Shuliang Zhao | Searcharxiv

arXiv2025

ALEX:A Light Editing-knowledge Extractor

The static nature of knowledge within Large Language Models (LLMs) makes it difficult for them to adapt to evolving information, rendering knowledge editing a critical task. However, existing methods struggle with challenges of scalability and retrieval efficiency, particularly when handling complex, multi-hop questions that require multi-step reasoning. To address these challenges, this paper introduces ALEX (A Light Editing-knowledge Extractor), a lightweight knowledge editing framework. The core innovation of ALEX is its hierarchical memory architecture, which organizes knowledge updates (edits) into semantic clusters. This design fundamentally reduces retrieval complexity from a linear O(N) to a highly scalable O(K+N/C). Furthermore, the framework integrates an Inferential Query Synthesis (IQS) module to bridge the semantic gap between queries and facts , and a Dynamic Evidence Adjudication (DEA) engine that executes an efficient two-stage retrieval process. Experiments on the MQUAKE benchmark demonstrate that ALEX significantly improves both the accuracy of multi-hop answers (MultiHop-ACC) and the reliability of reasoning paths (HopWise-ACC). It also reduces the required search space by over 80% , presenting a promising path toward building scalable, efficient, and accurate knowledge editing systems.

cs.AI↗

arXiv2022

SS-GNN: A Simple-Structured Graph Neural Network for Affinity Prediction

Efficient and effective drug-target binding affinity (DTBA) prediction is a challenging task due to the limited computational resources in practical applications and is a crucial basis for drug screening. Inspired by the good representation ability of graph neural networks (GNNs), we propose a simple-structured GNN model named SS-GNN to accurately predict DTBA. By constructing a single undirected graph based on a distance threshold to represent protein-ligand interactions, the scale of the graph data is greatly reduced. Moreover, ignoring covalent bonds in the protein further reduces the computational cost of the model. The GNN-MLP module takes the latent feature extraction of atoms and edges in the graph as two mutually independent processes. We also develop an edge-based atom-pair feature aggregation method to represent complex interactions and a graph pooling-based method to predict the binding affinity of the complex. We achieve state-of-the-art prediction performance using a simple model (with only 0.6M parameters) without introducing complicated geometric feature descriptions. SS-GNN achieves Pearson's Rp=0.853 on the PDBbind v2016 core set, outperforming state-of-the-art GNN-based methods by 5.2%. Moreover, the simplified model structure and concise data processing procedure improve the prediction efficiency of the model. For a typical protein-ligand complex, affinity prediction takes only 0.2 ms. All codes are freely accessible at https://github.com/xianyuco/SS-GNN.

q-bio.BM↗