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Siting Li

Publications and source records attributed to Siting Li.

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Studying Image Tokenizers as Visual Languages in Unified Multimodal Models

Image tokenizers define the ``visual language'' of unified multimodal models, yet are commonly studied through isolated metrics or generation-/understanding-only evaluations. These evaluations do not fully capture how visual tokens behave when modeled jointly with text. We build a controlled pure-autoregressive testbed and track task-specific validation losses during multimodal continual pretraining across text, image, text-to-image (T2I), and image-to-text (I2T) prediction. We examine how these losses scale and relate to downstream performance, then use them to study multimodal learnability---how well image and text tokens are jointly modeled---and tokenizer design. We find that (1) losses should be analyzed by task, since they exhibit distinct scaling behavior and rank tokenizers differently. (2) The loss--performance relationship depends on the predicted token space: for a fixed tokenizer, T2I and I2T losses correlate with generation quality, but across tokenizers, the T2I loss--performance relationship shifts with the image-token space, whereas I2T loss, computed over a shared text vocabulary, provides a more consistent signal. I2T loss also correlates with both generation and visual understanding performance after supervised finetuning. Using losses as a lens, we show that (3) better reconstruction does not necessarily yield lower task-specific losses or stronger downstream performance, and that (4) image tokenizer choice can affect text modeling under joint optimization. As case studies, we revisit three tokenizer design axes---the discriminator, semantic supervision, and vocabulary size---to examine their effects on joint modeling and downstream performance. Together, our testbed offers a complementary perspective on image tokenizers as visual languages, highlighting their interplay with text in joint multimodal training.

cs.CV

Apodex Discovery: Reality Benchmarks and Environments for Evaluating and Building Discoverative Artificial Intelligence

Apollo did not reach the Moon merely because its engineers could solve difficult equations. It succeeded by turning a distant ambition into a mission architecture of explicit objectives, simulation, verification, and repeated correction. AI now faces a similar transition: frontier models can solve difficult tasks once the problem, tools, and success criteria are specified, yet consequential real-world challenges rarely arrive in an executable or verifiable form. We introduce Apodex Discovery, a framework for building and evaluating discoverative AI through the heavy-duty solver, a system comprising a foundation model, harness, tools, and control policies that pursues extended, stateful, verifiable investigations. It has three core components. First, a problem-scouting process surveyed 561 industries across 16 sectors, assembled 423 high-value real-world problems, and selected 20 for the initial release. Second, a common environment-task-episode abstraction provides data, tools, constraints, feedback, trajectory recording, and verification of intermediate artifacts and final submissions. Third, HDS6 evaluates Tools, Repair, Alternatives, Coherence, Evidence, and Scope independently of final-task success. In AAV capsid design, Apodex surpassed the published state of the art by 7% across viability, tropism, structure prediction, and generative design. In drug repurposing and reformulation, a task-specific biomedical environment improved the mean normalized prediction score of GPT-5.5 and GPT-5.6-sol by 2.5 and 7.6 points over the same closed-book backbone. Controlled ablations show that the fixed TRACES episode interface enables attribution of performance differences to specific solver components. Apodex Discovery moves AI evaluation beyond predefined benchmarks toward verifiable investigations aimed at genuine discovery.

cs.AI

HiST: A Hierarchical Sparse Transformer for Cross-Modal Spatial Transcriptomics Modeling

Spatial transcriptomics (ST) links gene expression with tissue morphology but remains expensive and low-throughput, motivating surrogates that infer expression from routine histology. Whole-slide H&E-to-ST inference pairs a gigapixel image with gene measurements at a sparse, irregular set of locations, making multiscale modeling challenging without incurring dense-grid overhead or quadratic token mixing. We propose HiST, a hierarchical sparse transformer that treats measured locations as a lattice-indexed sparse field and builds a dyadic encoder--decoder directly on the active tissue footprint. HiST combines sparse window attention for local geometric correspondence with resolution-changing operators for rapid multiscale context integration. For a fixed window size, the dominant runtime and memory scale with the number of observed locations rather than the dense slide area. To mitigate slide-specific acquisition variation, HiST adds a bottlenecked global conditioning pathway via a \emph{slide calibration token} that summarizes slide-level context and conditions local representations. On a multi-organ benchmark spanning diverse tissues and acquisition sources, HiST improves predictive performance over recent baselines while reducing runtime and peak memory.

cs.CV

Exploiting Label-Independent Regularization from Spatial Dependencies for Whole Slide Image Analysis

Whole slide images, with their gigapixel-scale panoramas of tissue samples, are pivotal for precise disease diagnosis. However, their analysis is hindered by immense data size and scarce annotations. Existing MIL methods face challenges due to the fundamental imbalance where a single bag-level label must guide the learning of numerous patch-level features. This sparse supervision makes it difficult to reliably identify discriminative patches during training, leading to unstable optimization and suboptimal solutions. We propose a spatially regularized MIL framework that leverages inherent spatial relationships among patch features as label-independent regularization signals. Our approach learns a shared representation space by jointly optimizing feature-induced spatial reconstruction and label-guided classification objectives, enforcing consistency between intrinsic structural patterns and supervisory signals. Experimental results on multiple public datasets demonstrate significant improvements over state-of-the-art methods, offering a promising direction.

cs.CV

RLVE: Scaling Up Reinforcement Learning for Language Models with Adaptive Verifiable Environments

We introduce Reinforcement Learning (RL) with Adaptive Verifiable Environments (RLVE), an approach using verifiable environments that procedurally generate problems and provide algorithmically verifiable rewards, to scale up RL for language models (LMs). RLVE enables each verifiable environment to dynamically adapt its problem difficulty distribution to the policy model's capabilities as training progresses. In contrast, static data distributions often lead to vanishing learning signals when problems are either too easy or too hard for the policy. To implement RLVE, we create RLVE-Gym, a large-scale suite of 400 verifiable environments carefully developed through manual environment engineering. Using RLVE-Gym, we show that environment scaling, i.e., expanding the collection of training environments, consistently improves generalizable reasoning capabilities. RLVE with joint training across all 400 environments in RLVE-Gym yields a 3.37% absolute average improvement across six reasoning benchmarks, starting from one of the strongest 1.5B reasoning LMs. By comparison, continuing this LM's original RL training yields only a 0.49% average absolute gain despite using over 3x more compute. We release our code publicly.

cs.CL

Highlighting What Matters: Promptable Embeddings for Attribute-Focused Image Retrieval

While an image is worth more than a thousand words, only a few provide crucial information for a given task and thus should be focused on. In light of this, ideal text-to-image (T2I) retrievers should prioritize specific visual attributes relevant to queries. To evaluate current retrievers on handling attribute-focused queries, we build COCO-Facet, a COCO-based benchmark with 9,112 queries about diverse attributes of interest. We find that CLIP-like retrievers, which are widely adopted due to their efficiency and zero-shot ability, have poor and imbalanced performance, possibly because their image embeddings focus on global semantics and subjects while leaving out other details. Notably, we reveal that even recent Multimodal Large Language Model (MLLM)-based, stronger retrievers with a larger output dimension struggle with this limitation. Hence, we hypothesize that retrieving with general image embeddings is suboptimal for performing such queries. As a solution, we propose to use promptable image embeddings enabled by these multimodal retrievers, which boost performance by highlighting required attributes. Our pipeline for deriving such embeddings generalizes across query types, image pools, and base retriever architectures. To enhance real-world applicability, we offer two acceleration strategies: Pre-processing promptable embeddings and using linear approximations. We show that the former yields a 15% improvement in Recall@5 when prompts are predefined, while the latter achieves an 8% improvement when prompts are only available during inference.

cs.CV

Assessing and Mitigating Medical Knowledge Drift and Conflicts in Large Language Models

Large Language Models (LLMs) have great potential in the field of health care, yet they face great challenges in adapting to rapidly evolving medical knowledge. This can lead to outdated or contradictory treatment suggestions. This study investigated how LLMs respond to evolving clinical guidelines, focusing on concept drift and internal inconsistencies. We developed the DriftMedQA benchmark to simulate guideline evolution and assessed the temporal reliability of various LLMs. Our evaluation of seven state-of-the-art models across 4,290 scenarios demonstrated difficulties in rejecting outdated recommendations and frequently endorsing conflicting guidance. Additionally, we explored two mitigation strategies: Retrieval-Augmented Generation and preference fine-tuning via Direct Preference Optimization. While each method improved model performance, their combination led to the most consistent and reliable results. These findings underscore the need to improve LLM robustness to temporal shifts to ensure more dependable applications in clinical practice. The dataset is available at https://huggingface.co/datasets/RDBH/DriftMed.

cs.CL

Exploring How Generative MLLMs Perceive More Than CLIP with the Same Vision Encoder

Recent research has shown that CLIP models struggle with visual reasoning tasks that require grounding compositionality, understanding spatial relationships, or capturing fine-grained details. One natural hypothesis is that the CLIP vision encoder does not embed essential information for these tasks. However, we find that this is not always the case: The encoder gathers query-relevant visual information, while CLIP fails to extract it. In particular, we show that another branch of Vision-Language Models (VLMs), Generative Multimodal Large Language Models (MLLMs), achieve significantly higher accuracy than CLIP in many of these tasks using the same vision encoder and weights, indicating that these Generative MLLMs perceive more -- as they extract and utilize visual information more effectively. We conduct a series of controlled experiments and reveal that their success is attributed to multiple key design choices, including patch tokens, position embeddings, and prompt-based weighting. On the other hand, enhancing the training data alone or applying a stronger text encoder does not suffice to solve the task, and additional text tokens offer little benefit. Interestingly, we find that fine-grained visual reasoning is not exclusive to generative models trained by an autoregressive loss: When converted into CLIP-like encoders by contrastive finetuning, these MLLMs still outperform CLIP under the same cosine similarity-based evaluation protocol. Our study highlights the importance of VLM architectural choices and suggests directions for improving the performance of CLIP-like contrastive VLMs.

cs.LG

Learning Spatial-Preserving Hierarchical Representations for Digital Pathology

Whole slide images (WSIs) pose fundamental computational challenges due to their gigapixel resolution and the sparse distribution of informative regions. Existing approaches often treat image patches independently or reshape them in ways that distort spatial context, thereby obscuring the hierarchical pyramid representations intrinsic to WSIs. We introduce Sparse Pyramid Attention Networks (SPAN), a hierarchical framework that preserves spatial relationships while allocating computation to informative regions. SPAN constructs multi-scale representations directly from single-scale inputs, enabling precise hierarchical modeling of WSI data. We demonstrate SPAN's versatility through two variants: SPAN-MIL for slide classification and SPAN-UNet for segmentation. Comprehensive evaluations across multiple public datasets show that SPAN effectively captures hierarchical structure and contextual relationships. Our results provide clear evidence that architectural inductive biases and hierarchical representations enhance both slide-level and patch-level performance. By addressing key computational challenges in WSI analysis, SPAN provides an effective framework for computational pathology and demonstrates important design principles for large-scale medical image analysis.

cs.CV

What Makes for Robust Multi-Modal Models in the Face of Missing Modalities?

With the growing success of multi-modal learning, research on the robustness of multi-modal models, especially when facing situations with missing modalities, is receiving increased attention. Nevertheless, previous studies in this domain exhibit certain limitations, as they often lack theoretical insights or their methodologies are tied to specific network architectures or modalities. We model the scenarios of multi-modal models encountering missing modalities from an information-theoretic perspective and illustrate that the performance ceiling in such scenarios can be approached by efficiently utilizing the information inherent in non-missing modalities. In practice, there are two key aspects: (1) The encoder should be able to extract sufficiently good features from the non-missing modality; (2) The extracted features should be robust enough not to be influenced by noise during the fusion process across modalities. To this end, we introduce Uni-Modal Ensemble with Missing Modality Adaptation (UME-MMA). UME-MMA employs uni-modal pre-trained weights for the multi-modal model to enhance feature extraction and utilizes missing modality data augmentation techniques to better adapt to situations with missing modalities. Apart from that, UME-MMA, built on a late-fusion learning framework, allows for the plug-and-play use of various encoders, making it suitable for a wide range of modalities and enabling seamless integration of large-scale pre-trained encoders to further enhance performance. And we demonstrate UME-MMA's effectiveness in audio-visual datasets~(e.g., AV-MNIST, Kinetics-Sound, AVE) and vision-language datasets~(e.g., MM-IMDB, UPMC Food101).

cs.AI

Training-Free Robust Multimodal Learning via Sample-Wise Jacobian Regularization

Multimodal fusion emerges as an appealing technique to improve model performances on many tasks. Nevertheless, the robustness of such fusion methods is rarely involved in the present literature. In this paper, we propose a training-free robust late-fusion method by exploiting conditional independence assumption and Jacobian regularization. Our key is to minimize the Frobenius norm of a Jacobian matrix, where the resulting optimization problem is relaxed to a tractable Sylvester equation. Furthermore, we provide a theoretical error bound of our method and some insights about the function of the extra modality. Several numerical experiments on AV-MNIST, RAVDESS, and VGGsound demonstrate the efficacy of our method under both adversarial attacks and random corruptions.

cs.CV

Difference-in-Differences: Bridging Normalization and Disentanglement in PG-GAN

What mechanisms causes GAN's entanglement? Although developing disentangled GAN has attracted sufficient attention, it is unclear how entanglement is originated by GAN transformation. We in this research propose a difference-in-difference (DID) counterfactual framework to design experiments for analyzing the entanglement mechanism in on of the Progressive-growing GAN (PG-GAN). Our experiment clarify the mechanisms how pixel normalization causes PG-GAN entanglement during a input-unit-ablation transformation. We discover that pixel normalization causes object entanglement by in-painting the area occupied by ablated objects. We also discover the unit-object relation determines whether and how pixel normalization causes objects entanglement. Our DID framework theoretically guarantees that the mechanisms that we discover is solid, explainable and comprehensively.

cs.CV