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Simon M. S. Lo

Publications and source records attributed to Simon M. S. Lo.

3 recordsLinked to original sources

Nonparametric regression with dependent censoring or competing risks

Single-index models or time-to-event models are frequently applied in empirical research. These models are non-identifiable in presence of unknown (dependent) censoring or competing risks and do not give informative results in empirical analysis unless rather strong, non-testable restrictions hold. Little is known, whether the known robustness properties of the single-index model carry over to models with dependent censoring or competing risks. This paper shows that the ratio of partial covariate effects on the margins is identifiable in nonparametric models with unknown dependent censoring or nonparametric competing risks models with nonparametric dependence structure, provided an exclusion restriction holds. Commonly used (semi)parametric models for the margin and independent censoring, such as Cox proportional hazards, accelerated failure time or proportional odds models, can be used to obtain relative covariate effects despite their misspecified censoring mechanism. Several nonparametric estimators for the general model are introduced and their numerical properties are studied.

stat.ME↗

On the implications of proportional hazards assumptions for competing risks modelling

The assumption of hazard rates being proportional in covariates is widely made in empirical research and extensive research has been done to develop tests of its validity. This paper does not contribute on this end. Instead, it gives new insights on the implications of proportional hazards (PH) modelling in competing risks models. It is shown that the use of a PH model for the cause-specific hazards or subdistribution hazards can strongly restrict the class of copulas and marginal hazards for being compatible with a competing risks model. The empirical researcher should be aware that working with these models can be so restrictive that only degenerate or independent risks models are compatible. Numerical results confirm that estimates of cause-specific hazards models are not informative about patterns in the data generating process.

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A single risk approach to the semiparametric copula competing risks model

A typical situation in competing risks analysis is that the researcher is only interested in a subset of risks. This paper considers a depending competing risks model with the distribution of one risk being a parametric or semi-parametric model, while the model for the other risks being unknown. Identifiability is shown for popular classes of parametric models and the semiparametric proportional hazards model. The identifiability of the parametric models does not require a covariate, while the semiparametric model requires at least one. Estimation approaches are suggested which are shown to be $\sqrt{n}$-consistent. Applicability and attractive finite sample performance are demonstrated with the help of simulations and data examples.

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