SearcharxivSearch

arXiv subjects

Silvano Coletti

Publications and source records attributed to Silvano Coletti.

2 recordsLinked to original sources

Graph Vector Field: A Unified Framework for Multimodal Health Risk Assessment from Heterogeneous Wearable and Environmental Data Streams

Digital health research has advanced dynamic graph-based disease models, topological learning on simplicial complexes, and multimodal mixture-of-experts architectures, but these strands remain largely disconnected. We propose Graph Vector Field (GVF), a framework that models health risk as a vector-valued field on time-varying simplicial complexes, coupling discrete differential-geometric operators with modality-structured mixture-of-experts. Risk is represented as a vector-valued cochain whose evolution is parameterised with Hodge Laplacians and discrete exterior calculus operators, yielding a Helmholtz-Hodge decomposition into potential-driven (exact), circulation-like (coexact), and topologically constrained (harmonic) components linked to interpretable propagation, cyclic, and persistent risk mechanisms. Multimodal inputs from wearable sensors, behavioural/environmental context, and clinical/genomic data are incorporated through a bundle-structured mixture-of-experts in which modality-specific latent spaces are attached as fibres to the base complex. This separates modality-specific from shared contributions and offers a principled route toward modality-level identifiability. GVF integrates geometric dynamical systems, higher-order topology (enforced indirectly via geometric regularisation and Hodge decomposition), and structured multimodal fusion into a single framework for interpretable, modality-resolved risk modelling. This paper develops the mathematical foundations, architectural design, and formal guarantees; empirical validation is the subject of ongoing work.

cs.LG

Tunable and Portable Extreme-Scale Drug Discovery Platform at Exascale: the LIGATE Approach

Today digital revolution is having a dramatic impact on the pharmaceutical industry and the entire healthcare system. The implementation of machine learning, extreme-scale computer simulations, and big data analytics in the drug design and development process offers an excellent opportunity to lower the risk of investment and reduce the time to the patient. Within the LIGATE project, we aim to integrate, extend, and co-design best-in-class European components to design Computer-Aided Drug Design (CADD) solutions exploiting today's high-end supercomputers and tomorrow's Exascale resources, fostering European competitiveness in the field. The proposed LIGATE solution is a fully integrated workflow that enables to deliver the result of a virtual screening campaign for drug discovery with the highest speed along with the highest accuracy. The full automation of the solution and the possibility to run it on multiple supercomputing centers at once permit to run an extreme scale in silico drug discovery campaign in few days to respond promptly for example to a worldwide pandemic crisis.

cs.DC