arXiv subjects

Shizhuo Li

Publications and source records attributed to Shizhuo Li.

8 recordsLinked to original sources

arXiv2026

Vendor-Agnostic Joint Relaxometry and Myelin Water Fraction Mapping with B1 and Motion Correction

Obtaining consistent quantitative maps of myelin content and relaxation times across different sites and vendors is essential for advancing our understanding of brain development. Herein, we present a harmonized, vendor-agnostic magnetic resonance acquisition method designed for joint T1, T2, and myelin water fraction mapping, along with a method for rapid B1+ and B1- field estimation. We used our dictionary-based fitting and multi-compartment modeling for joint mapping of T1, T2 and myelin water fraction. Self-navigation-based retrospective motion correction was integrated with subspace reconstruction to track and correct rigid head motion during scanning, operating without the need for external hardware. Simulations, phantom and in vivo experiments confirmed the sensitivity and accuracy of the method, particularly for short T2 values corresponding to myelin, and demonstrated consistent performance across multiple scanner types. Coupled with the harmonized calibration scan, the proposed package offers a practical tool for multi-site, multi-vendor neuroimaging studies in both adult and pediatric populations.

physics.med-ph↗

arXiv2026

MWF-MIMOSA for efficient simultaneous relaxometry and myelin water fraction mapping

Quantitative magnetic resonance imaging (qMRI) provides improved sensitivity and specificity to tissue composition and pathological alterations compared with conventional contrast-weighted imaging. Among various qMRI biomarkers, myelin water imaging is of particular interest because myelin plays a central role in brain function and its alteration is closely associated with many neurological diseases. However, conventional myelin water fraction (MWF) mapping techniques are often limited by long scan times, low spatial resolution, reduced signal-to-noise ratio (SNR), and high specific absorption rate (SAR). Here, we propose MWF-MIMOSA for efficient simultaneous T1, T2, T2* mapping, magnetic susceptibility source separation, and MWF estimation. To achieve this, multi-contrast and multi-slice zero-shot self-supervised learning (MZS-SSL) was used to jointly reconstruct whole-brain complex-valued images. To improve computational efficiency of the parameter estimation step, a multilayer perceptron (MLP) was trained within the GACELLE GPU-accelerated parameter estimation framework to circumvent the computationally intensive Bloch simulation process, resulting in a >100-fold computational speed-up in MWF estimation. Numerical simulations were performed to evaluate the accuracy and precision of MWF-MIMOSA, and in-vivo results further demonstrated its robustness. Comparison with existing myelin water imaging methods showed that MWF-MIMOSA is highly correlated with established approaches, while providing complementary quantitative parameter maps at higher spatial resolution and with shorter scan times. Notably, simultaneous multi-parametric mapping was achieved in 5 min at 1 mm isotropic resolution, and in 10 min at 0.7 mm isotropic resolution. These results demonstrate the potential of MWF-MIMOSA for fast, high-resolution simultaneous relaxometry and myelin water imaging.

physics.med-ph↗

arXiv2026

Chat-Based Support Alone May Not Be Enough: Comparing Conversational and Embedded LLM Feedback for Mathematical Proof Learning

We evaluate GPTutor, an LLM-powered tutoring system for an undergraduate discrete mathematics course. It integrates two LLM-supported tools: a structured proof-review tool that provides embedded feedback on students' written proof attempts, and a chatbot for math questions. In a staggered-access study with 148 students, earlier access was associated with higher homework performance during the interval when only the experimental group could use the system, while we did not observe this performance increase transfer to exam scores. Usage logs show that students with lower self-efficacy and prior exam performance used both components more frequently. Session-level behavioral labels, produced by human coding and scaled using an automated classifier, characterize how students engaged with the chatbot (e.g., answer-seeking or help-seeking). In models controlling for prior performance and self-efficacy, higher chatbot usage and answer-seeking behavior were negatively associated with subsequent midterm performance, whereas proof-review usage showed no detectable independent association. Together, the findings suggest that chatbot-based support alone may not reliably support transfer to independent assessment of math proof-learning outcomes, whereas work-anchored, structured feedback appears less associated with reduced learning.

cs.HC↗

arXiv2025

Omni-QALAS: Optimized Multiparametric Imaging for Simultaneous T1, T2 and Myelin Water Mapping

Purpose: To improve the accuracy of multiparametric estimation, including myelin water fraction (MWF) quantification, and reduce scan time in 3D-QALAS by optimizing sequence parameters, using a self-supervised multilayer perceptron network. Methods: We jointly optimize flip angles, T2 preparation durations, and sequence gaps for T1 recovery using a self-supervised MLP trained to minimize a Cramer-Rao bound-based loss function, with explicit constraints on total scan time. The optimization targets white matter, gray matter, and myelin water tissues, and its performance was validated through simulation, phantom, and in vivo experiments. Results: Building on our previously proposed MWF-QALAS method for simultaneous MWF, T1, and T2 mapping, the optimized sequence reduces the number of readouts from six to five and achieves a scan time nearly one minute shorter, while also yielding higher T1 and T2 accuracy and improved MWF maps. This sequence enables simultaneous multiparametric quantification, including MWF, at 1 mm isotropic resolution within 3 minutes and 30 seconds. Conclusion: This study demonstrated that optimizing sequence parameters using a self-supervised MLP network improved T1, T2 and MWF estimation accuracy, while reducing scan time.

q-bio.QM↗

arXiv2025

Generative AI alone may not be enough: Evaluating AI Support for Learning Mathematical Proof

We evaluate the effectiveness of LLM-Tutor, a large language model (LLM)-powered tutoring system that combines an AI-based proof-review tutor for real-time feedback on proof-writing and a chatbot for mathematics-related queries. Our experiment, involving 148 students, demonstrated that the use of LLM-Tutor significantly improved homework performance compared to a control group without access to the system. However, its impact on exam performance and time spent on tasks was found to be insignificant. Mediation analysis revealed that students with lower self-efficacy tended to use the chatbot more frequently, which partially contributed to lower midterm scores. Furthermore, students with lower self-efficacy were more likely to engage frequently with the proof-review-AI-tutor, a usage pattern that positively contributed to higher final exam scores. Interviews with 19 students highlighted the accessibility of LLM-Tutor and its effectiveness in addressing learning needs, while also revealing limitations and concerns regarding potential over-reliance on the tool. Our results suggest that generative AI alone like chatbot may not suffice for comprehensive learning support, underscoring the need for iterative design improvements with learning sciences principles with generative AI educational tools like LLM-Tutor.

cs.HC↗

arXiv2025

Scalable twin-field quantum key distribution network enabled by adaptable architecture

Quantum key distribution (QKD) is a key application in quantum communication, enabling secure key exchange between parties using quantum states. Twin-field (TF) QKD offers a promising solution that surpasses the repeaterless limits, and its measurement-device-independent nature makes it suitable for star-type network architectures. In this work, we propose a scalable TF-QKD network with adaptable architecture, where users prepare quantum signals and send them to network nodes. These nodes use an optical switch to route the signals to multi-user measurement units, enabling secure key distribution among arbitrary users and adapting to complex connection demands of the network. A proof-of-principle demonstration with three users successfully achieved secure key sharing over simulated link losses of up to $30$ dB, with an average rate of $19.57$ bit/s. Additionally, simulations show that the proposed architecture can achieve a total secure key rate of $4.84 \times 10^{4}$ bit/s at $100$ km in a symmetric $32$-user network. This approach represents a significant advancement in the topology of untrusted-node QKD networks and holds promise for practical, large-scale applications in secure communication.

quant-ph↗

arXiv2025

SuiGPT MAD: Move AI Decompiler to Improve Transparency and Auditability on Non-Open-Source Blockchain Smart Contract

The vision of Web3 is to improve user control over data and assets, but one challenge that complicates this vision is the prevalence of non-transparent, scam-prone applications and vulnerable smart contracts that put Web3 users at risk. While code audits are one solution to this problem, the lack of smart contracts source code on many blockchain platforms, such as Sui, hinders the ease of auditing. A promising approach to this issue is the use of a decompiler to reverse-engineer smart contract bytecode. However, existing decompilers for Sui produce code that is difficult to understand and cannot be directly recompiled. To address this, we developed the SuiGPT Move AI Decompiler (MAD), a Large Language Model (LLM)-powered web application that decompiles smart contract bytecodes on Sui into logically correct, human-readable, and re-compilable source code with prompt engineering. Our evaluation shows that MAD's output successfully passes original unit tests and achieves a 73.33% recompilation success rate on real-world smart contracts. Additionally, newer models tend to deliver improved performance, suggesting that MAD's approach will become increasingly effective as LLMs continue to advance. In a user study involving 12 developers, we found that MAD significantly reduced the auditing workload compared to using traditional decompilers. Participants found MAD's outputs comparable to the original source code, improving accessibility for understanding and auditing non-open-source smart contracts. Through qualitative interviews with these developers and Web3 projects, we further discussed the strengths and concerns of MAD. MAD has practical implications for blockchain smart contract transparency, auditing, and education. It empowers users to easily and independently review and audit non-open-source smart contracts, fostering accountability and decentralization

cs.HC↗

arXiv2024

Refrence-Frame-Independent Quantum Key Distribution over 250 km of Optical Fiber

The reference-frame-independent quantum key distribution (RFI QKD) protocol enables QKD systems to function effectively despite slowly varying reference frames, offering a distinct advantage in practical scenarios, particularly in mobile platforms. In this study, we successfully distribute secure key bits over a 250-km optical fiber distance by developing an RFI QKD system with a repetition rate of 150 MHz. Benefiting from high repetition rate, we achieve a finite-key secret key rate of 49.65 bit/s at a distance of 200 km, which is more than three times higher than state-of-the-art systems. Our work dramatically extends the transmission distance and enhances the secret key rate of RFI QKD, significantly promoting its practical application.

quant-ph↗