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Siddhant Garg

Publications and source records attributed to Siddhant Garg.

At least 19 recordsLinked to original sources

CLARA: Clarification of Language Ambiguity through Result Analysis for Natural-Language Cancer Genomics Queries

A natural language interface can be used to make cancer genomics databases easier to use, but even if a question is perfectly fluent, its scientific meaning can be ambiguous. We propose CLARA, a framework that represents a question as a typed scientific query specification, considers a few possible interpretations, executes them, and asks for clarification when the estimates diverge. CLARA was assessed on mutation-prevalence contrasts among eight TCGA PanCancer Atlas cohorts and a 30-gene panel. This benchmark consisted of 330 unique executable contrasts varying in mutation scope, assay denominator, and sample context; 115 contrasts were result-sensitive and 215 were result-stable, per the preregistered definition of relative divergence greater than 0.10 or absolute divergence greater than 5 percentage points. An independently implemented pandas execution engine perfectly replicated all 660 results from the SQLite engine. In a separate 120-question LLM-generated, manually vetted language stress test, CLARA recognized all 60 result-sensitive contrasts and needlessly clarified 13 of 60 stable contrasts (accuracy 89.2%, sensitivity/recall 100%, specificity 78.3%). Standalone machine learning had superior overall accuracy (97.5%) but missed one critical contrast. This demonstrates that downstream execution can distinguish consequential from inconsequential ambiguity and reveal an explicit trade-off between safety and burden.

q-bio.GN

Evaluating Conformal Reliability of Pathway-Level Transcriptomic Signatures Under Cross-Cohort Shift in Sepsis Mortality Prediction

Blood transcriptomic profiling enables prognostic modeling by capturing the host immune response at the molecular level. Yet, the within-cohort evaluation strategies employed by many transcriptomic models inadequately reflect deployment across independent hospitals. Outside deployment scenarios introduce a cohort shift that can substantially degrade predictive performance and reliability of uncertainty estimates. We present a framework for evaluating transcriptomic sepsis mortality prediction under realistic cross-cohort deployment, systematically comparing gene-level, pathway-level and hybrid molecular representations. Four publicly available whole-blood transcriptomic cohorts consisting of 936 patients and 248 mortality events were harmonized into a shared 7,660-gene feature space and evaluated under leave-one-cohort-out validation using logistic regression, random forests, XGBoost and LightGBM. Beyond AUROC and AUPRC, model behavior was evaluated via conformal prediction, calibration analysis, selective prediction and the proposed Pathway Stability Index. Gene-level and hybrid representations were found to generally achieve the strongest discriminative performance, whereas pathway-level representations exhibited greater robustness across model families, more reliable uncertainty behavior under cross-cohort shift and stable molecular signatures enriched for immune and host-defense processes identified through Gene Ontology and KEGG enrichment analyses. These findings demonstrate that molecular representation influences not only predictive discrimination but also calibration, uncertainty reliability, biological coherence and transferability under external validation.

q-bio.GN

Memory-QA: Answering Recall Questions Based on Multimodal Memories

We introduce Memory-QA, a novel real-world task that involves answering recall questions about visual content from previously stored multimodal memories. This task poses unique challenges, including the creation of task-oriented memories, the effective utilization of temporal and location information within memories, and the ability to draw upon multiple memories to answer a recall question. To address these challenges, we propose a comprehensive pipeline, Pensieve, integrating memory-specific augmentation, time- and location-aware multi-signal retrieval, and multi-memory QA fine-tuning. We created a multimodal benchmark to illustrate various real challenges in this task, and show the superior performance of Pensieve over state-of-the-art solutions (up to 14% on QA accuracy).

cs.AI

ArchXBench: A Complex Digital Systems Benchmark Suite for LLM Driven RTL Synthesis

Modern SoC datapaths include deeply pipelined, domain-specific accelerators, but their RTL implementation and verification are still mostly done by hand. While large language models (LLMs) exhibit advanced code-generation abilities for programming languages like Python, their application to Verilog-like RTL remains in its nascent stage. This is reflected in the simple arithmetic and control circuits currently used to evaluate generative capabilities in existing benchmarks. In this paper, we introduce ArchXBench, a six-level benchmark suite that encompasses complex arithmetic circuits and other advanced digital subsystems drawn from domains such as cryptography, image processing, machine learning, and signal processing. Architecturally, some of these designs are purely combinational, others are multi-cycle or pipelined, and many require hierarchical composition of modules. For each benchmark, we provide a problem description, design specification, and testbench, enabling rapid research in the area of LLM-driven agentic approaches for complex digital systems design. Using zero-shot prompting with Claude Sonnet 4, GPT 4.1, o4-mini-high, and DeepSeek R1 under a pass@5 criterion, we observed that o4-mini-high successfully solves the largest number of benchmarks, 16 out of 30, spanning Levels 1, 2, and 3. From Level 4 onward, however, all models consistently fail, highlighting a clear gap in the capabilities of current state-of-the-art LLMs and prompting/agentic approaches.

cs.AR

Measuring Retrieval Complexity in Question Answering Systems

In this paper, we investigate which questions are challenging for retrieval-based Question Answering (QA). We (i) propose retrieval complexity (RC), a novel metric conditioned on the completeness of retrieved documents, which measures the difficulty of answering questions, and (ii) propose an unsupervised pipeline to measure RC given an arbitrary retrieval system. Our proposed pipeline measures RC more accurately than alternative estimators, including LLMs, on six challenging QA benchmarks. Further investigation reveals that RC scores strongly correlate with both QA performance and expert judgment across five of the six studied benchmarks, indicating that RC is an effective measure of question difficulty. Subsequent categorization of high-RC questions shows that they span a broad set of question shapes, including multi-hop, compositional, and temporal QA, indicating that RC scores can categorize a new subset of complex questions. Our system can also have a major impact on retrieval-based systems by helping to identify more challenging questions on existing datasets.

cs.CL

SQUARE: Automatic Question Answering Evaluation using Multiple Positive and Negative References

Evaluation of QA systems is very challenging and expensive, with the most reliable approach being human annotations of correctness of answers for questions. Recent works (AVA, BEM) have shown that transformer LM encoder based similarity metrics transfer well for QA evaluation, but they are limited by the usage of a single correct reference answer. We propose a new evaluation metric: SQuArE (Sentence-level QUestion AnsweRing Evaluation), using multiple reference answers (combining multiple correct and incorrect references) for sentence-form QA. We evaluate SQuArE on both sentence-level extractive (Answer Selection) and generative (GenQA) QA systems, across multiple academic and industrial datasets, and show that it outperforms previous baselines and obtains the highest correlation with human annotations.

cs.CL

Cross-Shape Attention for Part Segmentation of 3D Point Clouds

We present a deep learning method that propagates point-wise feature representations across shapes within a collection for the purpose of 3D shape segmentation. We propose a cross-shape attention mechanism to enable interactions between a shape's point-wise features and those of other shapes. The mechanism assesses both the degree of interaction between points and also mediates feature propagation across shapes, improving the accuracy and consistency of the resulting point-wise feature representations for shape segmentation. Our method also proposes a shape retrieval measure to select suitable shapes for cross-shape attention operations for each test shape. Our experiments demonstrate that our approach yields state-of-the-art results in the popular PartNet dataset.

cs.CV

Learning Answer Generation using Supervision from Automatic Question Answering Evaluators

Recent studies show that sentence-level extractive QA, i.e., based on Answer Sentence Selection (AS2), is outperformed by Generation-based QA (GenQA) models, which generate answers using the top-k answer sentences ranked by AS2 models (a la retrieval-augmented generation style). In this paper, we propose a novel training paradigm for GenQA using supervision from automatic QA evaluation models (GAVA). Specifically, we propose three strategies to transfer knowledge from these QA evaluation models to a GenQA model: (i) augmenting training data with answers generated by the GenQA model and labelled by GAVA (either statically, before training, or (ii) dynamically, at every training epoch); and (iii) using the GAVA score for weighting the generator loss during the learning of the GenQA model. We evaluate our proposed methods on two academic and one industrial dataset, obtaining a significant improvement in answering accuracy over the previous state of the art.

cs.CL

Context-Aware Transformer Pre-Training for Answer Sentence Selection

Answer Sentence Selection (AS2) is a core component for building an accurate Question Answering pipeline. AS2 models rank a set of candidate sentences based on how likely they answer a given question. The state of the art in AS2 exploits pre-trained transformers by transferring them on large annotated datasets, while using local contextual information around the candidate sentence. In this paper, we propose three pre-training objectives designed to mimic the downstream fine-tuning task of contextual AS2. This allows for specializing LMs when fine-tuning for contextual AS2. Our experiments on three public and two large-scale industrial datasets show that our pre-training approaches (applied to RoBERTa and ELECTRA) can improve baseline contextual AS2 accuracy by up to 8% on some datasets.

cs.CL

Structured Pruning for Multi-Task Deep Neural Networks

Although multi-task deep neural network (DNN) models have computation and storage benefits over individual single-task DNN models, they can be further optimized via model compression. Numerous structured pruning methods are already developed that can readily achieve speedups in single-task models, but the pruning of multi-task networks has not yet been extensively studied. In this work, we investigate the effectiveness of structured pruning on multi-task models. We use an existing single-task filter pruning criterion and also introduce an MTL-based filter pruning criterion for estimating the filter importance scores. We prune the model using an iterative pruning strategy with both pruning methods. We show that, with careful hyper-parameter tuning, architectures obtained from different pruning methods do not have significant differences in their performances across tasks when the number of parameters is similar. We also show that iterative structure pruning may not be the best way to achieve a well-performing pruned model because, at extreme pruning levels, there is a high drop in performance across all tasks. But when the same models are randomly initialized and re-trained, they show better results.

cs.LG

Knowledge Transfer from Answer Ranking to Answer Generation

Recent studies show that Question Answering (QA) based on Answer Sentence Selection (AS2) can be improved by generating an improved answer from the top-k ranked answer sentences (termed GenQA). This allows for synthesizing the information from multiple candidates into a concise, natural-sounding answer. However, creating large-scale supervised training data for GenQA models is very challenging. In this paper, we propose to train a GenQA model by transferring knowledge from a trained AS2 model, to overcome the aforementioned issue. First, we use an AS2 model to produce a ranking over answer candidates for a set of questions. Then, we use the top ranked candidate as the generation target, and the next k top ranked candidates as context for training a GenQA model. We also propose to use the AS2 model prediction scores for loss weighting and score-conditioned input/output shaping, to aid the knowledge transfer. Our evaluation on three public and one large industrial datasets demonstrates the superiority of our approach over the AS2 baseline, and GenQA trained using supervised data.

cs.CL

Pre-training Transformer Models with Sentence-Level Objectives for Answer Sentence Selection

An important task for designing QA systems is answer sentence selection (AS2): selecting the sentence containing (or constituting) the answer to a question from a set of retrieved relevant documents. In this paper, we propose three novel sentence-level transformer pre-training objectives that incorporate paragraph-level semantics within and across documents, to improve the performance of transformers for AS2, and mitigate the requirement of large labeled datasets. Specifically, the model is tasked to predict whether: (i) two sentences are extracted from the same paragraph, (ii) a given sentence is extracted from a given paragraph, and (iii) two paragraphs are extracted from the same document. Our experiments on three public and one industrial AS2 datasets demonstrate the empirical superiority of our pre-trained transformers over baseline models such as RoBERTa and ELECTRA for AS2.

cs.CL

SeRP: Self-Supervised Representation Learning Using Perturbed Point Clouds

We present SeRP, a framework for Self-Supervised Learning of 3D point clouds. SeRP consists of encoder-decoder architecture that takes perturbed or corrupted point clouds as inputs and aims to reconstruct the original point cloud without corruption. The encoder learns the high-level latent representations of the points clouds in a low-dimensional subspace and recovers the original structure. In this work, we have used Transformers and PointNet-based Autoencoders. The proposed framework also addresses some of the limitations of Transformers-based Masked Autoencoders which are prone to leakage of location information and uneven information density. We trained our models on the complete ShapeNet dataset and evaluated them on ModelNet40 as a downstream classification task. We have shown that the pretrained models achieved 0.5-1% higher classification accuracies than the networks trained from scratch. Furthermore, we also proposed VASP: Vector-Quantized Autoencoder for Self-supervised Representation Learning for Point Clouds that employs Vector-Quantization for discrete representation learning for Transformer-based autoencoders.

cs.CV

Attentive Walk-Aggregating Graph Neural Networks

Graph neural networks (GNNs) have been shown to possess strong representation power, which can be exploited for downstream prediction tasks on graph-structured data, such as molecules and social networks. They typically learn representations by aggregating information from the $K$-hop neighborhood of individual vertices or from the enumerated walks in the graph. Prior studies have demonstrated the effectiveness of incorporating weighting schemes into GNNs; however, this has been primarily limited to $K$-hop neighborhood GNNs so far. In this paper, we aim to design an algorithm incorporating weighting schemes into walk-aggregating GNNs and analyze their effect. We propose a novel GNN model, called AWARE, that aggregates information about the walks in the graph using attention schemes. This leads to an end-to-end supervised learning method for graph-level prediction tasks in the standard setting where the input is the adjacency and vertex information of a graph, and the output is a predicted label for the graph. We then perform theoretical, empirical, and interpretability analyses of AWARE. Our theoretical analysis in a simplified setting identifies successful conditions for provable guarantees, demonstrating how the graph information is encoded in the representation, and how the weighting schemes in AWARE affect the representation and learning performance. Our experiments demonstrate the strong performance of AWARE in graph-level prediction tasks in the standard setting in the domains of molecular property prediction and social networks. Lastly, our interpretation study illustrates that AWARE can successfully capture the important substructures of the input graph. The code is available on $\href{https://github.com/mehmetfdemirel/aware}{GitHub}$.

cs.LG

Paragraph-based Transformer Pre-training for Multi-Sentence Inference

Inference tasks such as answer sentence selection (AS2) or fact verification are typically solved by fine-tuning transformer-based models as individual sentence-pair classifiers. Recent studies show that these tasks benefit from modeling dependencies across multiple candidate sentences jointly. In this paper, we first show that popular pre-trained transformers perform poorly when used for fine-tuning on multi-candidate inference tasks. We then propose a new pre-training objective that models the paragraph-level semantics across multiple input sentences. Our evaluation on three AS2 and one fact verification datasets demonstrates the superiority of our pre-training technique over the traditional ones for transformers used as joint models for multi-candidate inference tasks, as well as when used as cross-encoders for sentence-pair formulations of these tasks. Our code and pre-trained models are released at https://github.com/amazon-research/wqa-multi-sentence-inference .

cs.CL

Self-Labeling Refinement for Robust Representation Learning with Bootstrap Your Own Latent

In this work, we have worked towards two major goals. Firstly, we have investigated the importance of Batch Normalisation (BN) layers in a non-contrastive representation learning framework called Bootstrap Your Own Latent (BYOL). We conducted several experiments to conclude that BN layers are not necessary for representation learning in BYOL. Moreover, BYOL only learns from the positive pairs of images but ignores other semantically similar images in the same input batch. For the second goal, we have introduced two new loss functions to determine the semantically similar pairs in the same input batch of images and reduce the distance between their representations. These loss functions are Cross-Cosine Similarity Loss (CCSL) and Cross-Sigmoid Similarity Loss (CSSL). Using the proposed loss functions, we are able to surpass the performance of Vanilla BYOL (71.04%) by training the BYOL framework using CCSL loss (76.87%) on the STL10 dataset. BYOL trained using CSSL loss performs comparably with Vanilla BYOL.

cs.CV

Towards Robustness to Label Noise in Text Classification via Noise Modeling

Large datasets in NLP suffer from noisy labels, due to erroneous automatic and human annotation procedures. We study the problem of text classification with label noise, and aim to capture this noise through an auxiliary noise model over the classifier. We first assign a probability score to each training sample of having a noisy label, through a beta mixture model fitted on the losses at an early epoch of training. Then, we use this score to selectively guide the learning of the noise model and classifier. Our empirical evaluation on two text classification tasks shows that our approach can improve over the baseline accuracy, and prevent over-fitting to the noise.

cs.CL

A Simple Approach to Image Tilt Correction with Self-Attention MobileNet for Smartphones

The main contributions of our work are two-fold. First, we present a Self-Attention MobileNet, called SA-MobileNet Network that can model long-range dependencies between the image features instead of processing the local region as done by standard convolutional kernels. SA-MobileNet contains self-attention modules integrated with the inverted bottleneck blocks of the MobileNetV3 model which results in modeling of both channel-wise attention and spatial attention of the image features and at the same time introduce a novel self-attention architecture for low-resource devices. Secondly, we propose a novel training pipeline for the task of image tilt detection. We treat this problem in a multi-label scenario where we predict multiple angles for a tilted input image in a narrow interval of range 1-2 degrees, depending on the dataset used. This process induces an implicit correlation between labels without any computational overhead of the second or higher-order methods in multi-label learning. With the combination of our novel approach and the architecture, we present state-of-the-art results on detecting the image tilt angle on mobile devices as compared to the MobileNetV3 model. Finally, we establish that SA-MobileNet is more accurate than MobileNetV3 on SUN397, NYU-V1, and ADE20K datasets by 6.42%, 10.51%, and 9.09% points respectively, and faster by at least 4 milliseconds on Snapdragon 750 Octa-core.

cs.CV