output species changes in response to the concentration of input species, so that time-varying inputs may be continuously processed. The design is digital: Boolean values of wires in the circuit are represented as high or low concentrations of certain species, and we show how to construct a single-input, single-output signal restoration gate that amplifies the difference between high and low, which can be distributed to each wire in the circuit to overcome signal degradation. This means we can achieve a digital abstraction of the analog values of concentrations. Finally, the design is energy-efficient: if input species are specified ideally (meaning absolutely 0 concentration of unwanted species), then output species converge to their ideal concentrations at steady-state, and the system at steady-state is in (dynamic) equilibrium, meaning that no energy is consumed by irreversible reactions until the input again changes. Drawbacks of our design include the following. If input is provided non-ideally (small positive concentration of unwanted species), then energy must be continually expended to maintain correct output concentrations even at steady-state. In addition, our fuel species - those species that are permanently consumed in irreversible reactions - are not "generic"; each gate in the circuit is powered by its own specific type of fuel species. Hence different circuits must be powered by different types of fuel. Finally, we require input to be given according to the dual-rail convention, so that an input of 0 is specified not only by the absence of a certain species, but by the presence of another. That is, we do not construct a "true NOT gate" that sets its output to high concentration if and only if its input's concentration is low. It remains an open problem to design scalable, time-responsive, digital, energy-efficient molecular circuits that additionally solve one of these problems, or to prove that some subset of their resolutions are mutually incompatible.
We discuss the self-assembly system of triangular tiles instead of square tiles, in particular right triangular tiles and equilateral triangular tiles. We show that the triangular tile assembly system, either deterministic or non-deterministic, has the same power to the square tile assembly system in computation, which is Turing universal. By providing counter-examples, we show that the triangular tile assembly system and the square tile assembly system are not comparable in general. More precisely, there exists square tile assembly system S such that no triangular tile assembly system is a division of S and produces the same shape; there exists triangular tile assembly system T such that no square tile assembly system produces the same compatible shape with border glues. We also discuss the assembly of triangles by triangular tiles and obtain results similar to the assembly of squares, that is to assemble a triangular of size O(N^2), the minimal number of tiles required is in O(log N/log log N).
A pseudo-primitive word with respect to an antimorphic involution θis a word which cannot be written as a catenation of occurrences of a strictly shorter word t and θ(t). Properties of pseudo-primitive words are investigated in this paper. These properties link pseudo-primitive words with essential notions in combinatorics on words such as primitive words, (pseudo)-palindromes, and (pseudo)-commutativity. Their applications include an improved solution to the extended Lyndon-Schützenberger equation u_1 u_2 ... u_l = v_1 ... v_n w_1 ... w_m, where u_1, ..., u_l \in {u, θ(u)}, v_1, ..., v_n \in {v, θ(v)}, and w_1, ..., w_m \in {w, \theata(w)} for some words u, v, w, integers l, n, m \ge 2, and an antimorphic involution θ. We prove that for l \ge 4, n,m \ge 3, this equation implies that u, v, w can be expressed in terms of a common word t and its image θ(t). Moreover, several cases of this equation where l = 3 are examined.