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Shunping Huang

Publications and source records attributed to Shunping Huang.

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CALM: A Framework for Continuous, Adaptive, and LLM-Mediated Anomaly Detection in Time-Series Streams

The detection of anomalies in non-stationary time-series streams is a critical but challenging task across numerous industrial and scientific domains. Traditional models, trained offline, suffer significant performance degradation when faced with concept drift, where the underlying statistical properties of the data change over time. This paper introduces CALM (Continuous, Adaptive, and LLM-Mediated), a novel, end-to-end framework for real-time anomaly detection designed to address this challenge. CALM is built on the Apache Beam distributed processing framework and leverages the TimesFm foundation model for forecasting-based anomaly detection. The framework's novelty lies in two core contributions. First, it implements a closed-loop, continuous fine-tuning mechanism that allows the anomaly detection model to adapt to evolving data patterns in near real-time. Second, it introduces an LLM-as-a-Judge component, a Large Language Model that provides semantic, context-aware judgments on detected anomalies to curate a high-quality training dataset, deciding whether an anomaly represents transient noise or a meaningful pattern shift. We evaluate CALM on the comprehensive TSB-UAD benchmark. Our results demonstrate that the continuously fine-tuned model improves the ROC AUC score in most datasets compared to the static, pre-trained base model, validating the efficacy of our adaptive, LLM-guided approach to maintaining high-performance anomaly detection in dynamic streaming environments.

cs.LG

IsoDOT Detects Differential RNA-isoform Expression/Usage with respect to a Categorical or Continuous Covariate with High Sensitivity and Specificity

We have developed a statistical method named IsoDOT to assess differential isoform expression (DIE) and differential isoform usage (DIU) using RNA-seq data. Here isoform usage refers to relative isoform expression given the total expression of the corresponding gene. IsoDOT performs two tasks that cannot be accomplished by existing methods: to test DIE/DIU with respect to a continuous covariate, and to test DIE/DIU for one case versus one control. The latter task is not an uncommon situation in practice, e.g., comparing paternal and maternal allele of one individual or comparing tumor and normal sample of one cancer patient. Simulation studies demonstrate the high sensitivity and specificity of IsoDOT. We apply IsoDOT to study the effects of haloperidol treatment on mouse transcriptome and identify a group of genes whose isoform usages respond to haloperidol treatment.

stat.AP