arXiv subjects

Shintaro Yuki

Publications and source records attributed to Shintaro Yuki.

4 recordsLinked to original sources

arXiv2026

Principal component-guided sparse reduced-rank regression

Reduced-rank regression estimates regression coefficients by imposing a low-rank constraint on the matrix of regression coefficients, thereby accounting for correlations among response variables. To further improve predictive accuracy and model interpretability, several regularized reduced-rank regression methods have been proposed. However, these existing methods cannot bias the regression coefficients toward the leading principal component directions while accounting for the correlation structure among explanatory variables. In addition, when the explanatory variables exhibit a group structure, the correlation structure within each group cannot be adequately incorporated. To overcome these limitations, we propose a new method that introduces pcLasso into the reduced-rank regression framework. The proposed method improves predictive accuracy by accounting for the correlation among response variables while strongly biasing the matrix of regression coefficients toward principal component directions with large variance. Furthermore, even in settings where the explanatory variables possess a group structure, the proposed method is capable of explicitly incorporating this structure into the estimation process. Finally, we illustrate the effectiveness of the proposed method through numerical simulations and real data application.

stat.ME↗

arXiv2024

Estimating heterogeneous treatment effects by W-MCM based on Robust reduced rank regression

Recently, from the personalized medicine perspective, there has been an increased demand to identify subgroups of subjects for whom treatment is effective. Consequently, the estimation of heterogeneous treatment effects (HTE) has been attracting attention. While various estimation methods have been developed for a single outcome, there are still limited approaches for estimating HTE for multiple outcomes. Accurately estimating HTE remains a challenge especially for datasets where there is a high correlation between outcomes or the presence of outliers. Therefore, this study proposes a method that uses a robust reduced-rank regression framework to estimate treatment effects and identify effective subgroups. This approach allows the consideration of correlations between treatment effects and the estimation of treatment effects with an accurate low-rank structure. It also provides robust estimates for outliers. This study demonstrates that, when treatment effects are estimated using the reduced rank regression framework with an appropriate rank, the expected value of the estimator equals the treatment effect. Finally, we illustrate the effectiveness and interpretability of the proposed method through simulations and real data examples.

stat.ME↗

arXiv2024

Extension of W-method and A-learner for multiple binary outcomes

In this study, we compared two groups, in which subjects were assigned to either the treatment or the control group. In such trials, if the efficacy of the treatment cannot be demonstrated in a population that meets the eligibility criteria, identifying the subgroups for which the treatment is effective is desirable. Such subgroups can be identified by estimating heterogeneous treatment effects (HTE). In recent years, methods for estimating HTE have increasingly relied on complex models. Although these models improve the estimation accuracy, they often sacrifice interpretability. Despite significant advancements in the methods for continuous or univariate binary outcomes, methods for multiple binary outcomes are less prevalent, and existing interpretable methods, such as the W-method and A-learner, while capable of estimating HTE for a single binary outcome, still fail to capture the correlation structure when applied to multiple binary outcomes. We thus propose two methods for estimating HTE for multiple binary outcomes: one based on the W-method and the other based on the A-learner. We also demonstrate that the conventional A-learner introduces bias in the estimation of the treatment effect. The proposed method employs a framework based on reduced-rank regression to capture the correlation structure among multiple binary outcomes. We correct for the bias inherent in the A-learner estimates and investigate the impact of this bias through numerical simulations. Finally, we demonstrate the effectiveness of the proposed method using a real data application.

stat.ME↗

arXiv2021

Estimation and visualization of treatment effects for multiple outcomes

We consider a randomized controlled trial between two groups. The objective is to identify a population with characteristics such that the test therapy is more effective than the control therapy. Such a population is called a subgroup. This identification can be made by estimating the treatment effect and identifying interactions between treatments and covariates. To date, many methods have been proposed to identify subgroups for a single outcome. There are also multiple outcomes, but they are difficult to interpret and cannot be applied to outcomes other than continuous values. In this paper, we propose a multivariate regression method that introduces latent variables to estimate the treatment effect on multiple outcomes simultaneously. The proposed method introduces latent variables and adds Lasso sparsity constraints to the estimated loadings to facilitate the interpretation of the relationship between outcomes and covariates. The framework of the generalized linear model makes it applicable to various types of outcomes. Interpretation of subgroups is made by visualizing treatment effects and latent variables. This allows us to identify subgroups with characteristics that make the test therapy more effective for multiple outcomes. Simulation and real data examples demonstrate the effectiveness of the proposed method.

stat.ME↗