Shinwoo Kim | Searcharxiv

arXiv2026

SSP-based construction of evaluation-annotated data for fine-grained aspect-based sentiment analysis

We report the construction of a Korean evaluation-annotated corpus, hereafter called 'Evaluation Annotated Dataset (EVAD)', and its use in Aspect-Based Sentiment Analysis (ABSA) extended in order to cover e-commerce reviews containing sentiment and non-sentiment linguistic patterns. The annotation process uses Semi-Automatic Symbolic Propagation (SSP). We built extensive linguistic resources formalized as a Finite-State Transducer (FST) to annotate corpora with detailed ABSA components in the fashion e-commerce domain. The ABSA approach is extended, in order to analyze user opinions more accurately and extract more detailed features of targets, by including aspect values in addition to topics and aspects, and by classifying aspectvalue pairs depending whether values are unary, binary, or multiple. For evaluation, the KoBERT and KcBERT models are trained on the annotated dataset, showing robust performances of F1 0.88 and F1 0.90, respectively, on recognition of aspect-value pairs.

cs.CL↗

arXiv2024

DeepBioisostere: Discovering Bioisosteres with Deep Learning for a Fine Control of Multiple Molecular Properties

Optimizing molecular properties while preserving biological activity is a central challenge in drug design. Bioisosteric replacement, which substitutes a molecular fragment with a chemically or biologically analogous moiety, offers a powerful strategy for fine-tuning properties without disrupting target binding. However, existing in silico approaches often rely on expert-defined modification sites or suffer from modulating multiple molecular properties simultaneously. Here, we present DeepBioisostere, a deep generative model that performs end-to-end bioisosteric replacement by autonomously selecting and substituting molecular fragments to satisfy multiple target properties. The model captures complex relationships across the molecular graph, enabling the optimization of sophisticated properties such as drug-likeness and synthetic accessibility. By learning from experimental bio-assay data, DeepBioisostere proposes replacements that maintain biological activities, even generating potential bioisosteres beyond the training data. We demonstrate the effectiveness of the model in computational hit-to-lead optimization scenarios, highlighting its potential to accelerate rational molecular design without relying on expert heuristics or pre-established substitution rules.

q-bio.BM↗