arXiv subjects

Shiyuan Zhao

Publications and source records attributed to Shiyuan Zhao.

4 recordsLinked to original sources

arXiv2026

ReBA-Pred-Net: Weakly-Supervised Regional Brain Age Prediction on MRI

Brain age has become a prominent biomarker of brain health. Yet most prior work targets whole brain age (WBA), a coarse paradigm that struggles to support tasks such as disease characterization and research on development and aging patterns, because relevant changes are typically region-selective rather than brain-wide. Therefore, robust regional brain age (ReBA) estimation is critical, yet a widely generalizable model has yet to be established. In this paper, we propose the Regional Brain Age Prediction Network (ReBA-Pred-Net), a Teacher-Student framework designed for fine-grained brain age estimation. The Teacher produces soft ReBA to guide the Student to yield reliable ReBA estimates with a clinical-prior consistency constraint (regions within the same function should change similarly). For rigorous evaluation, we introduce two indirect metrics: Healthy Control Similarity (HCS), which assesses statistical consistency by testing whether regional brain-age-gap (ReBA minus chronological age) distributions align between training and unseen HC; and Neuro Disease Correlation (NDC), which assesses factual consistency by checking whether clinically confirmed patients show elevated brain-age-gap in disease-associated regions. Experiments across multiple backbones demonstrate the statistical and factual validity of our method.

cs.CV↗

arXiv2025

PD-Diag-Net: Clinical-Priors guided Network on Brain MRI for Auxiliary Diagnosis of Parkinson's Disease

Parkinson's disease (PD) is a common neurodegenerative disorder that severely diminishes patients' quality of life. Its global prevalence has increased markedly in recent decades. Current diagnostic workflows are complex and heavily reliant on neurologists' expertise, often resulting in delays in early detection and missed opportunities for timely intervention. To address these issues, we propose an end-to-end automated diagnostic method for PD, termed PD-Diag-Net, which performs risk assessment and auxiliary diagnosis directly from raw MRI scans. This framework first introduces an MRI Pre-processing Module (MRI-Processor) to mitigate inter-subject and inter-scanner variability by flexibly integrating established medical imaging preprocessing tools. It then incorporates two forms of clinical prior knowledge: (1) Brain-Region-Relevance-Prior (Relevance-Prior), which specifies brain regions strongly associated with PD; and (2) Brain-Region-Aging-Prior (Aging-Prior), which reflects the accelerated aging typically observed in PD-associated regions. Building on these priors, we design two dedicated modules: the Relevance-Prior Guided Feature Aggregation Module (Aggregator), which guides the model to focus on PD-associated regions at the inter-subject level, and the Age-Prior Guided Diagnosis Module (Diagnoser), which leverages brain age gaps as auxiliary constraints at the intra-subject level to enhance diagnostic accuracy and clinical interpretability. Furthermore, we collected external test data from our collaborating hospital. Experimental results show that PD-Diag-Net achieves 86\% accuracy on external tests and over 96% accuracy in early-stage diagnosis, outperforming existing advanced methods by more than 20%.

cs.CV↗

arXiv2023

Unveiling the dynamical diversity of quantum dot lasers subject to optoelectronic feedback

This paper investigates experimentally and numerically the nonlinear dynamics of an epitaxial quantum dot laser on silicon subjected to optoelectronic feedback. Experimental results showcase a diverse range of dynamics, encompassing square wave patterns, quasi-chaotic states, and mixed waveforms exhibiting fast and slow oscillations. These measurements unequivocally demonstrate that quantum dot lasers on silicon readily and stably generate a more extensive repertoire of nonlinear dynamics compared to quantum well lasers. This pronounced sensitivity of quantum dot lasers to optoelectronic feedback represents a notable departure from their inherent insensitivity to optical feedback arising from reflections. Moreover, based on the Ikeda-like model, our simulations illustrate that the inherent characteristics of quantum dot lasers on silicon enable rapid and diverse dynamic transformations in response to optoelectronic feedback. The emergence of these exotic dynamics paves the way for further applications like integrated optical clocks, optical logic, and optical computing.

physics.optics↗

arXiv2023

Broadband amplitude squeezing in electrically driven quantum dot lasers

The generation of broadband squeezed states of light lies at the heart of high-speed continuous-variable quantum information. Traditionally, optical nonlinear interactions have been employed to produce quadrature-squeezed states. However, the harnessing of electrically pumped semiconductor lasers offers distinctive paradigms to achieve enhanced squeezing performance. We present evidence that quantum dot lasers enable the realization of broadband amplitude-squeezed states at room temperature across a wide frequency range, spanning from 3 GHz to 12 GHz. Our findings are corroborated by a comprehensive stochastic simulation in agreement with the experimental data.

physics.optics↗