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Shiyang Ma

Publications and source records attributed to Shiyang Ma.

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PriFFT: Privacy-preserving Federated Fine-tuning of Large Language Models via Hybrid Secret Sharing

Fine-tuning large language models (LLMs) raises privacy concerns due to the risk of exposing sensitive training data. Federated learning (FL) mitigates this risk by keeping training samples on local devices, while facing the following problems in privacy-preserving federated fine-tuning. (i) Recent studies show that adversaries can still infer private information in FL. (ii) LLM parameters are shared publicly during federated fine-tuning, while developers are often reluctant to disclose these parameters, posing further security challenges. (iii) Existing works focus on secure inference of LLMs but do not consider privacy-preserving fine-tuning. Inspired by the above problems, we propose PriFFT, a privacy-preserving federated fine-tuning mechanism, to protect both the model parameters and users' privacy. Due to considerable LLM parameters, we present hybrid secret sharing combining arithmetic secret sharing (ASS) and function secret sharing (FSS) to build secure operations and implement secure layers and activation for privacy-preserving fine-tuning. To improve the efficiency of privacy-preserving federated fine-tuning of LLMs, we optimize several secure computation protocols based on FSS, including reciprocal calculation, tensor products, natural exponentiation, softmax, sigmoid, hyperbolic tangent, and dropout. The hybrid secret sharing enables PriFFT to apply our optimized FSS protocols while combining ASS protocols to support complex computation without extra communication. The optimized protocols reduce execution time up to 62.5% and communication overhead up to 70.7% compared to existing protocols. Besides, PriFFT reduces execution time and communication overhead in privacy-preserving fine-tuning up to 59.1%$ and 77.0%$ without accuracy drop compared to the existing secret sharing methods.

cs.CR

Adaptive dose-response studies to establish proof-of-concept in learning-phase clinical trials

In learning-phase clinical trials in drug development, adaptive designs can be efficient and highly informative when used appropriately. In this article, we extend the multiple comparison procedures with modeling techniques (MCP-Mod) procedure with generalized multiple contrast tests (GMCTs) to two-stage adaptive designs for establishing proof-of-concept. The results of an interim analysis of first-stage data are used to adapt the candidate dose-response models and the dosages studied in the second stage. GMCTs are used in both stages to obtain stage-wise p-values, which are then combined to determine an overall p-value. An alternative approach is also considered that combines the t-statistics across stages, employing the conditional rejection probability (CRP) principle to preserve the Type I error probability. Simulation studies demonstrate that the adaptive designs are advantageous compared to the corresponding tests in a non-adaptive design if the selection of the candidate set of dose-response models is not well informed by evidence from preclinical and early-phase studies.

stat.ME