arXiv subjects

Shujun Huang

Publications and source records attributed to Shujun Huang.

3 recordsLinked to original sources

arXiv2024

WeatherDepth: Curriculum Contrastive Learning for Self-Supervised Depth Estimation under Adverse Weather Conditions

Depth estimation models have shown promising performance on clear scenes but fail to generalize to adverse weather conditions due to illumination variations, weather particles, etc. In this paper, we propose WeatherDepth, a self-supervised robust depth estimation model with curriculum contrastive learning, to tackle performance degradation in complex weather conditions. Concretely, we first present a progressive curriculum learning scheme with three simple-to-complex curricula to gradually adapt the model from clear to relative adverse, and then to adverse weather scenes. It encourages the model to gradually grasp beneficial depth cues against the weather effect, yielding smoother and better domain adaption. Meanwhile, to prevent the model from forgetting previous curricula, we integrate contrastive learning into different curricula. By drawing reference knowledge from the previous course, our strategy establishes a depth consistency constraint between different courses toward robust depth estimation in diverse weather. Besides, to reduce manual intervention and better adapt to different models, we designed an adaptive curriculum scheduler to automatically search for the best timing for course switching. In the experiment, the proposed solution is proven to be easily incorporated into various architectures and demonstrates state-of-the-art (SoTA) performance on both synthetic and real weather datasets. Source code and data are available at \url{https://github.com/wangjiyuan9/WeatherDepth}.

cs.CV↗

arXiv2020

DTF: Deep Tensor Factorization for Predicting Anticancer Drug Synergy

Motivation: Combination therapies have been widely used to treat cancers. However, it is cost- and time-consuming to experimentally screen synergistic drug pairs due to the enormous number of possible drug combinations. Thus, computational methods have become an important way to predict and prioritize synergistic drug pairs. Results: We proposed a Deep Tensor Factorization (DTF) model, which integrated a tensor factorization method and a deep neural network (DNN), to predict drug synergy. The former extracts latent features from drug synergy information while the latter constructs a binary classifier to predict the drug synergy status. Compared to the tensor-based method, the DTF model performed better in predicting drug synergy. The area under the precision-recall curve (PR AUC) was 0.57 for DTF and 0.24 for the tensor method. We also compared the DTF model with DeepSynergy and logistic regression models and found that the DTF outperformed the logistic regression model and achieved almost the same performance as DeepSynergy using several typical metrics for the classification task. Applying the DTF model to predict missing entries in our drug-cell line tensor, we identified novel synergistic drug combinations for 10 cell lines from the 5 cancer types. A literature survey showed that some of these predicted drug synergies have been identified in vivo or in vitro. Thus, the DTF model could be valuable in silico tool for prioritizing novel synergistic drug combinations.

q-bio.QM↗

arXiv2019

Deep graph embedding for prioritizing synergistic anticancer drug combinations

Drug combinations are frequently used for the treatment of cancer patients in order to increase efficacy, decrease adverse side effects, or overcome drug resistance. Given the enormous number of drug combinations, it is cost- and time-consuming to screen all possible drug pairs experimentally. Currently, it has not been fully explored to integrate multiple networks to predict synergistic drug combinations using recently developed deep learning technologies. In this study, we proposed a Graph Convolutional Network (GCN) model to predict synergistic drug combinations in particular cancer cell lines. Specifically, the GCN method used a convolutional neural network model to do heterogeneous graph embedding, and thus solved a link prediction task. The graph in this study was a multimodal graph, which was constructed by integrating the drug-drug combination, drug-protein interaction, and protein-protein interaction networks. We found that the GCN model was able to correctly predict cell line-specific synergistic drug combinations from a large heterogonous network. The majority (30) of the 39 cell line-specific models show an area under the receiver operational characteristic curve (AUC) larger than 0.80, resulting in a mean AUC of 0.84. Moreover, we conducted an in-depth literature survey to investigate the top predicted drug combinations in specific cancer cell lines and found that many of them have been found to show synergistic antitumor activity against the same or other cancers in vitro or in vivo. Taken together, the results indicate that our study provides a promising way to better predict and optimize synergistic drug pairs in silico.

q-bio.MN↗