arXiv subjects

Sjoerd B. Vos

Publications and source records attributed to Sjoerd B. Vos.

10 recordsLinked to original sources

arXiv2026

Mechanical behaviour of brain-skull interface (meninges) under shear loading through experiment and finite element modelling: Preliminary results

The brain-skull interface (meninges) plays a critical role in governing brain motion during head impacts, yet computational models often simplify this interface using idealized contact conditions due to limited experimental data. This study presents an improved protocol combining experimental testing and computational modelling to determine the mechanical properties of the brain-skull interface under shear loading. Brain tissue and brain-skull complex samples were extracted from sheep cadaver heads and subjected to shear loading. Magnetic resonance imaging (MRI) was used to obtain accurate 3D geometries of the samples, which were then used to create computational grids (meshes) for simulation of the experiments using finite element (FE) models to determine subject-specific properties of the brain tissue and brain-skull interface. A second-order Ogden hyperelastic model was used for the brain tissue, and a cohesive layer was employed to model the brain-skull interface. Our results indicate that a cohesive layer captures the force-displacement and damage initiation of the brain-skull interface. The calibrated cohesive properties showed consistent patterns across samples, with maximum normal tractions ranging from 2.8-3.4 kPa and maximum tangential tractions from 1.8-2.1 kPa. This framework provides a foundation for improving the biofidelity of computational head models used in injury prediction and neurosurgical planning by replacing arbitrary boundary conditions with formulations derived from experimental data on brain-skull interface (meninges) biomechanical behaviour.

cs.CE↗

arXiv2026

Quality assessment of brain structural MR images: Comparing generalization of deep learning versus hand-crafted feature-based machine learning methods to new sites

Quality assessment of brain structural MR images is critical for large-scale neuroimaging studies, where motion artifacts can significantly bias clinical estimates. While visual rating remains the gold standard, it is time-consuming and subjective. This study evaluates the relative performance and generalization capabilities of two prominent Automated Quality Assessment (AQA) methods: MRIQC, which uses hand-crafted image-quality metrics with traditional machine learning, and CNNQC, which utilizes a deep learning (DL) architecture. Using a heterogeneous dataset of 1,098 T1-weighted volumes from 17 different sites, we assessed performance on both seen sites and entirely new sites using a leave-one-site-out (LOSO) approach. Our results indicate that both DL and traditional ML methods struggle to generalize to new scanners or sites. While MRIQC generally achieved higher accuracy across most unseen sites, CNNQC demonstrated higher sensitivity for detecting poor-quality scans. Given that DL-based methods like CNNQC offer higher computational efficiency and do not require expensive pre-processing, they may be preferred for widespread deployment, provided that future work focuses on improving cross-site generalizability.

eess.IV↗

arXiv2026

Open diffusion MRI and connectivity data for epilepsy and surgery: The IDEAS II release

Epileptic seizures are generated in cerebral networks that propagate ictal and interictal activity. The structure of cerebral networks underpinning epileptic activity can be inferred from diffusion-weighted MRI (DWI). However, publicly available DWI data in individuals with epilepsy are scarce, and processing is technically challenging due to scan-specific artifacts, limiting research progress. Here, we release raw DWI data from 216 individuals with epilepsy and 98 healthy controls. Subject identifiers align with our previous data release (IDEAS), which includes T1-weighted and FLAIR MRI, surgical details, and long-term seizure outcomes after surgery. Preprocessing reduced distortions and artifacts, while fully processed data include diffusion metric maps in native and template space. We also provide parcellated structural connectomes using multiple atlases and connectivity measures. To illustrate the utility of this IDEAS II data, we replicated ENIGMA consortium findings, observing widespread reductions of fractional anisotropy, particularly ipsilateral to the area of seizure onset. We further demonstrate localised abnormality, and network connectivity using streamline tractography in a patient who subsequently underwent temporal lobe resection. This open dataset offers a comprehensive resource to advance research on structural connectivity and surgical outcomes in epilepsy.

q-bio.NC↗

arXiv2025

Combined impact of grey and superficial white matter abnormalities: implications for epilepsy surgery

Drug-resistant focal epilepsy is associated with abnormalities in the brain in both grey matter (GM) and superficial white matter (SWM). However, it is unknown if both types of abnormalities are important in supporting seizures. Here, we test if surgical removal of GM and/or SWM abnormalities relates to post-surgical seizure outcome in people with temporal lobe epilepsy (TLE). We analyzed structural imaging data from 143 TLE patients (pre-op dMRI and pre-op T1-weighted MRI) and 97 healthy controls. We calculated GM volume abnormalities and SWM mean diffusivity abnormalities and evaluated if their surgical removal distinguished seizure outcome groups post-surgically. At a group level, GM and SWM abnormalities were most common in the ipsilateral temporal lobe and hippocampus in people with TLE. Analyzing both modalities together, compared to in isolation, improved surgical outcome discrimination (GM AUC = 0.68, p < 0.01, WM AUC = 0.65, p < 0.01; Union AUC = 0.72, p < 0.01, Concordance AUC = 0.64, p = 0.04). Additionally, 100% of people who had all concordant abnormal regions resected had ILAE$_{1,2}$ outcomes. These findings suggest that regions identified as abnormal from both diffusion-weighted and T1-weighted MRIs are involved in the epileptogenic network and that resection of both types of abnormalities may enhance the chances of living without disabling seizures.

q-bio.NC↗

arXiv2024

The Imaging Database for Epilepsy And Surgery (IDEAS)

Magnetic resonance imaging (MRI) is a crucial tool to identify brain abnormalities in a wide range of neurological disorders. In focal epilepsy MRI is used to identify structural cerebral abnormalities. For covert lesions, machine learning and artificial intelligence algorithms may improve lesion detection if abnormalities are not evident on visual inspection. The success of this approach depends on the volume and quality of training data. Herein, we release an open-source dataset of preprocessed MRI scans from 442 individuals with drug-refractory focal epilepsy who had neurosurgical resections, and detailed demographic information. The MRI scan data includes the preoperative 3D T1 and where available 3D FLAIR, as well as a manually inspected complete surface reconstruction and volumetric parcellations. Demographic information includes age, sex, age of onset of epilepsy, location of surgery, histopathology of resected specimen, occurrence and frequency of focal seizures with and without impairment of awareness, focal to bilateral tonic-clonic seizures, number of anti-seizure medications (ASMs) at time of surgery, and a total of 1764 patient years of post-surgical follow up. Crucially, we also include resection masks delineated from post-surgical imaging. To demonstrate the veracity of our data, we successfully replicated previous studies showing long-term outcomes of seizure freedom in the range of around 50%. Our imaging data replicates findings of group level atrophy in patients compared to controls. Resection locations in the cohort were predominantly in the temporal and frontal lobes. We envisage our dataset, shared openly with the community, will catalyse the development and application of computational methods in clinical neurology.

q-bio.NC↗

arXiv2022

Intracranial EEG structure-function coupling predicts surgical outcomes in focal epilepsy

Alterations to structural and functional brain networks have been reported across many neurological conditions. However, the relationship between structure and function -- their coupling -- is relatively unexplored, particularly in the context of an intervention. Epilepsy surgery alters the brain structure and networks to control the functional abnormality of seizures. Given that surgery is a structural modification aiming to alter the function, we hypothesized that stronger structure-function coupling preoperatively is associated with a greater chance of post-operative seizure control. We constructed structural and functional brain networks in 39 subjects with medication-resistant focal epilepsy using data from intracranial EEG (pre-surgery), structural MRI (pre-and post-surgery), and diffusion MRI (pre-surgery). We investigated pre-operative structure-function coupling at two spatial scales a) at the global iEEG network level and b) at the resolution of individual iEEG electrode contacts using virtual surgeries. At global network level, seizure-free individuals had stronger structure-function coupling pre-operatively than those that were not seizure-free regardless of the choice of interictal segment or frequency band. At the resolution of individual iEEG contacts, the virtual surgery approach provided complementary information to localize epileptogenic tissues. In predicting seizure outcomes, structure-function coupling measures were more important than clinical attributes, and together they predicted seizure outcomes with an accuracy of 85% and sensitivity of 87%. The underlying assumption that the structural changes induced by surgery translate to the functional level to control seizures is valid when the structure-functional coupling is strong. Mapping the regions that contribute to structure-functional coupling using virtual surgeries may help aid surgical planning.

q-bio.NC↗

arXiv2022

Volumetric and structural connectivity abnormalities co-localise in TLE

Patients with temporal lobe epilepsy (TLE) exhibit both volumetric and structural connectivity abnormalities relative to healthy controls. How these abnormalities inter-relate and their mechanisms are unclear. We computed grey matter volumetric changes and white matter structural connectivity abnormalities in 144 patients with unilateral TLE and 96 healthy controls. Regional volumes were calculated using T1-weighted MRI, while structural connectivity was derived using white matter fibre tractography from diffusion-weighted MRI. For each regional volume and each connection strength, we calculated the effect size between patient and control groups in a group-level analysis. We then applied hierarchical regression to investigate the relationship between volumetric and structural connectivity abnormalities in individuals. Additionally, we quantified whether abnormalities co-localised within individual patients by computing Dice similarity scores. In TLE, white matter connectivity abnormalities were greater when joining two grey matter regions with abnormal volumes. Similarly, grey matter volumetric abnormalities were greater when joined by abnormal white matter connections. The extent of volumetric and connectivity abnormalities related to epilepsy duration, but co-localisation did not. Co-localisation was primarily driven by neighbouring abnormalities in the ipsilateral hemisphere. Overall, volumetric and structural connectivity abnormalities were related in TLE. Our results suggest that shared mechanisms may underlie changes in both volume and connectivity alterations in patients with TLE.

q-bio.NC↗

arXiv2020

Enhancing Fiber Orientation Distributions using convolutional Neural Networks

Accurate local fiber orientation distribution (FOD) modeling based on diffusion magnetic resonance imaging (dMRI) capable of resolving complex fiber configurations benefits from specific acquisition protocols that sample a high number of gradient directions (b-vecs), a high maximum b-value(b-vals), and multiple b-values (multi-shell). However, acquisition time is limited in a clinical setting and commercial scanners may not provide such dMRI sequences. Therefore, dMRI is often acquired as single-shell (single b-value). In this work, we learn improved FODs for commercially acquired MRI. We evaluate patch-based 3D convolutional neural networks (CNNs)on their ability to regress multi-shell FOD representations from single-shell representations, where the representation is a spherical harmonics obtained from constrained spherical deconvolution (CSD) to model FODs. We evaluate U-Net and HighResNet 3D CNN architectures on data from the Human Connectome Project and an in-house dataset. We evaluate how well each CNN model can resolve local fiber orientation 1) when training and testing on datasets with the same dMRI acquisition protocol; 2) when testing on a dataset with a different dMRI acquisition protocol than used to train the CNN models; and 3) when testing on a dataset with a fewer number of gradient directions than used to train the CNN models. Our approach may enable robust CSD model estimation on single-shell dMRI acquisition protocols with few gradient directions, reducing acquisition times, facilitating translation of improved FOD estimation to time-limited clinical environments.

eess.IV↗

arXiv2020

Focal to bilateral tonic-clonic seizures are associated with widespread network abnormality in temporal lobe epilepsy

Objective: To identify if whole-brain structural network alterations in patients with temporal lobe epilepsy (TLE) and focal to bilateral tonic-clonic seizures (FBTCS) differ from alterations in patients without FBTCS. Methods: We dichotomized a cohort of 83 drug-resistant patients with TLE into those with and without FBTCS and compared each group to 29 healthy controls. For each subject, we used diffusion MRI to construct whole-brain structural networks. First, we measured the extent of alterations by performing FBTCS-negative (FBTCS-) versus control and FBTCS-positive (FBTCS+) versus control comparisons, thereby delineating altered sub-networks of the whole-brain structural network. Second, by standardising networks of each patient using control networks, we measured the subject-specific abnormality at every brain region in the network, thereby quantifying the spatial localisation and the amount of abnormality in every patient. Results: Both FBTCS+ and FBTCS- patient groups had altered sub-networks with reduced fractional anisotropy (FA) and increased mean diffusivity (MD) compared to controls. The altered subnetwork in FBTCS+ patients was more widespread than in FBTCS- patients (441 connections altered at t>3, p<0.001 in FBTCS+ compared to 21 connections altered at t>3, p=0.01 in FBTCS-). Significantly greater abnormalities-aggregated over the entire brain network as well as assessed at the resolution of individual brain areas-were present in FBTCS+ patients (p<0.001, d=0.82). In contrast, the fewer abnormalities present in FBTCS- patients were mainly localised to the temporal and frontal areas. Significance: The whole-brain structural network is altered to a greater and more widespread extent in patients with TLE and FBTCS. We suggest that these abnormal networks may serve as an underlying structural basis or consequence of the greater seizure spread observed in FBTCS.

q-bio.NC↗

arXiv2020

Multivariate white matter alterations are associated with epilepsy duration

Previous studies investigating associations between white matter alterations and duration of temporal lobe epilepsy (TLE) have shown differing results, and were typically limited to univariate analyses of tracts in isolation. In this study we apply a multivariate measure (the Mahalanobis distance), to capture the distinct ways white matter may differ in individual patients, and relate this to epilepsy duration. Diffusion MRI, from a cohort of 94 subjects (28 healthy controls, 33 left-TLE and 33 right-TLE), was used to assess associations between tract fractional anisotropy (FA) and epilepsy duration. Using ten white matter tracts, we analysed associations using traditional univariate analyses (z-scores) and a complementary multivariate approach (Mahalanobis distance), incorporating multiple white matter tracts into a single unified analysis. In patients with right-TLE, FA was not significantly associated with epilepsy duration for any tract studied in isolation. In patients with left-TLE, the FA of two limbic tracts (ipsilateral fornix, contralateral cingulum gyrus) was significantly negatively associated with epilepsy duration (Bonferonni corrected p<0.05). Using a multivariate approach we found significant ipsilateral positive associations with duration in both left, and right-TLE cohorts (left-TLE: Spearman's rho=0.487, right-TLE: Spearman's rho=0.422). Extrapolating our multivariate results to duration equals zero (i.e. at onset) we found no significant difference between patients and controls. Associations using the multivariate approach were more robust than univariate methods. The multivariate distance measure provides non-overlapping and more robust results than traditional univariate analyses. Future studies should consider adopting both frameworks into their analysis in order to ascertain a more complete understanding of epilepsy progression, regardless of laterality.

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